Treatment of experimental human breast cancer and lung cancer brain metastases in mice by macitentan, a dual antagonist of endothelin receptors, combined with paclitaxel

Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice

(2015) S.-J. Kim et al.   CLINICAL CANCER RESEARCH

Astrocytes Upregulate Survival Genes in Tumor Cells and Induce Protection from Chemotherapy

(2015) Sun-Jin Kim et al.   NEOPLASIA

Macitentan: A Review of Its Use in Patients with Pulmonary Arterial Hypertension

(2014) Sohita Dhillon   DRUGS

Current approaches to the treatment of metastatic brain tumours

(2014) Taofeek K. Owonikoko et al.   Nature Reviews Clinical Oncology

A Randomized Trial of Bevacizumab for Newly Diagnosed Glioblastoma

(2014) Mark R. Gilbert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Roles for Endothelin Receptor B and BCL2A1 in Spontaneous CNS Metastasis of Melanoma

(2012) W. Cruz-Munoz et al.   CANCER RESEARCH

FOXO1 Mediates the Autocrine Effect of Endothelin-1 on Endothelial Cell Survival

(2012) Vincenza Cifarelli et al.   MOLECULAR ENDOCRINOLOGY

Therapy-resistant tumor microvascular endothelial cells contribute to treatment failure in glioblastoma multiforme

(2012) T Borovski et al.   ONCOGENE

Perceptions and Experiences of Research Participants on Gender-Based Violence Community Based Survey: Implications for Ethical Guidelines

(2012) Yandisa Sikweyiya et al.   PLoS One

The Vascular Endothelial Growth Factor Receptor Inhibitor Sunitinib Causes a Preeclampsia-Like Syndrome With Activation of the Endothelin System

(2011) Mariëtte H.W. Kappers et al.   HYPERTENSION

Sunitinib-Induced Systemic Vasoconstriction in Swine Is Endothelin Mediated and Does Not Involve Nitric Oxide or Oxidative Stress

(2011) Mariëtte H.W. Kappers et al.   HYPERTENSION

Autocrine Endothelin-3/Endothelin Receptor B Signaling Maintains Cellular and Molecular Properties of Glioblastoma Stem Cells

(2011) Y. Liu et al.   MOLECULAR CANCER RESEARCH

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice

(2011) J. F. de Groot et al.   NEURO-ONCOLOGY

Capturing Changes in the Brain Microenvironment during Initial Steps of Breast Cancer Brain Metastasis

(2010) Mihaela Lorger et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterogeneous Blood-Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer

(2010) P. R. Lockman et al.   CLINICAL CANCER RESEARCH

Preclinical approaches to study the biology and treatment of brain metastases

(2010) William Cruz-Muñoz et al.   SEMINARS IN CANCER BIOLOGY

Hypertension Induced by Vascular Endothelial Growth Factor Signaling Pathway Inhibition: Mechanisms and Potential Use as a Biomarker

(2010) Emily S. Robinson et al.   SEMINARS IN NEPHROLOGY

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

The Vascular Basement Membrane as “Soil” in Brain Metastasis

(2009) W. Shawn Carbonell et al.   PLoS One

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

(2008) M. Iglarz et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phase I safety study of escalating doses of atrasentan in adults with recurrent malignant glioma

(2008) Surasak Phuphanich et al.   NEURO-ONCOLOGY