Article
Endocrinology & Metabolism
Marc Leal-Julia, Jorge J. Vilches, Andrea Onieva, Sergi Verdes, Angela Sanchez, Miguel Chillon, Xavier Navarro, Assumpcio Bosch
Summary: This study characterized the proteome of neural tissues in a type 2 diabetes mouse model and identified differential protein expression profiles related to reduced glycolytic and TCA cycle metabolism, increased lipid catabolism, dysregulation of muscle-like proteins, altered cytoskeleton-related proteins, activation of inflammatory responses, and changes in glutathione metabolism and oxidative stress. These findings suggest that energy deficiency may play a key role in the neurodegeneration observed in diabetic neuropathy.
MOLECULAR METABOLISM
(2022)
Article
Neurosciences
Hong-Jun Cao, Li Huang, Meng-Ru Zheng, Tao Zhang, Ling-Chi Xu
Summary: This study comprehensively investigates the expression of circular RNAs in rat DRGs following injuries to the central and peripheral axon branches and identifies a total of 33 differentially expressed circular RNAs after central branch injury and 55 differentially expressed circular RNAs after peripheral branch injury. The functional enrichment analysis of host genes of differentially expressed circular RNAs reveals the involvement of the Hippo signaling pathway and Notch signaling pathway after both central and peripheral axon injuries.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Anna Starinets, Anna Tyrtyshnaia, Igor Manzhulo
Summary: The study finds that synaptamide can alleviate neuropathic pain in the peripheral nervous system, promote remyelination, and have anti-inflammatory effects. This highlights the potential of synaptamide for neuropathic pain management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Marie C. Walters, David R. Ladle
Summary: The study reveals that there is an abnormality in calcium homeostasis in proprioceptive neurons after peripheral nerve injury, potentially contributing to the failure to fully recover proprioceptive reflexes. Significant differences in calcium transients between crush and transection animals post-reinnervation suggest that alterations in calcium homeostasis are specific to injury type.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junjie Zhang, Chunyi Jiang, Xiaohong Liu, Chen-Xiao Jiang, Qianqian Cao, Bin Yu, Yaohui Ni, Susu Mao
Summary: Identifying novel molecules involved in axon regeneration in the peripheral nervous system (PNS) can help in developing therapeutic strategies for repairing axon damage in both PNS and CNS. Metabolism and axon regeneration are closely linked, with several metabolic pathways being significantly altered during the process. N, N-dimethylglycine (DMG) was found to have a promoting effect on regenerative ability post injury, suggesting it as a potential candidate drug for nerve repair.
Article
Cell Biology
Yin-Ying Shen, Rui-Rui Zhang, Qian-Yan Liu, Shi-Ying Li, Sheng Yi
Summary: Cellular senescence and proliferation are essential for wound healing and tissue remodeling. This study analyzed gene expression patterns in rat sciatic nerve stumps and dorsal root ganglia after injury to reveal the genetic changes associated with cellular senescence and proliferation. The study found that cellular senescence and proliferation were less vigorous in the dorsal root ganglia compared to the sciatic nerve stumps.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemical Research Methods
Andres Di Paolo, Joaquina Farias, Joaquin Garat, Andrew Macklin, Vladimir Ignatchenko, Thomas Kislinger, Jose Sotelo Silveira
Summary: In this study, proteomic analysis was used to investigate axons in adult rat sciatic nerves, revealing an increase in ribosomal proteins after injury and newly synthesized axonal proteins. The results suggest that proteomics profiling is an effective method for interrogating axons, and that ribosomal proteins may play an important role during injury.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Hannes Schmidt, Alexandra Bottcher, Tilman Gross, Achim Schmidtko
Summary: The cGMP signalling pathways play crucial roles in the somatosensory system, regulating physiological processes from embryonic development to adulthood. During embryonic development, a cGMP-dependent signalling cascade is essential for axon bifurcation, while in adulthood, various cGMP signalling pathways in different cell populations are involved in pain and itch processing.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Cell Biology
Mary L. Tapia, Gabriel Nascimento-dos-Santos, Kevin K. Park
Summary: This review discusses the heterogeneity of retinal ganglion cells (RGCs) and their differential resilience to injury and regeneration. By identifying molecular features and studying different regeneration models, specific RGC types that exhibit preferential survival and regeneration have been discovered. Cellular characteristics and the selective expression of certain genes may contribute to their reparative capacity. These studies lay an important groundwork for identifying factors that promote neural regeneration and developing targeted therapy for RGC degeneration and neurodegenerative diseases in general.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Farhana Naznin, T. M. Zaved Waise, Paul Fernyhough
Summary: Impairments in mitochondrial physiology, specifically the muscarinic acetylcholine type 1 receptor (M1R) pathway, play a role in the progression of neurodegenerative conditions such as peripheral neuropathy in diabetes. Inhibition of M1R using specific antagonists can prevent mitochondrial dysfunction and nerve degeneration. Activation of AMPK through pirenzepine and muscarinic toxin 7 (MT7) can improve sensory abnormalities and nerve fiber loss. The negative regulation of the M1R-dependent pathway could be a potential therapeutic target for enhancing mitochondrial function and repairing nerve damage.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Article
Neurosciences
Kai Zhang, Qingyao Wang, Yiyao Liang, Yu Yan, Haiqiong Wang, Xu Cao, Bing Shan, Yaoyang Zhang, Ang Li, Yanshan Fang
Summary: Nerve injury leads to changes in protein levels, with ADPGK significantly increased in the injured nerve. Upregulated ADPGK in macrophages post-injury promotes phagocytosis, suggesting a role in injury-induced inflammatory responses. This study provides insights into the molecular mechanisms underlying neural injury and inflammation.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Jia-wen Xu, Xu Xu, Yun Ling, Yan-chun Wang, Yu-jie Huang, Juan-zhen Yang, Jia-ying Wang, Xu Shen
Summary: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes without cure. In this study, the therapeutic potential of vincamine (Vin), a GPR40 agonist, in ameliorating DPN-like pathology was evaluated in diabetic mice. The results showed that Vin administration improved neurological dysfunctions, blood flow velocities, blood perfusion areas, myelin sheath injury, and intraepidermal nerve fiber density impairment in DPN mice, suggesting that pharmacological activation of GPR40 could be a promising therapeutic strategy for DPN.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Developmental Biology
Patricia J. Ward, Rachel A. Davey, Jeffrey D. Zajac, Arthur W. English
Summary: Neuronal activity after nerve injury enhances axon regeneration and function restoration, with a key role played by androgen receptor signaling, both neuronal and involving classical genomic pathways. The requirement of genomic neuronal androgen receptor signaling for activity-dependent axon regeneration is essential in both sexes according to the results.
DEVELOPMENTAL NEUROBIOLOGY
(2021)
Review
Cell Biology
Aidan McGinnis, Ru-Rong Ji
Summary: Preclinical studies have found that glial cells play a crucial role in the development and maintenance of neuropathic pain in conditions such as diabetes, chemotherapy, major surgeries, and virus infections. Satellite glial cells (SGCs) in the peripheral nervous system (PNS) and astrocytes in the central nervous system (CNS) exhibit similar characteristics and functions in the genesis of neuropathic pain. However, SGCs are not simply peripheral astrocytes and have unique roles and interactions. Recent findings also suggest that SGCs are enriched with proteins related to fatty acid metabolism, which may have implications for novel therapeutic approaches targeting glial cells.
Article
Cell Biology
Christopher T. Rhodes, Giulia Zunino, Shu-Wei Angela Huang, Sandra M. Cardona, Astrid E. Cardona, Mitchel S. Berger, Vance P. Lemmon, Chin-Hsing Annie Lin
Article
Medicine, Research & Experimental
Nathan P. Coussens, G. Sitta Sittampalam, Rajarshi Guha, Kyle Brimacombe, Abigail Grossman, Thomas D. Y. Chung, Jeffrey R. Weidner, Terry Riss, O. Joseph Trask, Douglas Auld, Jayme L. Dahlin, Viswanath Devanaryan, Timothy L. Foley, James Mcgee, Steven D. Kahl, Stephen C. Kales, Michelle Arkin, Jonathan Baell, Bruce Bejcek, Neely Gal-Edd, Marcie Glicksman, Joseph V. Haas, Philip W. Iversen, Marilu Hoeppner, Stacy Lathrop, Eric Sayers, Hanguan Liu, Bart Trawick, Julie Mcvey, Vance P. Lemmon, Zhuyin Li, Owen McManus, Lisa Minor, Andrew Napper, Mary Jo Wildey, Robert Pacifici, William W. Chin, Menghang Xia, Xin Xu, Madhu Lal-Nag, Matthew D. Hall, Sam Michael, James Inglese, Anton Simeonov, Christopher P. Austin
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2018)
Article
Neurosciences
Amber R. Hackett, Stephanie L. Yahn, Kirill Lyapichev, Angela Dajnoki, Do-Hun Lee, Mario Rodriguez, Natasha Cammer, Ji Pak, Saloni T. Mehta, Olaf Bodamer, Vance P. Lemmon, Jae K. Lee
EXPERIMENTAL NEUROLOGY
(2018)
Article
Cell Biology
Arnau Hervera, Francesco De Virgiliis, Ilaria Palmisano, Luming Zhou, Elena Tantardini, Guiping Kong, Thomas Hutson, Matt C. Danzi, Rotem Ben-Tov Perry, Celio X. C. Santos, Alexander N. Kapustin, Roland A. Fleck, Jose Antonio Del Rio, Thomas Carroll, Vance Lemmon, John L. Bixby, Ajay M. Shah, Mike Fainzilber, Simone Di Giovanni
NATURE CELL BIOLOGY
(2018)
Article
Neurosciences
Matt C. Danzi, Saloni T. Mehta, Kireeti Dulla, Giulia Zunino, Daniel J. Cooper, John L. Bixby, Vance P. Lemmon
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Article
Chemistry, Medicinal
Hassan Al-Ali, Ginamarie Debevec, Radleigh G. Santos, Richard A. Houghten, Jennifer C. Davis, Adel Nefzi, Vance P. Lemmon, John L. Bixby, Marc A. Giulianotti
ACS MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Neurosciences
Martin Oudega, Peng Hao, Junkui Shang, Agnes E. Haggerty, Zijue Wang, Jian Sun, Daniel J. Liebl, Yan Shi, Liming Cheng, Hongmei Duan, Yi Eve Sun, Xiaoguang Li, Vance P. Lemmon
EXPERIMENTAL NEUROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Arnau Hervera, Luming Zhou, Ilaria Palmisano, Eilidh McLachlan, Guiping Kong, Thomas H. Hutson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Andreu Matamoros-Angles, Kirsi Forsberg, Francesco De Virgiliis, Dina P. Matheos, Janine Kwapis, Marcelo A. Wood, Radhika Puttagunta, Jose Antonio del Rio, Simone Di Giovanni
Article
Cell Biology
Thomas H. Hutson, Claudia Kathe, Ilaria Palmisano, Kay Bartholdi, Arnau Hervera, Francesco De Virgiliis, Eilidh Mclachlan, Luming Zhou, Guiping Kong, Quentin Barraud, Matt C. Danzi, Alejandro Medrano-Fernandez, Jose P. Lopez-Atalaya, Anne L. Boutillier, Sarmistha H. Sinha, Akash K. Singh, Piyush Chaturbedy, Lawrence D. F. Moon, Tapas K. Kundu, John L. Bixby, Vance P. Lemmon, Angel Barco, Gregoire Courtine, Simone Di Giovanni
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Biochemical Research Methods
Prajwal Devkota, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Stefan Wuchty
Article
Neurosciences
Vance P. Lemmon
Summary: Published in 1981, a study on the receptive field properties of neurons in the reeler mouse visual cortex revealed robust systems ensuring proper formation of connections in mouse cortex. This study transformed the author from an electrophysiologist into a molecular neuroscientist studying cell adhesion molecules and axon growth regulation mechanisms. It highlights the importance of collaboration and available technologies in driving scientific discoveries.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Francesco De Virgiliis, Thomas H. Hutson, Ilaria Palmisano, Sarah Amachree, Jian Miao, Luming Zhou, Rositsa Todorova, Richard Thompson, Matt C. Danzi, Vance P. Lemmon, John L. Bixby, Ilka Wittig, Ajay M. Shah, Simone Di Giovanni
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Jeffrey A. Lowell, Nicholas O'Neill, Matt C. Danzi, Hassan Al-Ali, John L. Bixby, Vance P. Lemmon
Summary: This study identified novel transcriptional regulators of neurite outgrowth downstream of the kinase inhibitor RO48, with the Fox family transcription factor Foxp2 restricting neurite outgrowth and the FoxO subfamily members Foxo1 and Foxo3a promoting neurite outgrowth. The transcriptomic-phenotypic screening strategy utilized in this study allowed for the discovery of these new regulators associated with axon growth.
Article
Immunology
Jeffrey A. Lowell, Emre Dikici, Pratibha M. Joshi, Ralf Landgraf, Vance P. Lemmon, Sylvia Daunert, Sari Izenwasser, Pirouz Daftarian
Article
Neurosciences
Eric R. Bray, Markus Noga, Kinjal Thakor, Yunfang Wang, Vance P. Lemmon, Kevin K. Park, Pantelis Tsoulfas