Review
Nutrition & Dietetics
Nicoline H. J. Leenders, Emma A. Vermeulen, Adriana J. van Ballegooijen, Tiny Hoekstra, Ralph de Vries, Joline W. Beulens, Marc G. Vervloet
Summary: This study aimed to evaluate the association of plasma magnesium concentration with clinically relevant outcomes in chronic kidney disease patients. The results showed that higher magnesium levels were associated with a lower risk of all-cause mortality, cardiovascular mortality, and events.
CLINICAL NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Jialing Zhang, Qi Pang, Shiyuan Wang, Leiyun Wu, Aihua Zhang
Summary: This meta-analysis found that cardiac valve calcification (CVC) is associated with mortality in chronic kidney disease (CKD) patients. CVC is related to factors such as age, body mass index, left atrial dimension, C-reactive protein level, and ejection fraction, as well as calcium and phosphate metabolism dysfunction, diabetes, coronary heart disease, and duration of dialysis. However, the prognostic value of CVC for mortality is no longer significant in patients undergoing peritoneal dialysis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Mehmet Kanbay, Sidar Copur, Dimitrie Siriopol, Abdullah B. Yildiz, Metehan Berkkan, Kathherine R. Tuttle, Carmine Zoccali
Summary: Metabolically healthy overweight and obese individuals have a higher risk of chronic kidney disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Peripheral Vascular Disease
Guido Grassi, Annalisa Biffi, Gino Seravalle, Silvio Bertoli, Flavio Airoldi, Giovanni Corrao, Anna Pisano, Francesca Mallamaci, Giuseppe Mancia, Carmine Zoccali
Summary: This meta-analysis found that the sympathetic nervous system is significantly overactive in CKD patients compared to healthy individuals, with a direct relationship between MSNA and renal function, age, BMI, and heart rate. As CKD progresses, sympathetic activation intensifies and correlates with heart rate, but not with plasma norepinephrine levels.
JOURNAL OF HYPERTENSION
(2021)
Review
Nutrition & Dietetics
Maribel Luceron-Lucas-Torres, Alicia Saz-Lara, Ana Diez-Fernandez, Irene Martinez-Garcia, Vicente Martinez-Vizcaino, Ivan Cavero-Redondo, Celia Alvarez-Bueno
Summary: The objective of this systematic review and meta-analysis was to examine the association between wine consumption and cardiovascular mortality, CVD, and CHD, and analyze the influence of personal and study factors. A total of 25 studies were included in the review, and the meta-analysis showed that wine consumption was inversely associated with the risk of CHD (RR=0.76), CVD (RR=0.83) and cardiovascular mortality (RR=0.73). Age, female proportion, and follow-up time did not affect this association. However, caution is needed when interpreting these findings as increasing wine intake may be harmful to certain individuals.
Review
Endocrinology & Metabolism
Amir Hossein Behnoush, Parnian Shobeiri, Pegah Bahiraie, Nikan Amirkhani, Amirmohammad Khalaji, Soheil Peiman
Summary: This systematic review and meta-analysis found that chemerin levels were significantly higher in patients with chronic kidney disease (CKD) compared to healthy controls. These findings suggest that chemerin may serve as a biomarker in CKD patients and provide insights into the pathophysiology of the disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Susanna C. Larsson, Stephen Burgess
Summary: This study summarized evidence from Mendelian randomization studies, confirming a causal relationship between excess adiposity and a variety of chronic diseases. Genetically predicted higher BMI was associated with increased risk for several chronic diseases, while higher adult BMI was associated with decreased risk for certain diseases.
Review
Medicine, General & Internal
Zhongwei Zhou, Hao Jin, Huixiang Ju, Mingzhong Sun, Hongmei Chen, Li Li
Summary: This meta-analysis found that higher circulating TMAO levels were associated with increased all-cause and cardiovascular mortality risks among patients with chronic kidney disease (CKD). The relationship may be dependent on the dose of TMAO and independent of renal function, inflammation, diabetes, hypertension, and dyslipidemia.
FRONTIERS IN MEDICINE
(2022)
Review
Urology & Nephrology
Yanshan Lin, Chunqun Li, David Waters, Chun Shing Kwok
Summary: Gastrointestinal bleeding (GIB) affects 2% of patients with chronic kidney disease (CKD) and the rate is higher among those undergoing endoscopy. Receipt of dialysis, older age, diabetes mellitus, history of ulcers, and cirrhosis are significantly associated with GIB. GIB is also associated with a twofold increase in the odds of mortality.
Review
Endocrinology & Metabolism
Lihong Chen, Shiyi Sun, Yunyi Gao, Xingwu Ran
Summary: This meta-analysis reveals that patients with diabetic foot ulcers have a high overall mortality, with nearly 50% mortality within 5 years. Cardiovascular disease and infection are the leading causes of death.
DIABETES OBESITY & METABOLISM
(2023)
Review
Medicine, General & Internal
Yachun Li, Hongmei Lu, Jing Guo, Meiling Zhang, Huijuan Zheng, Yuning Liu, Weijing Liu
Summary: This study aims to assess the correlation between circulating trimethylamine N-oxide (TMAO) concentration and the risk of all-cause and cardiovascular death in chronic kidney disease (CKD) patients. The results show that CKD patients with higher TMAO concentrations have an increased risk of all-cause mortality. Moreover, elevated TMAO levels raise the cardiovascular mortality risk in certain CKD patients. TMAO concentrations are strongly correlated with glomerular filtration rate (GFR) and inflammation in non-dialysis CKD patients.
ANNALS OF MEDICINE
(2023)
Review
Medicine, General & Internal
Jia Li, Dongwei Liu, Zhangsuo Liu
Summary: The study found that elevated serum total bilirubin levels within the physiological range are associated with a lower risk of chronic kidney disease and show a linear dose-response relationship, but whether high STB levels are a protective factor against mortality remains inconclusive.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Josefin Soppert, Janina Frisch, Julia Wirth, Christian Hemmers, Peter Boor, Rafael Kramann, Sonja Vondenhoff, Julia Moellmann, Michael Lehrke, Mathias Hohl, Emiel P. C. van der Vorst, Christian Werner, Thimoteus Speer, Christoph Maack, Nikolaus Marx, Joachim Jankowski, Leticia Prates Roma, Heidi Noels
Summary: Chronic kidney disease (CKD) increases the risk of developing uremic cardiomyopathy, and animal studies are used to investigate the underlying mechanisms. This review systematically analyzed 88 studies and performed meta-analyses of 52 to identify suitable animal models for future experimental studies. The results showed variations in different mouse strains and the effects of CKD on cardiac hypertrophy, fibrosis, and function. Multifactorial hit models consistently induced cardiac hypertrophy and fibrosis compared to single hit kidney injury models.
KIDNEY INTERNATIONAL
(2022)
Review
Food Science & Technology
Angelica Kuria, Hongdou Tian, Mei Li, Yinhe Wang, Jan Olav Aaseth, Jiajie Zang, Yang Cao
Summary: High selenium levels in the body are associated with decreased risk of CVD incidence and mortality. There is a 15% reduction in CVD risk for every 10 μg increase in blood selenium concentration. However, caution should be exercised regarding potential harmful effects of excessive selenium intake.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Review
Peripheral Vascular Disease
Takashin Nakayama, Ryunosuke Mitsuno, Tatsuhiko Azegami, Yasunori Sato, Kaori Hayashi, Hiroshi Itoh
Summary: Although discontinuing renin-angiotensin system (RAS) inhibitors in chronic kidney disease (CKD) patients is common due to adverse events, this study's meta-analysis showed that discontinuation of RAS inhibitors is associated with an increased risk of all-cause mortality, end-stage kidney disease (ESKD), and major adverse cardiovascular events (MACE), but not hyperkalemia. The overall risk of bias was moderate-to-serious, and the quality of evidence was low-to-very low. Thus, continuing RAS inhibitors may benefit CKD patients.
HYPERTENSION RESEARCH
(2023)
Article
Medicine, General & Internal
Sankar D. Navaneethan, Sophia Zoungas, M. Luiza Caramori, Juliana C. N. Chan, Hiddo J. L. Heerspink, Clint Hurst, Adrian Liew, Erin D. Michos, Wasiu A. Olowu, Tami Sadusky, Nikhil Tandon, Katherine R. Tuttle, Christoph Wanner, Katy G. Wilkens, Jonathan C. Craig, David J. Tunnicliffe, Marcello Tonelli, Michael Cheung, Amy Earley, Peter Rossing, Ian H. de Boer, Kamlesh Khunti
Summary: The KDIGO 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease is an update of the 2020 guideline. The guideline was updated based on reviewing new evidence and using the GRADE approach to assess evidence and develop consensus practice points. The recommendations were updated in the areas of comprehensive care and glucose-lowering therapies, while recommendations in the areas of glycemic monitoring, lifestyle interventions, and management approaches remained unchanged.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Ethics
Alison C. Weightman, Simon Coghlan, Philip A. Clayton
Summary: The refusal of doctors to accept donations from living kidney donors with certain comorbidities is unjustified according to this paper. The paper argues for greater acceptance of such donations to address the ongoing shortage of kidney transplants.
MONASH BIOETHICS REVIEW
(2023)
Article
Urology & Nephrology
Joe Lu, Erandi Hewawasam, Christopher E. Davies, Philip A. Clayton, Stephen P. McDonald, Shilpanjali Jesudason
Summary: This study aimed to determine the rates of preeclampsia in women with kidney transplants and its association with graft survival and function. The results showed that while preeclampsia is common in women with transplanted kidneys, it is not associated with worse graft survival or function.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Endocrinology & Metabolism
Alison Hayes, Rakhee Raghunandan, Anagha Killedar, Sarah Smith, Erin Cvejic, Martin Howell, Stavros Petrou, Emily Lancsar, Germaine Wong, Jonathan Craig, Kirsten Howard
Summary: This study aimed to assess the reliability, acceptability, validity, and responsiveness of the PedsQL and the CHU9D in measuring health-related quality of life (HRQoL) among children and adolescents with overweight and obesity. The results showed that both instruments demonstrated good internal consistency reliability and high acceptability. However, PedsQL showed better known groups validity and responsiveness compared to CHU9D. In conclusion, PedsQL and CHU9D have good psychometric properties in measuring HRQoL in pediatric overweight and obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Urology & Nephrology
Emma O'Lone, Fred S. Apple, James O. Burton, Fergus J. Caskey, Jonathan C. Craig, Christopher R. deFilippi, Derek Forfang, Karen A. Hicks, Vivekanand Jha, Kenneth W. Mahaffey, Patrick B. Mark, Patrick Rossignol, Nicole Scholes-Robertson, Allison Jaue, Andrea K. Viecelli, Angela Y. Wang, David C. Wheele, David White, Wolfgang C. Winkelmayer, Charles A. Herzog
Summary: Cardiovascular disease is the leading cause of death in hemodialysis patients. However, there is currently no standardized definition of myocardial infarction (MI) for this population. The international working group recommends specific approaches for interpreting ischemic symptoms and performing baseline electrocardiograms to improve the accuracy of MI diagnosis in hemodialysis patients. While baseline cardiac troponin values are not recommended, serial cardiac biomarkers should be obtained when ischemia is suspected.
KIDNEY INTERNATIONAL
(2023)
Editorial Material
Urology & Nephrology
Bruno Ranchin, Claus Peter Schmitt, Bradley Warady, Jonathan C. Craig, Christoph Licht, Hiroshi Hataya, Enrico Vidal, Johan Vande Walle, Rukshana Shroff
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Nicole Scholes-Robertson, Katrina Blazek, Allison Tong, Talia Gutman, Jonathan C. Craig, Beverley M. Essue, Kirsten Howard, Germaine Wong, Martin Howell
Summary: This study aims to quantify the financial impact and out-of-pocket expenditure of rural adult patients with chronic kidney disease (CKD) in Australia. The survey results showed that the mean out-of-pocket expenses were 5056 AUD annually, and 78% of households experienced financial hardship, with 54% classified as experiencing financial catastrophe. Additionally, some participants had to relocate for a period greater than 3 months to access care, raising concerns about equity in Australia.
Article
Medicine, General & Internal
Andrea Matus Gonzalez, Eduardo Lorca, Sebastian Cabrera, Alejandra Hernandez, Carlos Zuniga-SM, Laura Sola, Luis Michea, Alejandro Ferreiro Fuentes, Lilia Cervantes, Magdalena Madero, Armando Teixeira-Pinto, Germaine Wong, Jonathan Craig, Allison Jaure
Summary: Nephrologists in Latin America faced personal and professional vulnerability while caring for patients undergoing regular hemodialysis during the COVID-19 pandemic. They reported feeling helpless and morally distressed, doubting their ability to provide safe care. Better availability and adaptation of care models, including telehealth and home-based dialysis, are urgently needed.
Meeting Abstract
Pediatrics
Campbell Drohan, Siah Kim, Anita Van Zwieten, Rabia Khalid, Anne Durkan, Deirdre Hahn, Suncica Lah, Anna Francis, Steve McTaggert, Amanda Walker, Fiona Mackie, Chanel Prestidge, Allison Tong, Jonathan C. Craig, Germaine Wong
PEDIATRIC NEPHROLOGY
(2023)
Meeting Abstract
Pediatrics
Adam Hudson, Siah Kim, Anita Van Zwiten, Rhabia Khalid, Anne Durkan, Deirdre Hahn, Chandana Guha, Anna Francis, Steven McTaggart, Amanda Walker, Fiona Mackie, Chanel Prestidge, Allison Tong, Jonathan C. Craig, Germaine Wong
PEDIATRIC NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Edmund Y. M. Chung, Suetonia C. Palmer, Valeria M. Saglimbene, Jonathan C. Craig, Marcello Tonelli, Giovanni F. M. Strippoli
Summary: This update of the Cochrane review found that erythropoiesis-stimulating agents (ESAs) may be more effective than placebo in treating anaemia in patients with chronic kidney disease, but their use may also increase the risk of cardiovascular events and hypertension. The comparative effects of different ESAs and their effects on other outcomes such as cardiovascular death and kidney failure remain uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Medicine, General & Internal
Deirdre Hahn, Elisabeth M. Hodson, Jonathan C. Craig
Summary: This article is a review study on IgA vasculitis. The study found that the use of corticosteroids or antiplatelet agents may have little or no benefit in preventing kidney disease in children with IgAV. MMF or tacrolimus may be less effective in treating severe IgAV-associated kidney disease compared to IV cyclophosphamide, but with fewer adverse effects. The efficacy of cyclosporin, MMF, or leflunomide in the treatment of severe IgAV-associated kidney disease in children remains unclear.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)
Review
Economics
Tessa Peasgood, Martin Howell, Rakhee Raghunandan, Amber Salisbury, Marcus Sellars, Gang Chen, Joanna Coast, Jonathan C. Craig, Nancy J. Devlin, Kirsten Howard, Emily Lancsar, Stavros Petrou, Julie Ratcliffe, Rosalie Viney, Germaine Wong, Richard Norman, Cam Donaldson
Summary: This study aimed to synthesize knowledge on the social value of child and adult health and found that the majority of studies supported prioritizing children. However, not all studies were consistent with this view, and there are research gaps in understanding the value of health gains for very young children and the motivations behind the public's views.
Meeting Abstract
Urology & Nephrology
Siah Kim, Anita Van Zwieten, Chandana Guha, Rabia Khalid, Madeleine Didsbury, Anna Francis, Steven Mctaggart, Fiona Mackie, Chanel Prestidge, Armando Teixeira-Pinto, Kirsten Howard, Natasha Nassar, Allison Jaure, Jonathan C. Craig, Germaine Wong