Article
Immunology
Bartlomiej J. Witczak, Soren E. Pischke, Anna Reisaeter, Karsten Midtvedt, Judith K. Ludviksen, Kristian Heldal, Trond Jenssen, Anders Hartmann, Anders Asberg, Tom E. Mollnes
Summary: Early complement activation, assessed by plasma TCC levels, is associated with impaired long-term patient and graft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Raphael Porret, Raphael P. H. Meier, Josip Mikulic, Manuel Pascual, Vincent Aubert, Thomas Harr, Dela Golshayan, Yannick D. D. Muller, Swiss Transplant Cohort Study
Summary: The study found that atopy is associated with better long-term patient and graft survival after kidney transplantation, independently of age and living donor donation. However, it does not affect the occurrence of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Urology & Nephrology
James Ashcroft, Philippa Leighton, Tegwen R. Elliott, Sarah A. Hosgood, Michael L. Nicholson, Vasilis Kosmoliaptsis
Summary: EVs have shown promise as therapeutic targets to improve kidney transplant outcomes and as potential biomarkers for accurate diagnosis of graft injuries. Research progress has been made, but challenges remain to be addressed, including methodological issues and clinical translation.
KIDNEY INTERNATIONAL
(2022)
Review
Transplantation
Dermot Michael Wildes, Caoimhe S. Costigan, Mairead Kinlough, Joan Flynn, Niamh Dolan, Michael Riordan, Clodagh Sweeney, Maria Stack, Mary Waldron, Orla Walsh, Kathleen M. Gorman, Atif Awan
Summary: Adolescence is a crucial period of transformation for patients, guardians, and clinicians. There is a lack of specific models for transitional care tailored to kidney transplant recipients. Further research and validation studies are needed to determine the optimal approach for providing effective transitional care to these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Computer Science, Artificial Intelligence
Samarra Badrouchi, Abdulaziz Ahmed, Mohamed Mongi Bacha, Ezzedine Abderrahim, Taieb Ben Abdallah
Summary: This study proposes a machine learning framework to predict graft survival after five years of kidney transplantation and determines the most influential parameters. The XGBoost algorithm was found to be the best model with high AUC and sensitivity. The framework can serve as a decision support system for Nephrologists to provide safer treatment recommendations and achieve positive kidney transplant outcomes.
EXPERT SYSTEMS WITH APPLICATIONS
(2021)
Article
Medicine, General & Internal
Joseba Salguero, Laura Chamorro, Enrique Gomez-Gomez, Patricia de Benito, Jose E. Robles, Juan P. Campos
Summary: Delayed graft function (DGF) development significantly contributes to graft loss in kidney transplants, particularly in grafts with KDRI >= 1.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Rongzhi Wang, Griffin Price, Mitchell Disharoon, Gabe Stidham, M. Chandler McLeod, Jessica Liu McMullin, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Song Ong, Herbert Chen
Summary: Persistent HPT is common after kidney transplantation and is associated with an increased risk of allograft failure. PTH levels should be closely monitored after transplantation to ensure appropriate treatment.
Article
Immunology
Zijian Zhang, Yan Qin, Yicun Wang, Shuai Li, Xiaopeng Hu
Summary: This study predicted the differential expression of monocytes associated with rejection by analyzing the transcriptome data of peripheral blood mononuclear cells. A novel gene, ISG15, was found to be associated with rejection and showed a critical role in promoting T cell proliferation. The results of this study have important implications for non-invasive diagnosis and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Mathilde Prezelin-Reydit, Valerie Dubois, Sophie Caillard, Anne Parissiadis, Isabelle Etienne, Francoise Hau, Laetitia Albano, Monique Pourtein, Benoit Barrou, Jean-Luc Taupin, Christophe Mariat, Lena Absi, Cecile Vigneau, Virginie Renac, Gwendaline Guidicelli, Jonathan Visentin, Pierre Merville, Olivier Thaunat, Lionel Couzi
Summary: Prospective serial monitoring of medication non-adherence using the Morisky scale does not predict the occurrence of de novo donor-specific antibodies (dnDSA), rejection, or graft failure in kidney transplant recipients. However, the use of cyclosporine and withdrawal of calcineurin inhibitors (CNI) were strongly associated with the development of dnDSA and rejection, leading to graft failure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Sandesh Parajuli, Aos. S. Karim, Brenda L. Muth, Glen. E. Leverson, Qiuyu Yang, Ravi Dhingra, Jason W. Smith, David P. Foley, Didier A. Mandelbrot
Summary: This study analyzed 1161 simultaneous heart and kidney transplant recipients using the OPTN/UNOS database, finding that factors such as history of pretransplant dialysis, donor death from cerebrovascular accident, and longer cold ischemia time were associated with the development of K-DGF. SHK recipients with K-DGF had increased mortality and death censored kidney graft failure.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Alex Christianson, Hitesh Kaul, Afshin Parsikia, Nikolaos Chandolias, Kamran Khanmoradi, Radi Zaki
Summary: This study explores the risk factors for delayed graft function (DGF) in recipients undergoing a second kidney transplant, as well as the short-term graft and patient survival of DGF retransplants. The results show that DGF and graft loss due to acute rejection in the first transplant are predictors of reappearing DGF in the second transplant. Dialysis at the time of transplant is identified as the greatest risk factor for DGF in the second transplant. Additionally, there is a lower graft survival rate for retransplants with DGF.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Urology & Nephrology
Simon Ville, Marine Lorent, Clarisse Kerleau, Anders Asberg, Christophe Legendre, Emmanuel Morelon, Fanny Buron, Valerie Garrigue, Moglie Le Quintrec, Sophie Girerd, Marc Ladriere, Laetitia Albano, Antoine Sicard, Denis Glotz, Carmen Lefaucheur, Julien Branchereau, David Jacobi, Magali Giral
Summary: The study found a lower incidence of delayed graft function in patients whose kidney clamping occurred between midnight and noon, while the declamping time was not associated with kidney graft outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Medicine, General & Internal
Sergi Codina, Anna Manonelles, Maria Tormo, Anna Sola, Josep M. Cruzado
Summary: Chronic kidney disease is on the rise globally, with kidney transplantation being the preferred choice for renal replacement therapy. Despite advancements, kidney allograft functional deterioration after transplantation remains a challenge. Clinical advances in improving long-term kidney allograft survival have been limited, indicating the need for new approaches and a holistic view to address CKaD.
FRONTIERS IN MEDICINE
(2021)
Article
Transplantation
Jutta S. Swolinsky, Ricarda M. Hinz, Carolin E. Markus, Eugenia Singer, Friederike Bachmann, Fabian Halleck, Susanne Kron, Marcel G. Naik, Danilo Schmidt, Martin Obermeier, Pimrapat Gebert, Geraldine Rauch, Siegfried Kropf, Michael Haase, Klemens Budde, Kai-Uwe Eckardt, Timm H. Westhoff, Kai M. Schmidt-Ott
Summary: This study investigated the utility of NGAL and CPT in predicting long-term graft survival in kidney transplant recipients. The results showed that NGAL had the best predictive ability for graft loss, with an AUC > 0.7 within 5 years. However, compared to the conventional marker eGFR, NGAL did not consistently provide added value.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pediatrics
Safaa M. Abdelrahman, Basma Samir, Eman Abobakr Abd Alazem, Noha Musa
Summary: Obesity is an independent risk factor for graft function and survival in pediatric kidney transplantation. Pre-transplant weight reduction is crucial in improving post-transplant outcomes.