Letter
Medicine, General & Internal
Brendon G. Neuen, Robert Fletcher, Hiddo J. L. Heerspink
Summary: The editorial suggests that the benefit of empagliflozin in slowing the progression of chronic kidney disease is less evident among patients who do not receive RAS blockade. This is because this subgroup only accounts for 15% of the overall trial population, resulting in less precise effect estimates and wider confidence intervals.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chao-Hsuan Wei, Chia-Hsiang Li, Te-Chun Shen, Yu-Tung Hung, Chih-Yen Tu, Te-Chun Hsia, Wu-Huei Hsu, Chung Y. Hsu
Summary: This nationwide retrospective cohort study found a significant association between pneumoconiosis and an increased risk of chronic kidney disease (CKD). The risk was even higher among patients with pneumoconiosis who also had hypertension, hyperglycemia, or hyperlipidemia.
Article
Medicine, General & Internal
Na Ri Kang, Yo Han Ahn, Eujin Park, Keum Hwa Lee, Hee Sun Baek, Seong Heon Kim, Heeyeon Cho, Min Hyun Cho, Jae Il Shin, Joo Hoon Lee, Hae Il Cheong, Hee Gyung Kang, Young Seo Park, Il-Soo Ha, Duk-Soo Moon, Kyoung Hee Han
Summary: This study investigated the intelligence levels and risk factors for low intelligence in children and adolescents with CKD, finding that participants with short stature, failure to thrive, more severe CKD stage, longer duration of CKD, and those who were Medicare or Medicaid beneficiaries had significantly lower intelligence levels. The association between intelligence and longer duration of CKD and growth failure remained significant after controlling for demographic and clinical variables, highlighting the importance of early interventions such as kidney transplantation.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Urology & Nephrology
Johannes Ruhe, Jennifer Nadal, Barbara Barthlein, Heike Meiselbach, Ulla T. Schultheiss, Fruzsina Kotsis, Helena Stockmann, Vera Krane, Claudia Sommerer, Ivonne Loeffler, Turgay Saritas, Jan T. Kielstein, Thomas Sitter, Markus P. Schneider, Matthias Schmid, Christoph Wanner, Kai-Uwe Eckardt, Gunter Wolf, Martin Busch
Summary: Diabetes mellitus (DM) and chronic kidney disease (CKD) are known risk factors for cardiovascular disease and mortality. This study found that DM significantly increased the risk of cardiovascular and non-cardiovascular death, major adverse cardiovascular events, and hospitalization for heart failure in patients with moderate to severe CKD. The increased risk was similar in patients with CKD caused by cardiovascular/metabolic diseases and those with genuine CKD. Patients with DM and CKD caused by cardiovascular/metabolic diseases were particularly susceptible to heart failure.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Medicine, General & Internal
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Young Youl Hyun, Suah Sung, Soo Wan Kim
Summary: This study indicates that there is a clear association between low BMD and all-cause mortality in patients with nondialysis CKD. Osteoporosis is significantly associated with an increased risk of all-cause mortality, while osteopenia does not have a significant association. This suggests that the routine measurement of BMD may have additional benefits beyond predicting fracture risk in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Eun Mi Yang, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Kook-Hwan Oh, Ji Yong Jung, Young Youl Hyun, Soo Wan Kim
Summary: The study investigated the association of urinary angiotensinogen (UAGT) with renal outcomes in patients with non-dialysis chronic kidney disease (CKD). The results showed that high UAGT level is associated with adverse renal outcomes, which is influenced by certain clinical contexts. Further studies are needed to validate the predictive role of UAGT as a biomarker for renal outcomes in CKD.
Article
Cardiac & Cardiovascular Systems
Chan-Young Jung, Ga Young Heo, Jung Tak Park, Young Su Joo, Hyung Woo Kim, Hyunsun Lim, Tae Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Joongyub Lee, Soo Wan Kim, Yun Kyu Oh, Ji Yong Jung, Kook-Hwan Oh, Curie Ahn, Seung Hyeok Han
Summary: In Korean CKD patients, men are more likely to experience adverse cardiovascular events and death than women.
CLINICAL RESEARCH IN CARDIOLOGY
(2021)
Article
Clinical Neurology
Chang Min Heo, Dong Ah Lee, Kang Min Park, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Junghae Ko, Byeong Cheol Yoo, Bong Soo Park
Summary: This study evaluated the function of the glymphatic system in patients with early CKD using the DTI-ALPS index, finding a lower index in CKD patients compared to healthy controls. However, there was no significant correlation between the DTI-ALPS index and other clinical factors.
FRONTIERS IN NEUROLOGY
(2022)
Article
Urology & Nephrology
Jan Dominik Kampmann, James Goya Heaf, Christian Backer Mogensen, Hans Mickley, Donna Lykke Wolff, Frans Brandt
Summary: Only a small fraction of chronic kidney disease (CKD) patients are followed by nephrologists, despite the importance of specialist follow-up for disease management and prevention.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Transplantation
Cynthia J. Janmaat, Merel van Diepen, Yvette Meuleman, Nicholas C. Chesnaye, Christiane Drechsler, Claudia Torino, Christoph Wanner, Maurizio Postorino, Maciej Szymczak, Marie Evans, Fergus J. Caskey, Kitty J. Jager, Friedo W. Dekker, Equal Study Investigators
Summary: The study found that faster kidney function decline in advanced CKD patients was associated with a steeper increase in both the number and severity of symptoms. It is important to pay attention to symptom development in addition to monitoring kidney function decline during clinical decision-making.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Magda Wisniewska, Natalia Serwin, Violetta Dziedziejko, Malgorzata Marchelek-Mysliwiec, Barbara Dolegowska, Leszek Domanski, Kazimierz Ciechanowski, Krzysztof Safranow, Andrzej Pawlik
Summary: Levels of renalase in serum and urine were significantly elevated in haemodialysis CKD patients, while levels in erythrocytes were lower. Plasma concentrations of dopamine, adrenaline, and noradrenaline were also decreased in CKD patients. These changes may be related to compensatory production in extrarenal organs and altered degradation by plasma renalase.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chun-Fung Sin, Ka-Ping Wong, Hoi-Man Wong, Chung-Wah Siu, Desmond Y. H. Yap
Summary: This study investigated the plasma levels of rivaroxaban in early CKD patients and its relationship with clinical events. The results showed that plasma trough levels of rivaroxaban were higher in CKD patients and inversely correlated with renal function. Additionally, there was an association between plasma trough levels of rivaroxaban and the rate of bleeding complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Seung Hyeok Han, Seong Kwon Ma, Soo Wan Kim
Summary: This study found that high serum triglycerides levels are independently associated with adverse renal outcomes in patients with non-dialysis chronic kidney disease.
FRONTIERS IN NUTRITION
(2022)
Article
Substance Abuse
Sangmi Lee, Shinchan Kang, Young Su Joo, Changhyun Lee, Ki Heon Nam, Hae-Ryong Yun, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Soo Wan Kim, Kook-Hwan Oh, Yeong Hoon Kim, Sue K. Park, Shin-Wook Kang, Kyu Hun Choi, Curie Ahn, Seung Hyeok Han
Summary: The study found a significant association between smoking and worsening kidney function in CKD patients, with higher pack-years of smoking correlating with higher risk of adverse kidney outcomes. Quitting smoking was shown to potentially delay CKD progression, suggesting it is a modifiable factor in managing the disease.
NICOTINE & TOBACCO RESEARCH
(2021)
Review
Health Care Sciences & Services
Maja Mizdrak, Marko Kumric, Tina Ticinovic Kurir, Josko Bozic
Summary: Chronic kidney disease (CKD) is a global health problem that requires early diagnosis and treatment. However, the lack of early and noninvasive biomarkers has hindered the prompt detection and treatment of this condition. This review provides insight into diagnostic methods for early detection of CKD, including markers of glomerular and tubulointerstitial injury, omics, microbiota, and microRNA.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
