Article
Cardiac & Cardiovascular Systems
Diego Medvedofsky, Genevieve Arany-Lao-Kan, Scott McNitt, Roberto M. Lang, Roderick Tung, Scott D. Solomon, Bela Merkely, Ilan Goldenberg, Valentina Kutyifa
Summary: This study aimed to evaluate the predictive value of left ventricular global longitudinal strain (LV GLS) in HF patients with different LVEF. The results showed that higher LV GLS was associated with higher risk of VT/VF, HF/death in patients with LVEF <= 30%, but not in patients with LVEF > 30%.
Article
Cardiac & Cardiovascular Systems
Jan Stassen, Gurpreet K. Singh, Stephan M. Pio, Suren Chimed, Steele C. Butcher, Kensuke Hirasawa, Nina Ajmone Marsan, Jeroen J. Bax
Summary: This study investigated the prognostic value of LV global longitudinal strain (GLS) in patients with moderate AS and reduced LV systolic dysfunction. The results showed that patients with LVGLS <11% had higher 1-year and 5-year mortality rates compared to patients with LVGLS >= 11%. LVGLS was independently associated with outcomes, while LVEF was not. Therefore, LVGLS has independent prognostic value in patients with moderate AS and reduced LV systolic dysfunction.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gulinu Maimaituxun, Kenya Kusunose, Hirotsugu Yamada, Daiju Fukuda, Shusuke Yagi, Yuta Torii, Nao Yamada, Takeshi Soeki, Hiroaki Masuzaki, Masataka Sata, Michio Shimabukuro
Summary: Increased epicardial adipose tissue volume is independently associated with global longitudinal strain, especially in the absence of obstructive coronary artery disease. This suggests an additional role of epicardial adipose tissue on myocardial systolic function through impaired left ventricular longitudinal strain.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Brian P. Halliday, Roxy Senior, Dudley J. Pennell
Summary: The measurement of left ventricular ejection fraction (LVEF) has been a key component in imaging studies for cardiac patients, but its utility as a prognostic indicator has diminished in certain populations such as heart failure patients with preserved ejection fraction (HF-PEF) and those with valvular heart disease. Assessing myocardial strain, particularly global longitudinal strain (GLS), holds promise in improving risk stratification and therapy selection for these patients. Additional studies are needed to fully integrate GLS into routine clinical practice and improve patient outcomes.
EUROPEAN HEART JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Brian P. Halliday, Roxy Senior, Dudley J. Pennell
Summary: Traditional methods of assessing cardiac function like LVEF are no longer accurate in predicting prognosis for heart failure patients, highlighting the need for better indicators such as GLS to improve risk stratification and accuracy of disease assessment. For patients with heart failure and valvular heart disease, GLS may be a superior option to consider.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Seon Hwa Lee, Purevjargal Lhagvasuren, Jiwon Seo, Iksung Cho, Dae-Young Kim, Geu-Ru Hong, Jong-Won Ha, Chi Young Shim
Summary: This study found that assessing LV global longitudinal strain (LV-GLS) can provide functional information associated with cardiovascular outcomes in patients with surgically treated mitral valve disease. Patients with lower LV-GLS values were more likely to experience heart-related clinical events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jessica Mao, Eric Xie, Ela Chamera, Joao A. C. Lima, Jonathan Chrispin
Summary: The study aimed to use CMR to evaluate changes in cardiac structure and function of PVC CM patients following catheter ablation. PVC origin in the RV was associated with persistently reduced LVEF after ablation, while scar burden was not correlated with cardiac function or post-ablation recovery of function.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Sun-Hack Lee, Jin Kyung Oh, Seung-Ah Lee, Do-Yoon Kang, Sahmin Lee, Ho Jin Kim, Jung-Min Ahn, Joon Bum Kim, Duk-Woo Park, Jong-Min Song, Suk Jung Choo, Duk-Hyun Kang, Jae-Kwan Song, Seung-Jung Park, Jung Hyun Choi, Dae-Hee Kim
Summary: Evaluation of LVGLS can independently predict clinical outcomes in patients with severe aortic stenosis and preserved LVEF undergoing TAVI, providing incremental prognostic value above echocardiographic parameters.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2022)
Article
Cardiac & Cardiovascular Systems
Caterina Maffeis, Andrea Rossi, Lorenzo Cannata, Camilla Zocco, Evgeny Belyavskiy, Aravind Kumar Radhakrishnan, Anna Feuerstein, Daniel Armando Morris, Elisabeth Pieske-Kraigher, Burkert Pieske, Frank Edelmann, Pier Luigi Temporelli
Summary: Impaired left atrial function is associated with reduced exercise capacity in patients with chronic heart failure. Left atrial dysfunction can serve as a prognostic marker for poor outcomes in patients with chronic heart failure.
Article
Cardiac & Cardiovascular Systems
Anne G. Raafs, Andrea Boscutti, Michiel T. H. M. Henkens, Wout W. A. van den Broek, Job A. J. Verdonschot, Jerremy Weerts, Davide Stolfo, Vincenzo Nuzzi, Paolo Manca, Mark R. Hazebroek, Christian Knackstedt, Marco Merlo, Stephane R. B. Heymans, Gianfranco Sinagra
Summary: In patients with optimally treated DCM, GLS emerged as an independent and incremental predictor of adverse outcomes, surpassing LVEF. Therefore, it is necessary to routinely include GLS in the echocardiographic follow-up of DCM patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
You-Jung Choi, Hyun-Jung Lee, Ji-Suck Park, Chan Soon Park, Tae-Min Rhee, Jah Yeon Choi, Hong-Mi Choi, Jun-Bean Park, Yeonyee E. Yoon, Seung-Pyo Lee, Jin Oh Na, Goo-Yeong Cho, Yong-Jin Kim, In-Chang Hwang, Hyung-Kwan Kim
Summary: The aim of this study was to investigate the prognostic utility of left ventricular global longitudinal strain (LV-GLS) in patients with hypertrophic cardiomyopathy (HCM) and a left ventricular ejection fraction (LVEF) of 50-60%. The study included 349 HCM patients with an LVEF of 50-60%, and the results showed that LV-GLS was an independent predictor of a composite outcome including cardiovascular death in these patients. Therefore, LV-GLS can aid in risk stratification in HCM patients with an LVEF of 50-60%.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Hack-Lyoung Kim, Woo-Hyun Lim, Jae-Bin Seo, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Summary: This study retrospectively reviewed subjects without overt cardiovascular disease and found that a relevant proportion exhibited reduced GLS, which was significantly associated with cardiovascular risk factors such as male sex, hypertension, and cigarette smoking.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Nikos T. Kouris, Vassilis S. Kostopoulos, Georgia A. Psarrou, Peggy M. Kostakou, Chara Tzavara, Christoforos D. Olympios
Summary: The aim of this study was to test the inter-observer variability of EF and GLS measurement in patients with a broad spectrum of LV function, between physicians and investigators (Inv) with different levels of expertise. The results showed that the agreement in GLS measurement was excellent, while that in EF was slightly lower.
ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES
(2021)
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
J. Jiang, B. Liu, Y. W. Li, S. S. Hothi
Summary: Cardiotoxicity is a potential complication of chemotherapy that may lead to heart failure. AI-based cardiac imaging shows promise but faces challenges. This study aims to evaluate the feasibility and correlation of AI-automated analysis compared to conventional methods for assessing left ventricular systolic function, and the results show moderate to good correlation between the two approaches.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Critical Care Medicine
Cienwen J. Town, Haakan Strand, James Johnson, Andre Van Zundert
Summary: This study evaluated the impact of ultrasound-guided regional nerve block on pain scores in patients requiring dressing changes for hand and upper limb burn injuries. The results demonstrated that the addition of ultrasound-guided regional anesthesia significantly reduced pain in patients undergoing dressing changes, without any adverse events.
JOURNAL OF BURN CARE & RESEARCH
(2023)
Article
Transplantation
Mark K. Tiong, Edward R. Smith, Elaine M. Pascoe, Grahame J. Elder, Nicole M. Lioufas, Eugenia Pedagogos, Carmel M. Hawley, Andrea Valks, Stephen G. Holt, Tim D. Hewitson, Nigel D. Toussaint
Summary: This study investigated the impact of lanthanum carbonate on serum calciprotein particles (CPP) in patients with early-stage chronic kidney disease (CKD). The results suggest that lanthanum carbonate is not effective in reducing CPP levels at 96 weeks compared with placebo.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Ashik Hayat, David W. Johnson, Carmel M. Hawley, Lauren R. Jaffrey, Usman Mahmood, Sarah Saw Yu Mon, Yeoungjee Cho
Summary: This study aimed to compare the associations, microbiologic profiles, and outcomes between pre-training peritonitis (PTP) and post-training peritonitis in patients with kidney failure. The results showed that PTP was closely associated with prior exit-site infection, often had culture-negative peritonitis, and was associated with worse outcomes of hemodialysis transfer or death.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Urology & Nephrology
Wai H. Lim, Jenny H. C. Chen, Kimberley Minas, David W. Johnson, Maleeka Ladhani, Esther Ooi, Neil Boudville, Carmel Hawley, Andrea K. Viecelli, Matthew Roberts, Kate Wyburn, Rachael Walker, Monique Borlace, Helen Pilmore, Christopher E. Davies, Charmaine E. Lok, Armando Teixeira-Pinto, Germaine Wong
Summary: This study investigates the cause-specific mortality rates between male and female dialysis patients in Australia and New Zealand from 1998 to 2018. It found that female patients had a higher risk of all-cause mortality in the first 5 years after dialysis initiation, primarily due to mortality from infections and dialysis withdrawals.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
Summary: This study found that smoking is associated with increased rates of all-cause mortality, cardiovascular mortality, respiratory failure, chronic lung disease, and malignancy in dialysis patients. It also increases the risk of non-skin cancers, de novo vascular disease, and chronic lung disease.
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Stephen J. Foulkes, Erin J. Howden, Mark J. Haykowsky, Yoland Antill, Agus Salim, Sophie S. Nightingale, Sherene Loi, Piet Claus, Kristel Janssens, Amy M. Mitchell, Leah Wright, Ben T. Costello, Anniina Lindqvist, Lauren Burnham, Imogen Wallace, Robin M. Daly, Steve F. Fraser, Andre La Gerche
Summary: Exercise training for 12 months in breast cancer survivors receiving anthracycline-based chemotherapy can improve cardiorespiratory fitness and prevent cardiac dysfunction, but does not have a lasting effect on functional disability.
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Katharine Hegerty, Allison Jaure, Nicole Scholes-Robertson, Kirsten Howard, Angela Ju, Nicole Evangelidis, Martin Wolley, Amanda Baumgart, David W. Johnson, Carmel M. Hawley, Donna Reidlinger, Laura Hickey, Alyssa Welch, Yeoungjee Cho, Peter G. Kerr, Matthew A. Roberts, Jenny I. Shen, Jonathan Craig, Rathika Krishnasamy, Andrea K. Viecelli
Summary: This study aimed to explore patients' perspectives on incremental hemodialysis (HD) and their priorities and concerns regarding HD. The study found that patients with kidney failure preferred incremental initiation of HD to minimize disruption to daily living and improve quality of life. The top prioritized outcomes were quality of life, residual kidney function, and mortality.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Transplantation
Gregory J. Wilson, Kim Van, Emma O'Lone, Allison Tong, Jonathan C. Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G. Herrington, Tazeen H. Jafar, David W. Johnson, Vera Krane, Adeera Levin, Jolanta Malyszko, Patrick Rossignol, Deirdre Sawinski, Nicole Scholes-Robertons, Giovanni Strippoli, Angela Wang, Wolfgang C. Winkelmayer, Carmel M. Hawley, Andrea K. Viecelli
Summary: This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients, revealing substantial heterogeneity in cardiovascular outcome reporting.
TRANSPLANTATION DIRECT
(2023)
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, James P. Macnamara, Michinari Hieda, Erin J. Howden, Justin S. Lawley, Sheryl Livingston, Mitchel Samels, Benjamin D. Levine
Summary: This study investigated the effects of istaroxime on cardiac function during exercise in patients with HFpEF. The results showed that low-dose istaroxime had no effect on cardiac filling pressure or parameters of relaxation in patients with HFpEF during exercise, while higher doses of istaroxime may have been more effective in reducing exercise PCWP in patients with HFpEF.
JACC-HEART FAILURE
(2023)
Review
Cardiac & Cardiovascular Systems
Adrian D. Elliott, Jonathan Ariyaratnam, Erin J. Howden, Andre La Gerche, Prashanthan Sanders
Summary: The left atrium (LA) plays a critical role in receiving pulmonary venous return and modulating left ventricular filling, with its function contributing to the augmentation in stroke volume during exercise. Structural remodeling and dysfunction of the LA are associated with adverse outcomes in cardiovascular disease, leading to exercise intolerance and increased risk of hospital admissions and mortality. Exercise training is recommended in patients with cardiovascular disease to improve outcomes and maintain functional capacity, with less attention given to the changes in LA structure and function compared to the left ventricle.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Peripheral Vascular Disease
Rachel E. Climie, Hayley T. Dillon, Yuki Horne-Okano, Imogen Wallace, Sharon Avery, Bronwyn A. Kingwell, Andre La Gerche, Erin J. Howden
Summary: This study provides evidence of an accelerated vascular aging phenotype in allogeneic SCT survivors and provides insight into the increased burden of cardiovascular disease among hematologic cancer survivors.
Correction
Critical Care Medicine
Cienwen J. Town, Haakan Strand, James Johnson, Andre Van Zundert
JOURNAL OF BURN CARE & RESEARCH
(2023)