Journal
NEONATOLOGY
Volume 110, Issue 3, Pages 172-180Publisher
KARGER
DOI: 10.1159/000445708
Keywords
Neonatal jaundice; Severe hyperbilirubinemia; Acute bilirubin encephalopathy; Kernicterus; Low-; and middle-income countries
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Funding
- Fondazione Italiana Fegato (FIF)
- US Agency for International Development (USAID)
- government of Norway
- Bill & Melinda Gates Foundation
- Grand Challenges Canada
- UK government (FOG award) [AID-OAA-F-13-00072]
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Severe neonatal hyperbilirubinemia, defined as total serum bilirubin (TSB) >= 20 mg/dl, is associated with a higher risk of permanent neurological sequelae and death. Jaundice can and should be promptly diagnosed and treated. Reliable methods for TSB assay are not always readily available, particularly in low- and middle-income countries, making the true incidence of severe neonatal jaundice (NNJ) difficult to estimate. To gather a more comprehensive picture, a symposium addressing NNJ worldwide was organized during the 2015 Don Ostrow Trieste Yellow Retreat. Data collected by several researchers in different regions of the world were presented and differences/similarities discussed. This report points out the need for: (1) a coordinated worldwide effort to define the burden and the causes of severe NNJ and its consequences; (2) aggressive educational programs for families and health personnel to facilitate timely care-seeking, and (3) accurate diagnostics and effective phototherapy. (C) 2016 S. Karger AG, Basel
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