Hsp70 chaperones use ATP to remodel native protein oligomers and stable aggregates by entropic pulling

Experimental Milestones in the Discovery of Molecular Chaperones as Polypeptide Unfolding Enzymes

(2016) Andrija Finka et al.   Annual Review of Biochemistry

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

(2016) Rui Sousa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Clathrin-coat disassembly illuminates the mechanisms of Hsp70 force generation

(2016) Rui Sousa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs

(2015) Andrija Finka et al.   CELL STRESS & CHAPERONES

Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation

(2015) Nadinath B. Nillegoda et al.   NATURE

Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo

(2015) D. H. Goldman et al.   SCIENCE

Hsp70 chaperones are non-equilibrium machines that achieve ultra-affinity by energy consumption

(2014) Paolo De Los Rios et al.   eLife

Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates

(2013) Rayees U. H. Mattoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes

(2013) Botao Liu et al.   MOLECULAR CELL

Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding

(2010) T. Hagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly

(2009) Yi Xing et al.   EMBO JOURNAL