Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 11, Pages 952-954Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3318
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A conserved long noncoding RNA expressed at the 5S rDNA ribosomal locus has acquired a novel function in alternative splicing regulation in primates, owing to the insertion of a mobile Alu element. This discovery opens new perspectives regarding the roles of transposable elements in expanding the human transcriptome and may be applied as a biotechnology tool to drive gene-specific changes in alternative splicing.
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