Review
Medicine, General & Internal
Ahmed ElSayed Galhoum, Vineet Trivedi, Mohamed Askar, Sergio Tejero, Mario Herrera-Perez, Yousef AlRashidi, Victor Valderrabano
Summary: This review focuses on the management protocols of ankle Charcot neuroarthropathy, with different surgical and non-surgical options discussed. Surgical interventions are primarily based on instability and ulceration as precursors, and further research is needed to support current practice.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Petra J. Jones, Melanie J. Davies, David Webb, Rachel Berrington, Robert G. Frykberg
Summary: This study aimed to investigate the measurement method of contralateral temperature difference (CTD) and the decision-making process for cessation of immobilisation in Charcot neuro-osteoarthropathy (CN). The results showed variations in average CTD and its relationship with healing markers. The threshold CTD for cessation of immobilisation was generally < 2°C sustained for 2-3 visits. Standardisation of thermometry device, accuracy, foot resting times, and ambient temperature reporting is crucial for comparisons and evaluations.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Medicine, General & Internal
Mateo Lopez-Moral, Raul J. Molines-Barroso, Irene Sanz-Corbalan, Aroa Tardaguila-Garcia, Marta Garcia-Madrid, Jose Luis Lazaro-Martinez
Summary: Weight-bearing lateral X-ray can be used to predict the probability of ulceration in patients with midfoot Charcot neuroarthropathy (CN), with differences observed based on lateral and medial column deformities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Ahmed E. Galhoum, Mohamed M. Abd-Ella, Hany El Zahlawy, Sergio Tejero, Victor Valderrabano, Vineet Trivedi, Mohamed ElGebeily
Summary: In this study, aggressive debridement and Ilizarov frame fusion were used to salvage severely infected Charcot neuroarthropathy of the ankle. The results showed successful limb salvage in the majority of cases, with stable bony unions achieved and patients able to walk pain-free.
INTERNATIONAL ORTHOPAEDICS
(2022)
Article
Surgery
Baozhou Zhang, Wenjing Li, Ying Li, Hui Du, Yong Wu
Summary: The supramalleolar osteotomy (SMO) procedure can be considered as an option for young patients with Charcot neuroarthropathy (CN) who do not want to undergo arthrodesis. This procedure can help correct hindfoot malalignment and improve ankle stability, leading to improvements in pain, deformity, and functionality. The patient in this case study experienced satisfactory outcomes with improved quality of life.
FRONTIERS IN SURGERY
(2023)
Review
Endocrinology & Metabolism
Renata Ochoa-Precoma, Blanca T. Pacheco-Soto, Leonardo M. Porchia, Enrique Torres-Rasgado, Ricardo Perez-Fuentes, M. Elba Gonzalez-Mejia
Summary: This study found that serum OPG concentrations were higher in CN patients, with a more significant difference compared to healthy controls than diabetics. Among the OPG polymorphisms, only the CC genotype of the 245A > C polymorphism was associated with an increased risk of developing CN.
ACTA DIABETOLOGICA
(2021)
Review
Surgery
Mohd Yazid Bajuri, Shir Lee Ong, Srijit Das, Isa Naina Mohamed
Summary: This study analyzed data published from January 2010 to January 2020 on surgical reconstruction methods for Charcot neuroarthropathy. The use of retrograde intramedullary nail and HA-coated screws are recommended for the reconstruction, as well as the application of hybrid fixation for more complex deformities.
FRONTIERS IN SURGERY
(2022)
Review
Orthopedics
Fengyao Mei, Jiao Jiao Li, Jianhao Lin, Diange Zhou, Dan Xing
Summary: This case report presents a 74-year-old Asian woman with bilateral Charcot knees who underwent bilateral knee replacements and experienced pain relief and improved range of motion after 2 years without postoperative complications or prosthesis loosening.
ORTHOPAEDIC SURGERY
(2023)
Article
Endocrinology & Metabolism
Mateo Lopez-Moral, Raul J. Molines-Barroso, Esther Garcia-Morales, Yolanda Garcia-Alvarez, Francisco Javier Alvaro-Afonso, JoseLuis Lazaro-Martinez
Summary: The study aimed to identify an optimal cut-off point for peak plantar midfoot pressure to screen for neuropathic ulceration in patients with Charcot neuroarthropathy. Results showed that patients with higher PPP and PTI values were more likely to develop midfoot ulcers.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Clinical Neurology
Barbara Limberger Nedel, Juliana Avila Duarte, Fernando Gerchman
Summary: Spinal neuroarthropathy (SNA), also known as Charcot spine, is a rare aggressive arthropathy secondary to loss of spinal proprioceptive and nociceptive feedback. Early diagnosis is crucial as symptoms are scarce in the initial stages, and MRI findings play a key role in proper diagnosis. This case highlights the importance of early suspicion and MRI assessment for prompt intervention and prevention of further neurological impairment in SNA.
Review
Medicine, General & Internal
Yu Lu, Jun-Yi Xiang, Cheng-Yu Shi, Ju-Bao Li, Hai-Chao Gu, Chang Liu, Guo-Yu Ye
Summary: This is a case report of Charcot neuroarthropathy (CN) of the hip caused by syringomyelia secondary to cervical spondylotic myelopathy (CSM). The authors suggest a possible etiological association between CSM and syringomyelia, and emphasize the importance of a detailed medical history and comprehensive physical and imaging examinations in the early diagnosis of CN.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Neurosciences
Xiao-hui Xie, Jian-guang Tang, Zhong-hua Liu, Shui-jiao Peng, Zhuang-zhuang Yuan, Heng Gu, Yi-qiao Hu, Zhi-ping Tan
Summary: Charcot neuroarthropathy associated with CIP has a wider spectrum than previously recognized, and the novel SCN9A mutation identified in this study contributes to understanding critical amino acids for maintaining Nav1.7 function, which is valuable for the development of Nav1.7-targeted analgesics.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
William Jeffcoate, Fran Game
Summary: This article emphasizes the importance of the inflammation process in the development and resolution of neuropathic osteoarthropathy, pointing out that the interaction between neuropathy and inflammation is essential for the occurrence of Charcot foot.
Review
Orthopedics
D. Diacogiorgis, B. M. Perrin, M. I. C. Kingsley
Summary: The effective delivery of evidence-based assessment, diagnosis, and management of acute CN is impacted by factors related to patient awareness, practitioner knowledge, and geographical barriers. Delayed diagnosis is influenced by patients' and practitioners' knowledge, confusion in imaging and offloading, as well as access to local health resources.
JOURNAL OF FOOT AND ANKLE RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leah E. Waldman, Max P. Michalski, Joseph C. Giaconi, Glenn B. Pfeffer, Thomas J. Learch
Summary: Charcot-Marie-Tooth disease (CMT) is a common genetic disorder that affects peripheral nerves, causing motor and sensory deficiencies. This disease often leads to a specific foot and ankle deformity, known as a cavovarus deformity, which can severely impact mobility and stability. Imaging techniques such as radiography, weight-bearing CT, MRI, and ultrasound are crucial for evaluating and treating CMT, as there is a wide range of phenotypic variation. Surgical correction, including soft-tissue releases, tendon transfers, osteotomies, and arthrodesis, may be necessary to create a stable foot and improve function. The information discussed in this article may also be applicable to similar deformities caused by idiopathic or other neuromuscular conditions.
