Article
Rehabilitation
Chunyan Xu, Yong Nie, Chaowei Tan, Yi Zeng, HaiBo Si, ZongKe Zhou, Bin Shen, Weiwei Song, Kang Li
Summary: This study elucidated the association of lower limb muscle strength with volume loss of cartilages/menisci for patients with mild and moderate knee osteoarthritis. The results showed that decreased quadricep strength was more positively correlated with lateral meniscus volume, indicating a biomechanical mechanism in knee osteoarthritis progression.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2022)
Article
Nutrition & Dietetics
Welma Stonehouse, Bianca Benassi-Evans, Jana Bednarz, Andrew D. Vincent, Stephen Hall, Catherine L. Hill
Summary: This study showed that a commercially available krill oil supplement can improve knee pain, stiffness, and physical function in adults with mild to moderate knee osteoarthritis. The supplement is safe to consume.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Orthopedics
W. Wu, A. L. Bryant, R. S. Hinman, K. L. Bennell, B. R. Metcalf, M. Hall, P. K. Campbell, K. L. Paterson
Summary: Medial and lateral knee contact forces (KCFs) differ across grades of radiographic knee osteoarthritis (OA) severity, but are not associated with knee pain severity. Medial KCFs during early and middle stance are higher in participants with moderate and severe OA compared to mild OA. In contrast, lateral KCFs are higher in mild OA during middle to late stance. The external loading component (KAM) of medial KCF during middle to late stance is greater in participants with moderate and severe OA, while the internal (muscle) component is greater in participants with moderate and severe OA during early stance. There are no associations between medial KCF and knee pain in any radiographic OA grade.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Medicine, General & Internal
Wing Chung Lam, Kwok Yin Au, Zongshi Qin, Fung Man Wu, Chiu On Chong, Fei Jiang, Yue He, Bacon Fung Leung Ng, Wing-Fai Yeung, Lixing Lao, Haiyong Chen
Summary: In the treatment of knee osteoarthritis, 4 weeks of superficial acupuncture is not superior to non-penetrating sham acupuncture.
AMERICAN JOURNAL OF MEDICINE
(2021)
Article
Orthopedics
Mustafa Ibrahim, Khaled Meknas, Sonja E. Steigen, Randi Olsen, Ninni Sernert, Lars Ejerhed, Juri-Toomas Kartus
Summary: The study investigated periarticular degenerative changes in the knee joint associated with osteoarthritis. Samples from 41 patients were examined, with no significant differences found between patients with and without mild to moderate OA in terms of histological and morphological features of the semitendinosus tendon. Electron microscope results showed no increase in degenerative changes in the tendon of OA patients.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Engineering, Biomedical
Sirui Liu, Pouya Amiri, Alison H. McGregor, Anthony M. J. Bull
Summary: Most cases of unilateral knee osteoarthritis (OA) progress to bilateral OA within 10 years. However, gait analysis alone does not consistently detect asymmetries in OA patient gait. Stair ambulation is a more demanding activity that may reveal between-leg biomechanical differences in OA patients. The study found that OA patients rely more on their unaffected limbs during stair ascent, potentially leading to negative effects on the unaffected joint health.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Health Care Sciences & Services
Vilim Molnar, Eduard Pavelic, Zeljko Jelec, Petar Brlek, Vid Matisic, Igor Boric, Damir Hudetz, Eduard Rod, Dinko Vidovic, Neven Starcevic, Martin Cemerin, David C. Karli, Dragan Primorac
Summary: The clinical and radiological findings after the application of autologous conditioned adipose tissue (ACA) and leukocyte-poor PRP (LP-PRP) in patients with mild to moderate knee osteoarthritis (KOA) were evaluated. Significant improvements were observed at three and six months post-intervention. Therefore, ACA with LP-PRP is a viable minimally invasive therapeutic option for the clinical improvement of mild to moderate KOA.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Wenjie Xu, Yu Xiao, Minzhi Zhao, Jiahui Zhu, Yu Wang, Wenbin Wang, Peng Wang, Huan Meng
Summary: A nano-enabled drug delivery acupuncture technology (nd-Acu) has been developed using traditional acupuncture needles modified with cyclodextrin to deliver payload molecules efficiently. The nd-Acu platform allows time-dependent release of loaded molecules and has been tested for the treatment of knee osteoarthritis (KOA) using lidocaine. The study shows that lidocaine-laden nd-Acu effectively alleviates pain, reduces inflammation, and slows down KOA development, potentially through modulation of the HMGB1/TLR4 signaling pathway.
Article
Biochemistry & Molecular Biology
Dawid Szwedowski, Ali Mobasheri, Andrzej Moniuszko, Jan Zabrzynski, Slawomir Jeka
Summary: In patients with knee osteoarthritis, it was found that those receiving PRP treatment showed significant functional improvement within 6 months, which was superior to treatment with HA or CS; in terms of pain reduction, the CS group performed the best, but the effect decreased gradually in subsequent visits.
Article
Pharmacology & Pharmacy
Parnnaphat Luksameesate, Aree Tanavalee, Suthira Taychakhoonavudh
Summary: The study demonstrated that adding crystalline glucosamine sulfate in the standard knee OA care sequence was the most cost-effective strategy in the perspective of major health insurance payer in Thailand. Additionally, early initiation of crystalline glucosamine sulfate was found to be less costly and more effective than delayed treatment or standard treatment alone.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Rheumatology
Jian-Feng Tu, Jing-Wen Yang, Guang-Xia Shi, Zhang-Sheng Yu, Jin-Ling Li, Lu-Lu Lin, Yu-Zheng Du, Xiao-Gang Yu, Hui Hu, Zhi-Shun Liu, Chun-Sheng Jia, Li-Qiong Wang, Jing-Jie Zhao, Jun Wang, Tong Wang, Yang Wang, Tian-Qi Wang, Na Zhang, Xuan Zou, Yu Wang, Jia-Kai Shao, Cun-Zhi Liu
Summary: The study found that intensive EA can reduce pain and improve function in patients with knee OA, with long-lasting effects. Intensive MA, on the other hand, showed no benefit for knee OA at week 8, but exhibited some benefits during follow-up.
ARTHRITIS & RHEUMATOLOGY
(2021)
Review
Medicine, General & Internal
Xunlong Yin, Yuan Liu, Wu Liu, Wei Liang, Qingyong Liang
Summary: This study conducted a meta-analysis comparing the efficacy of blade needle therapy with conventional acupuncture for the treatment of knee osteoarthritis (KOA). The results showed that blade needle therapy was more effective than conventional acupuncture. However, more high-quality studies are needed to validate these findings due to the limited inclusion of high-quality studies and potential bias.
Article
Clinical Neurology
Nan Gao, Haiping Shi, Sheng Hu, Bixiang Zha, Aihong Yuan, Jianhua Shu, Yinqiu Fan, Jin Bai, Hongyu Xie, Jingcheng Cui, Xiaoxiao Wang, Chuanfu Li, Bensheng Qiu, Jun Yang
Summary: This study found that acupuncture can enhance functional connectivity between the dorsal raphe nucleus (RPN) and the right putamen in patients with knee osteoarthritis (KOA), which is related to the intensity of chronic pain. This result suggests that acupuncture can improve the perception of pain in patients with KOA by stimulating neural mechanisms in the brain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biophysics
Sevtap Gunay Ucurum, Muge Kirmizi, Elif Umay Altas, Derya Ozer Kaya
Summary: Recent studies have shown that patients with lower extremity osteoarthritis may have altered spinal posture. This study investigated the impact of sagittal spinal alignment on physical function of women over 40 years old with mild-to-moderate knee osteoarthritis. It found that women with knee osteoarthritis had higher thoracic kyphosis and lumbar lordosis compared to asymptomatic women, and that spinal alignment and mobility were related to physical function in asymptomatic women.
JOURNAL OF BIOMECHANICS
(2023)
Article
Medicine, Research & Experimental
Yiniu Chang, Nan Wu, Zhenhua Zhang, Zhaoyang Zhang, Binbin Ren, Feilai Liu, Xiaolei Song, Mingli Wu, Xiaodong Feng, Shuai Yin
Summary: This study aims to compare the clinical effects of manual acupuncture, electro-acupuncture, and warm acupuncture on knee osteoarthritis through a randomized controlled trial, and establish standardized treatment programs for acupuncture for knee osteoarthritis.
