Article
Genetics & Heredity
Longfei Dai, Xu Wang, Tao Bai, Jianjun Liu, Bo Chen, Wenqi Yang
Summary: This study aimed to explore the effect of cellular senescence on gastric cancer and identify potential therapeutic strategies. By using cellular senescence-related genes and gastric cancer data, a prognostic risk score signature was constructed. The results showed that patients in the low-risk score group had longer survival time and were more sensitive to chemotherapy and immunotherapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yanping Lyu, Shuangfeng Yang, Xuejie Lyu, Yuan-Liang Wang, Shumi Ji, Shuling Kang, Yu Jiang, Jianjun Xiang, Chenzhou He, Peixin Li, Baoying Liu, Chuancheng Wu
Summary: This study reveals the association between genetic polymorphism of lncRNA and the prognosis of gastric cancer, suggesting that it can serve as a predictor for GC prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Peter Larsson, Daniella Pettersson, Hanna Engqvist, Elisabeth Werner Ronnerman, Eva Forssell-Aronsson, Aniko Kovacs, Per Karlsson, Khalil Helou, Toshima Z. Parris
Summary: The study analyzed the genetic alterations and prognostic value of PSM gene expression in various cancer types using TCGA data. High frequency of PSM genetic alterations, especially DNA amplification, was observed in certain cancer types. Overexpression of most PSM genes in cancer and their association with adverse clinical outcomes were also reported.
Article
Oncology
Zhengxin Wu, Jinshui Tan, Yifan Zhuang, Mengya Zhong, Yubo Xiong, Jingsong Ma, Yan Yang, Zhi Gao, Jiabao Zhao, Zhijian Ye, Huiwen Zhou, Yuekun Zhu, Haijie Lu, Xuehui Hong
Summary: The study revealed dysregulation of pyrimidine metabolism in GC and established a prognostic model based on differentially expressed genes in pyrimidine metabolism, confirming the reliability and independence of the model. Additionally, nomograms were created to visually depict the survival rate of GC patients according to important clinical factors, including the risk model.
CANCER CELL INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Shuoshan Wang, Xiansheng Yang, Chang Liu, Jinlun Hu, Mei Yan, Chan Ding, Yue Fu
Summary: This study systematically explored the core genes and crucial pathways in gastric cancer, providing insights into clinical management and individualized treatment.
Article
Oncology
Chen Xiao, Tao Dong, Linhui Yang, Liangzi Jin, Weiguo Lin, Faqin Zhang, Yuanyuan Han, Zhijian Huang
Summary: This study identified immune-related genes, ferroptosis-related genes, and immune-ferroptosis-related differentially expressed genes (IFR-DEGs) in gastric cancer. A 15-gene prognostic feature was constructed, and it was found that the high-risk group had a poorer prognosis. Immune-ferroptosis-related genes showed potential as predictors of immunotherapy response in gastric cancer. The study also predicted the response to small molecule drugs in high and low-risk groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Meng-jie Shan, Ling-bing Meng, Peng Guo, Yuan-meng Zhang, Dexian Kong, Ya-bin Liu
Summary: This study identified CDH3, LEF1, and MMP7 as potential biomarkers for gastric cancer through gene expression analysis, and established a neural network model for early diagnosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shiyu Zhang, Xuelian Xiang, Li Liu, Huiying Yang, Dongliang Cen, Guodu Tang
Summary: This study identified hub genes associated with gastric cancer prognosis and explored potential drugs for treatment by analyzing differentially expressed genes. The findings provide new insights into the molecular mechanisms and treatment options for gastric cancer.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Immunology
Yiping Li, Xiaoqin Li, Yufei Yang, Xuehan Qiao, Qing Tao, Chen Peng, Miao Han, Kebin Dong, Min Xu, Deqiang Wang, Gaohua Han
Summary: This study explores the potential application of genes associated with hereditary metabolic diseases in the diagnosis and treatment of gastric cancer. The findings suggest that these genes could serve as useful markers for diagnosis and prognosis of gastric cancer, as well as predicting patients' response to treatment. Additionally, the study reveals the impact of these genes on immune biomarkers, highlighting their importance in predicting immunotherapy response and survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Hui Sun, Yufeng Wang, Shentao Wang, Yikui Xie, Kun Sun, Shuai Li, Weitong Cui, Kai Wang
Summary: This article investigated the correlation between the expression patterns of collagen family genes and gastric cancer progression using bioinformatics analyses. It was found that many collagen family genes were overexpressed in gastric cancer tissues, especially in the early T stages, highlighting the significance of collagens in tumor enlargement of gastric cancer.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shangshang Hu, Huaifeng Liu, Jinyan Zhang, Shujing Li, Huadong Zhou, Yu Gao
Summary: In this study, the down-regulated expression of miR-30c-5p in gastric cancer tissues and the up-regulation of target genes ADAM12, EDNRA, and CPNE8 were identified. These genes were found to be related to various clinicopathological factors in gastric cancer patients and may play a role in the progression of gastric cancer through cancer-related pathways. They could serve as potential prognostic markers for poor survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Meng Yan, Xiaonian Zhu, Haizhi Qiao, Huiqing Zhang, Wenjie Xie, Jianhui Cai
Summary: CMTM8 protein is downregulated in gastric cancer tissues, and its expression is associated with metastasis and prognosis of gastric cancer patients.
DNA AND CELL BIOLOGY
(2021)
Article
Cell Biology
An Zhi Zhang, Xin Yuan, Wei Hua Liang, Hai Jun Zhang, Ya Li, Yu Fang Xie, Jiang Fen Li, Chen Hao Jiang, Fan Ping Li, Xi Hua Shen, Li Juan Pang, Hong Zou, Wen Hu Zhou, Feng Li, Jian Ming Hu
Summary: Immunotherapy has rapidly developed and become an important method for treating gastric cancer. The presence of tumor infiltrating immune cells and immune-related genes in the tumor microenvironment greatly influence tumor progression and prognosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Hui Li, Jing Guo, Guang Cheng, Yucheng Wei, Shihai Liu, Yaoyue Qi, Gongjun Wang, Ruoxi Xiao, Weiwei Qi, Wensheng Qiu
Summary: This study aimed to identify and verify key SNPs in genes with prognostic value for gastric cancer. Through analysis of SNP data from gastric cancer patients, a network of mutated genes was constructed, leading to the identification of six key genes (TP53, HRAS, BRCA1, PIK3CA, AKT1, and SMARCA4) closely related to patient survival rates. This research provides a foundation for further exploration of gastric cancer molecular pathogenesis and patient prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Hao Wang, Tianyi Fang, Xin Yin, Shenghan Lou, Bangling Han, Jialiang Gao, Yufei Wang, Xibo Wang, Daoxu Zhang, Yimin Wang, Yao Zhang, Yingwei Xue
Summary: This study aimed to investigate the applicability of the Naples prognostic score (NPS) in gastric cancer (GC) and construct a new NPS for individualized prognosis prediction. The results showed that the new NPS can accurately predict the prognosis of GC patients and can be combined with clinicopathological characteristics to construct a nomogram model.