Review
Oncology
Giorgio Bogani, Giuseppe Sarpietro, Gabriella Ferrandina, Valerio Gallotta, Violante Di Donato, Antonino Ditto, Ciro Pinelli, Jvan Casarin, Fabio Ghezzi, Giovanni Scambia, Francesco Raspagliesi
Summary: ERAS is a pathway designed to promote early recovery for patients undergoing major surgery, with three important components: preoperative, intraoperative, postoperative program. Adoption of ERAS can lead to lower complication rates, shorter hospital stays, improved patient outcomes, and reduced overall cost of care.
Article
Clinical Neurology
Bertrand Debono, Thomas W. Wainwright, Michael Y. Wang, Freyr G. Sigmundsson, Michael M. H. Yang, Henriette Smid-Nanninga, Aurelien Bonnal, Jean -Charles Le Huec, William J. Fawcett, Olle Ljungqvist, Guillaume Lonjon, Hans D. de Boer
Summary: ERAS protocols have shown significant improvements in outcomes by optimizing patient care pathways, reducing complications, enhancing patient experience, and shortening hospital stays. A multidisciplinary consensus review on lumbar fusion surgery with ERAS program was conducted, resulting in 28 recommendations covering various aspects of preoperative, intraoperative, and postoperative care.
Article
Immunology
Raffaele Brustia, Antoine Monsel, Stefano Skurzak, Eduardo Schiffer, Francois Martin Carrier, Damiano Patrono, Abdourahamane Kaba, Olivier Detry, Luiz Malbouisson, Wellington Andraus, Franck Vandenbroucke-Menu, Gianni Biancofiore, Toshimi Kaido, Philippe Compagnon, Shinji Uemoto, Gonzalo Rodriguez Laiz, Marieke De Boer, Susan Orloff, Paola Melgar, Carlijn Buis, Miriam Zeillemaker-Hoekstra, Helen Usher, Koen Reyntjens, Emily Baird, Nicolas Demartines, Stephen Wigmore, Olivier Scatton
Summary: This study presents the specific ERAS Society recommendations for liver transplantation (LT) based on the best available evidence and expert consensus. Screening and treatment for malnutrition in patients are recommended. Prophylactic nasogastric intubation and abdominal drainage may be omitted, and early extubation should be considered. Early oral intake, mobilization, and multimodal-balanced analgesia are also recommended.
Review
Public, Environmental & Occupational Health
Aya M. Riad, Aisling Barry, Stephen R. Knight, Carlie J. Arbaugh, Parvez Haque, Thomas G. Weiser, Ewen M. Harrison
Summary: This study reviewed the implementation of ERAS protocols and other perioperative optimization strategies in low- and middle-income countries (LMICs) and evaluated their impact on length of hospital stay (LOS). The findings suggest that perioperative optimization is feasible in LMICs and appears to reduce LOS, despite high levels of between-study heterogeneity.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Oncology
Kimberley L. Kiong, Catherine N. Vu, Christopher M. K. L. Yao, Brittany Kruse, Gang Zheng, Peirong Yu, Randal S. Weber, Carol M. Lewis
Summary: The study demonstrates that ERAS in HNC surgery can lead to improved outcomes and resource utilization, with sustainable results. The findings can be used to optimize ERAS pathways further.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Norbert Hootsmans, Sara Parmiter, Kevin Connors, Shivani B. Badve, Elise Snyder, Justin J. Turcotte, Shyam S. Jayaraman, H. Reza Zahiri
Summary: Perioperative pain management is important for patient satisfaction and safe recovery. Studies show that patients don't require as much opioids as once thought. The use of ERAS pathways can not only enhance patients' perioperative experience, but also reduce opioid prescriptions in the face of the ongoing opioid crisis.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Madeline L. Rasmussen, Steven G. Leeds, Edward P. Whitfield, Bola Aladegbami, Gerald O. Ogola, Marc A. Ward
Summary: This study aimed to develop an ERAS protocol for patients undergoing foregut surgery and determine its impact on outcomes. The results showed that implementing the ERAS protocol led to a 41% decrease in complications and a 33% reduction in length of stay compared to traditional protocols. Completing the ERAS protocol further reduced complications and length of stay compared to patients who deviated from the protocol.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Javier Ripolles-Melchor, Ane Abad-Motos, Andres Zorrilla-Vaca
Summary: This review focuses on the rationale and oncologic outcomes of the application of Enhanced Recovery After Surgery (ERAS) protocols in adult patients undergoing major surgery. It was found that the implementation of ERAS protocols is associated with fewer postoperative complications and decreased return to intended oncologic treatment (RIOT). However, there is limited research on the influence of ERAS application on long-term oncologic outcomes.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Surgery
Basile Pache, David Martin, Valerie Addor, Nicolas Demartines, Martin Hubner
Summary: In Switzerland, most ERAS centers have been validated, but some centers have potential patient selection and missing data issues. Therefore, simplified validation of other centers appears to be mandatory before large-scale use of the EIAS dataset.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
G. Nelson, C. Fotopoulou, J. Taylor, G. Glaser, J. Bakkum-Gamez, L. A. Meyer, R. Stone, G. Mena, K. M. Elias, A. D. Altman, S. P. Bisch, P. T. Ramirez, S. C. Dowdy
Summary: This article presents the updated evidence and recommendations for implementing Enhanced Recovery After Surgery (ERAS) in gynecologic oncology surgery. It focuses on addressing implementation challenges and provides evidence-based guidelines.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Medicine, General & Internal
Bolin Liu, Shujuan Liu, Tao Zheng, Dan Lu, Lei Chen, Tao Ma, Yuan Wang, Guodong Gao, Shiming He
Summary: Population aging poses challenges to healthcare systems. The use of enhanced recovery after surgery (ERAS) protocols has shown benefits for perioperative care in adult patients undergoing elective craniotomy. However, there is a lack of ERAS protocols for geriatric patients over 65 years of age. This paper proposes a novel ERAS protocol for geriatric patients based on successful protocols/guidelines and optimal perioperative care in the literature, as well as the authors' experience. The protocol aims to improve perioperative care and outcomes for geriatric patients undergoing elective craniotomy.
Article
Surgery
Jennifer Y. Lam, Alexandra Howlett, Duncan McLuckie, Lori M. Stephen, Scott D. N. Else, Ashley Jones, Paul Beaudry, Mary E. Brindle
Summary: This study successfully implemented a novel neonatal ERAS(R) guideline using a multidisciplinary team and structured approach, with key elements including champion identification, multidisciplinary stakeholder involvement, consideration of local contexts and insights, patient/family engagement, education, and the creation of an audit system.
Review
Clinical Neurology
Jacob D. Greisman, Zachary T. Olmsted, Patrick J. Crorkin, Colin A. Dallimore, Vadim Zhigin, Artur Shlifer, Anupama D. Bedi, Jane K. Kim, Priscilla Nelson, Heustein L. Sy, Kiran V. Patel, Jason A. Ellis, John Boockvar, David J. Langer, Randy S. D'Amico
Summary: This study combines recent findings to generate evidence-based guidelines for the management of neurosurgical oncology patients and evaluates the ability to coordinate multidisciplinary and patient-centered care.
WORLD NEUROSURGERY
(2022)
Review
Gastroenterology & Hepatology
Salvatore Arena, Donatella Di Fabrizio, Pietro Impellizzeri, Paolo Gandullia, Girolamo Mattioli, Carmelo Romeo
Summary: The ERAS protocol is safe and feasible for pediatric patients undergoing gastrointestinal surgery, effectively reducing hospital stay, improving gastrointestinal function recovery, and decreasing the need for perioperative infusions, postoperative opioids, and costs.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Review
Surgery
Erik Stenberg, Luiz Fernando dos Reis Falcao, Mary O'Kane, Ronald Liem, Dimitri J. Pournaras, Paulina Salminen, Richard D. Urman, Anupama Wadhwa, Ulf O. Gustafsson, Anders Thorell
Summary: This article presents the second updated guideline from the Enhanced Recovery After Surgery (ERAS) Society, providing a consensus and recommendations for optimal perioperative care in bariatric surgery. Through a comprehensive evaluation of literature, evidence-based consensus was achieved.
WORLD JOURNAL OF SURGERY
(2022)
Article
Anesthesiology
Darren Hight, Cornelia Schanderhazi, Markus Huber, Frank Stuber, Heiko A. Kaiser
Summary: With an aging global population, it is important to customize the dosing of anesthetics according to age and their effects on the brain. A recent study observed that the concentration of volatile anesthetics during general surgery decreases by around 3% per age-decade, which is less than the expected decrease of 6% based on age-adjusted values. Paradoxically, despite the excessive dosing, the Bispectral index (BIS) values also increased. The aim of this study was to investigate this paradox of age using the Narcotrend depth of anesthesia monitor.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Anesthesiology
Sven Petersen, Markus Huber, Federico Storni, Gero Puhl, Alice Deder, Axel Prause, Joerg C. Schefold, Dietrich Doll, Patrick Schober, Markus M. Luedi
Summary: This study aimed to predict survival outcomes in peritonitis patients treated with open abdomen surgery using a multidomain prediction model. The results indicated that the surgical predictor skin closure, along with the physiological predictors SAPS-II and MPI, were key factors in predicting survival. The integrative prediction model outperformed individual predictors in predicting survival outcomes.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2022)
Article
Anesthesiology
Thomas Riva, Robert Greif, Heiko Kaiser, Thomas Riedel, Markus Huber, Lorenz Theiler, Sabine Nabecker
Summary: This study investigated the effects of different flow rates of humidified 100% oxygen on the increase of arterial partial pressure of carbon dioxide. The results showed that different flow rates resulted in comparable increases in arterial partial pressure of carbon dioxide, suggesting no additional ventilatory effect of high-flow nasal oxygenation.
Article
Pediatrics
Thomas Riva, Thomas Engelhardt, Reto Basciani, Rachele Bonfiglio, Evelien Cools, Alexander Fuchs, Annery G. Garcia-Marcinkiewicz, Robert Greif, Walid Habre, Markus Huber, Maria -Alexandra Petre, Britta S. von Ungern-Sternberg, David Sommerfield, Lorenz Theiler, Nicola Disma, OPTIMISE Collaboration
Summary: Direct laryngoscopy and video laryngoscopy with supplemental oxygen were compared in neonates and infants undergoing tracheal intubation. The study found that video laryngoscopy with standard blades and supplemental oxygen increased the success rate of first-attempt tracheal intubation compared to direct laryngoscopy. The incidence of adverse events was similar between the two groups.
LANCET CHILD & ADOLESCENT HEALTH
(2023)
Article
Anesthesiology
Eloy S. Fehrlin, Darren Hight, Heiko A. Kaiser, Markus M. Luedi, Markus Huber, Frederic Zubler, Friedrich Lersch
Summary: A new index called FO-RPAB was proposed to monitor the ratio of alpha and beta activity between the frontal and occipital regions during general anesthesia. FO-RPAB was found to serve as a marker of unconsciousness and was not affected by additional administration of ketamine for analgesia.
ANESTHESIA AND ANALGESIA
(2023)
Article
Medical Informatics
Markus Huber, Patrick Schober, Sven Petersen, Markus M. M. Luedi
Summary: Prediction models have become increasingly important in perioperative systems approaches, particularly in complex patients with open abdomen treatment for peritonitis. Combining predictors from multiple medical domains enhances the prediction capabilities compared to single-domain models. However, the clinical utility of these prediction models needs further investigation.
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2023)
Letter
Anesthesiology
Christian M. Beilstein, Markus Huber, Dominique Engel, Patrick Y. Wuethrich
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Emergency Medicine
Alexander Fuchs, Markus Huber, Thomas Riva, Stefan Becker, Roland Albrecht, Robert Greif, Urs Pietsch
Summary: For helicopter emergency service systems, factors such as helicopter hoist operations, resuscitation, airway management, critical interventions, remote location, night-time, and paediatric patients are associated with longer on-scene times. Compared to adult patients, paediatric patients had longer on-scene times. Improving individual interventions or performing them in parallel may reduce on-scene time.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2023)
Article
Medicine, General & Internal
Alexander Fuchs, Lea Franzmeier, Marie Cheseaux-Carrupt, Martina Kaempfer, Nicola Disma, Urs Pietsch, Markus Huber, Thomas Riva, Robert Greif
Summary: This retrospective observational study evaluated anesthesia procedures from 2015 to 2021 and found that intraoperative cardiac arrest is rare but more common in older patients, those with ASA physical status ≥IV, cardiac and vascular surgery, and emergency procedures. Most patients had pulseless electrical activity as the initial rhythm. With immediate treatment, most patients can achieve return of spontaneous circulation and survive after 30 days, with favorable neurological outcomes for the majority.
FRONTIERS IN MEDICINE
(2023)
Article
Multidisciplinary Sciences
Nora Mihalek, Dragana Radovanovic, Otto Barak, Petar Colovic, Markus Huber, Gabor Erdoes
Summary: This study aimed to investigate the survival benefit of convalescent plasma therapy in COVID-19 patients. The results showed no statistical evidence of the benefit of convalescent plasma therapy on all-cause mortality. Further studies are needed to determine in which patients this therapy may lead to a reduction in mortality.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Markus Huber, Marc A. Furrer, Francois Jardot, Dominique Engel, Christian M. Beilstein, Fiona C. Burkhard, Patrick Y. Wuethrich
Summary: The use of norepinephrine and intraoperative fluid administration have been found to increase the risk of acute kidney injury (AKI) after cystectomy. A study on 1488 patients showed that the overall incidence of AKI was 21.6%, and it increased by 0.6% per year since 2000. Decreased intraoperative fluid balance combined with increased norepinephrine administration were associated with an increased risk of AKI, though other factors may also contribute to the observed increase in AKI incidence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Katharina Staufer, Heidemarie Huber, Jasmin Zessner-Spitzenberg, Rudolf Stauber, Armin Finkenstedt, Heike Bantel, Thomas S. Weiss, Markus Huber, Rudolf Markus, Patrick Starlinger, Thomas Gruenberger, Thomas Reiberger, Susanne Sebens, Gail McIntyre, Ray Tabibiazar, Amato Giaccia, Heinz Zoller, Michael Trauner, Wolfgang Mikulits
Summary: The expression of Axl and sAxl is increased in liver fibrosis, cirrhosis, and HCC. Gas6/alb ratio shows high diagnostic accuracy for the detection of fibrosis and cirrhosis, and predicts severity of liver disease including CSPH. However, it fails to discriminate between HCC in cirrhosis versus cirrhosis only.
CELL DEATH DISCOVERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jan-Oliver Friess, Maurus Beeler, Murat Yildiz, Dominik P. Guensch, Anja Levis, Daniel Gerber, Jakob Wollborn, Hansjoerg Jenni, Markus Huber, Florian Schoenhoff, Gabor Erdoes
Summary: The aim of this study was to determine the cerebral perfusion flow rate required to achieve the preoperative awake baseline cerebral oxygen saturation. The results showed that a flow rate of 8 ml/kg/min during selective antegrade cerebral perfusion is more likely to achieve the baseline cerebral saturation value.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Anesthesiology
Thomas Riva, Simon Goerge, Alexander Fuchs, Robert Greif, Markus Huber, Andrea C. Lusardi, Thomas Riedel, Francis F. Ulmer, Nicola Disma
Summary: This study aims to investigate the equivalence between rapid-sequence tracheotomy and scalpel-bougie tracheotomy in establishing tracheal access using rabbit cadavers. The primary outcome is the duration until successful tracheal tube placement. Secondary outcomes include success rate, structural injuries, and participant self-evaluation.
PEDIATRIC ANESTHESIA
(2023)
