Review
Biochemistry & Molecular Biology
Xueyan Yang, Jun Feng, Wei Liang, Zijing Zhu, Zhaowei Chen, Jijia Hu, Dingping Yang, Guohua Ding
Summary: SIRT6 is a crucial NAD(+) dependent deacetylase primarily located in the nucleus, regulating various physiological activities such as DNA repair, energy metabolism, oxidative stress, inflammation, and fibrosis. In the context of kidney disease, SIRT6 plays a vital role in maintaining cellular homeostasis and delaying disease progression.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Cem Tanriover, Sidar Copur, Duygu Ucku, Ahmet B. Cakir, Nuri B. Hasbal, Maria Jose Soler, Mehmet Kanbay
Summary: Mitochondrial dysfunction plays a significant role in the pathogenesis of kidney diseases and potential therapeutic interventions targeting mitochondria are under investigation. Key mechanisms underlying mitochondrial dysfunction in kidney diseases include alterations in mitochondrial biogenesis, imbalance in fusion and fission processes leading to fragmentation, oxidative stress, apoptosis caused by release of cytochrome c and mitochondrial DNA, mitophagy, and defects in energy metabolism. Current strategies focus on improving kidney function by targeting mitochondria using agents that activate biogenesis, inhibit fission, act as antioxidants, inhibit mitochondrial permeability transition pore (mPTP), enhance mitophagy, and protect cardiolipin. Glucose-lowering drugs such as glucagon-like peptide-1 receptor agonists (GLP-1-RA) and sodium glucose co-transporter-2 (SGLT-2) inhibitors also have effects on these mechanisms. This review discusses the role of mitochondrial dysfunction in kidney diseases, current mitochondria-targeting treatment options, and the future possibilities of mitochondria in kidney pathology.
Review
Immunology
Sarah Cormican, Matthew D. Griffin
Summary: Innate immune cells play a key role in kidney inflammation and fibrosis, with the CX3CL1-CX3CR1 signaling pathway being closely linked to acute and chronic kidney diseases. Targeting this pathway may offer potential benefits for patients with CKD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mengdi Wang, Yanyu Pang, Yifan Guo, Lei Tian, Yufei Liu, Cun Shen, Mengchao Liu, Yuan Meng, Zhen Cai, Yuefen Wang, Wenjing Zhao
Summary: Diabetic kidney disease (DKD) is a common complication of diabetes mellitus, but its pathogenesis is poorly understood. Metabolic reprogramming plays a critical role in the development of DKD, and understanding its role may lead to new therapeutic approaches.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shilu Luo, Ming Yang, Hao Zhao, Yachun Han, Na Jiang, Jinfei Yang, Wei Chen, Chenrui Li, Yan Liu, Chanyue Zhao, Lin Sun
Summary: Caveolin-1 (Cav-1) plays a crucial role in regulating cellular endocytosis, stress responses, and signal transduction. It is involved in mediating the endocytosis of albumin, cholesterol, and glucose, participating in cellular metabolic reprogramming, and contributing to the progression of kidney disease. Cav-1 also serves as a potential therapeutic target for the treatment of kidney disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yunfeng Pan, Jia Liu, Jiahui Ren, Yun Luo, Xiaobo Sun
Summary: This study reviews the regulatory effects of Epac on various vascular diseases, including cardiovascular disease, cerebrovascular disease, and cancer. It suggests that Epac could serve as a promising therapeutic target for the treatment of vascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kranti A. Mapuskar, Gabriela Vasquez-Martinez, Gabriel Mayoral-Andrade, Ann Tomanek-Chalkley, Diana Zepeda-Orozco, Bryan G. Allen
Summary: Chronic kidney disease (CKD) increases the risk of end-stage renal disease (ESRD) and its associated morbidity and mortality. CKD can lead to metabolic perturbations and oxidative stress, resulting in increased production of reactive oxygen species (ROS) in the kidneys. Mitochondrial oxidative metabolism plays a role in the pathology of CKD, and targeting mitochondria may be a potential treatment approach to delay CKD progression.
Review
Cell Biology
Tong Li, Guangjuan Zheng, Ben Li, Lipeng Tang
Summary: Pyroptosis is a form of programmed cell death characterized by the formation of inflammatory pores, cellular lysis, and release of pro-inflammatory cytokines, associated with intracellular pathogens-induced infection. However, it is now understood that pyroptosis also plays a role in sterile inflammation. Targeting the pyroptotic signaling pathway with specific inhibitors may offer a promising approach for the treatment of noninfective inflammatory disorders.
CELL PROLIFERATION
(2021)
Article
Genetics & Heredity
Annika Heinz, Judith Schilling, Willeke van Roon-Mom, Sybille Krauss
Summary: Huntington's disease is caused by a mutation of the HTT gene, with pathological changes most prominent in the central nervous system. Recent studies suggest that besides the mutant protein, the mutant RNA transcript also plays a role in cellular dysfunction, making blocking the interaction between MID1 and mutant HTT mRNA a promising therapeutic approach to counteract the translation of mutant HTT.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Jingzhi Leng, Chuanzhi Wang, Zhide Liang, Fanghui Qiu, Shuangshuang Zhang, Yuan Yang
Summary: YAP is a downstream effector of the Hippo signaling pathway and plays a crucial role in cardiomyocyte survival. The Hippo/YAP axis potentially contributes to the development of cardiac, vascular, and renal injuries, and it is a key mediator of fibrosis in the infarcted heart.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Immunology
Szymon Hryhorowicz, Marta Kaczmarek-Rys, Aleksandra Zielinska, Rodney J. Scott, Ryszard Slomski, Andrzej Plawski
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease and ulcerative colitis. The endocannabinoid system (ECS) plays a crucial role in modulating intestinal inflammation, suggesting potential therapeutic benefits.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Feng Tian, Hui Chen, Jianmin Zhang, Wei He
Summary: Chronic kidney disease (CKD), a complication of autoimmune diseases, is challenging to cure and has significant health and economic implications. By understanding the metabolic changes in immune cells and regulating immune cell metabolism, new strategies for treating and preventing kidney damage caused by autoimmune diseases are being explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Amrutha Menon, Noraini Abd-Aziz, Kanwal Khalid, Chit Laa Poh, Rakesh Naidu
Summary: This review focuses on the role of miRNA in cancer, therapeutic approaches with miRNAs, and effective delivery into the system. Patents and ongoing clinical trials for miRNA therapy are also summarized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ioan-Andrei Iliuta, Xuewen Song, Lauren Pickel, Amirreza Haghighi, Ravi Retnakaran, James Scholey, Hoon-Ki Sung, Gregory R. Steinberg, York Pei
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is the most common Mendelian kidney disease, and overweight/obesity is an independent risk factor for disease progression. Studies have found shared pathobiology between ADPKD and overweight/obesity, and pharmacological activation of AMPK provides a promising approach for ADPKD treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Immunology
Hai Zhao, Shuangshuang Song, Junwei Ma, Zhiyong Yan, Hongwei Xie, Ying Feng, Shusheng Che
Summary: CD47 is a protein that is ubiquitously expressed on the surface of cells and plays a critical role in self-recognition. It modulates cellular phagocytosis, determines the lifespan of erythrocytes, regulates immune cell activation, and manipulates synaptic pruning during neuronal development. Recently, CD47 has been identified as a novel target for cancer immunotherapy. This review discusses the diverse functions of CD47, its role in immune system homeostasis, and its potential therapeutic roles against cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
