Article
Pharmacology & Pharmacy
Amayelle Rey, Valerie Gras, Julien Moragny, Gabriel Choukroun, Kamel Masmoudi, Sophie Liabeuf
Summary: Drug-induced acute kidney injury (AKI) can occur both in primary care and hospital settings. The prevalence of drug-induced AKI is relatively high and may be underestimated. During the study period, a total of 1,557 AKI episodes were recorded, with approximately 38.1% being categorized as drug-induced AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Urology & Nephrology
Natalie Ebert, Alice Schneider, Doerte Huscher, Nina Mielke, Yanina Balabanova, Gunnar Brobert, Carla Lakenbrink, Martin Kuhlmann, Anne-Katrin Fietz, Markus van der Giet, Volker Wenning, Elke Schaeffner
Summary: This study investigated the incidence rates of hospital-acquired AKI and trajectories of kidney function before hospitalization in older adults. The results showed that AKI is common in individuals aged 70+ and the incidence rates increase with age. Furthermore, the decline in kidney function was faster in patients with AKI compared to those without AKI years before hospitalization.
Article
Urology & Nephrology
Soraya Arzhan, Maria-Eleni Roumelioti, Igor Litvinovich, Cristian G. Bologa, Mark L. Unruh
Summary: Hospital-acquired hypernatremia is associated with in-hospital mortality and discharge to hospice or to nursing facilities in all stages of CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Changwei Wu, Yun Zhang, Sheng Nie, Daqing Hong, Jiajing Zhu, Zhi Chen, Bicheng Liu, Huafeng Liu, Qiongqiong Yang, Hua Li, Gang Xu, Jianping Weng, Yaozhong Kong, Qijun Wan, Yan Zha, Chunbo Chen, Hong Xu, Ying Hu, Yongjun Shi, Yilun Zhou, Guobin Su, Ying Tang, Mengchun Gong, Li Wang, Fanfan Hou, Yongguo Liu, Guisen Li
Summary: This study developed a deep learning model to predict the risk of in-hospital death and dialysis for patients with acute kidney injury (AKI) during hospitalization. The model showed consistent predictive performance in both internal and external validation cohorts.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Henna Duong, Wubshet Tesfaye, Connie Van, Kamal Sud, Ronald L. Castelino
Summary: The aim of this study was to evaluate the use of high-risk medications in patients with community-acquired acute kidney injury (CA-AKI) and to assess the differences in CA-AKI characteristics and outcomes based on medication use. The study found that a high proportion of CA-AKI patients were taking SADMANS medications and that patients on these medications had more comorbidities and a higher medication burden. However, there were no significant differences in AKI severity or outcomes between patients on SADMANS medications and those not on them. The study suggests a potential need to consider withholding these medications during acute illness to prevent CA-AKI hospitalizations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Chen Liu, Suying Yan, Yuqin Wang, Jinwei Wang, Xiujuan Fu, Hongtao Song, Rongsheng Tong, Mei Dong, Weihong Ge, Jiawei Wang, Hui Yang, Changlian Wang, Peiyuan Xia, Limei Zhao, Sijing Shen, Juan Xie, Yangui Xu, Peizhi Ma, Hongjian Li, Shegui Lu, Yufeng Ding, Ling Jiang, Yang Lin, Maoyi Wang, Feng Qiu, Wanyu Feng, Li Yang
Summary: This study investigated the disease burden, related drugs, and risk factors of D-AKI in China, revealing a substantial medical burden associated with D-AKI, with a high mortality rate and low recovery rate among patients. Efforts should be made to manage nephrotoxic drugs and improve prevention, diagnosis, and treatment of D-AKI.
Article
Medicine, General & Internal
Justin Y. Lu, Ioannis Babatsikos, Molly C. Fisher, Wei Hou, Tim Q. Duong
Summary: Acute kidney injury (AKI) is associated with high mortality in COVID-19 patients. Patients with hospital-acquired AKI (HA-AKI) and community-acquired AKI (CA-AKI) in COVID-19 differ in clinical characteristics and outcomes, with older patients and more comorbidities in HA-AKI cases compared to CA-AKI cases.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Rubina Naqvi
Summary: Epidemiological studies on community-acquired AKI in Pakistan are limited, and this retrospective study from 1990 to 2014 revealed different trends among medical, obstetrical, and surgical AKI patients. Older age, thrombocytopenia, deranged liver function, and multiorgan failure were predictors of higher mortality across all groups.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Immunology
Orestis Katsoulis, Athina Georgiadou, Aubrey J. Cunnington
Summary: Acute kidney injury is a common complication of severe malaria and an independent risk factor for death. Different aspects of malaria pathology interact to amplify the damaging effects of the host inflammatory response on the kidneys.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Annmarie I. Mede, Ginger L. Milne, Dawei Wei, Derek K. Smith, Loren E. Smith
Summary: Acute kidney injury (AKI) is a serious complication after vascular surgery and impaired NAD+ synthesis may contribute to its development in these patients. Elevated postoperative quinolinate to tryptophan ratios were associated with AKI, and higher preoperative quinolinate concentrations and postoperative ratios were associated with greater postoperative creatinine increases.
Article
Chemistry, Multidisciplinary
Jiajia Li, Qijia Duan, Xiaona Wei, Jianping Wu, Qiongqiong Yang
Summary: This study developed a nanoparticle for targeted delivery of rosmarinic acid (RA) in the treatment of acute kidney injury (AKI). The nanoparticle showed excellent antioxidative and antiapoptotic effects, improved renal function, and repaired damaged renal tissue in vivo.
Article
Endocrinology & Metabolism
L. Xing, S-Y Liu, Q-M Cao, X. Li, H-D Mao, J-B Zhao, L-J Duan, Q. Song
Summary: This study aimed to analyze factors related to acute kidney injury (AKI) in patients with heatstroke. Male patients were more prone to AKI, and those with AKI had higher core body temperature and lower mean arterial pressure. They also required more mechanical ventilation, renal replacement therapy, and blood transfusion compared to non-AKI patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Review
Biochemistry & Molecular Biology
Li-Fang Chou, Huang-Yu Yang, Cheng-Chieh Hung, Ya-Chung Tian, Shen-Hsing Hsu, Chih-Wei Yang
Summary: Leptospirosis is a neglected bacterial disease caused by leptospiral infection, which has a high mortality risk. It has been found that leptospiral infections, including acute, chronic, and asymptomatic infections, are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires infiltrate kidney cells and survive in the kidney by evading the immune system. The binding of bacterial outer membrane protein LipL32 to toll-like receptor-2 in renal tubular epithelial cells (TECs) is the most well-known pathogenic mechanism of renal tubular damage caused by leptospiral infection.
BIOMEDICAL JOURNAL
(2023)
Article
Infectious Diseases
Justin Y. Lu, Wei Hou, Tim Q. Duong
Summary: The study investigated the temporal characteristics of clinical variables in COVID-19 patients with hospital-acquired AKI and longitudinally predicted AKI onset. The results showed that AKI developed on average 3.3 days after hospitalization, with certain clinical variables such as creatinine, procalcitonin, and white blood cells being able to predict AKI onset. This insight may lead to earlier recognition of AKI and improved clinical outcomes.
Review
Immunology
Yali Wang, Yan Zhang, Songtao Shou, Heng Jin
Summary: Acute kidney injury (AKI) is a common kidney disease with a high mortality rate. It can be caused by various factors and has the potential to progress to chronic kidney disease. IL-17, a pro-inflammatory cytokine, is linked to AKI and can be targeted for its prevention and treatment. This review provides an overview of IL-17's structure, signaling pathways, biological functions, and its role in AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)