Targeting the up-regulated CNOT3 reverses therapeutic resistance and metastatic progression of EGFR-mutant non-small cell lung cancer

Cancer statistics, 2022

(2022) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

HER2 Amplification in Advanced NSCLC Patients After Progression on EGFR-TKI and Clinical Response to EGFR-TKI Plus Pyrotinib Combination Therapy

(2021) Jiadi Gan et al.   OncoTargets and Therapy

Molecular Mechanism of EGFR-TKI Resistance in EGFR-Mutated Non-Small Cell Lung Cancer: Application to Biological Diagnostic and Monitoring

(2021) Damien Reita et al.   Cancers

The Ccr4-Not complex monitors the translating ribosome for codon optimality

(2020) Robert Buschauer et al.   SCIENCE

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

(2020) Michael A. Gillette et al.   CELL

The next tier of EGFR resistance mutations in lung cancer

(2020) Hannah L. Tumbrink et al.   ONCOGENE

PI3K-AKT-mTOR pathway alterations in advanced NSCLC patients after progression on EGFR-TKI and clinical response to EGFR-TKI plus everolimus combination therapy

(2020) Wenfeng Fang et al.   Translational Lung Cancer Research

Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation

(2020) Dina Mostafa et al.   Communications Biology

CNOT3 contributes to cisplatin resistance in lung cancer through inhibiting RIPK3 expression

(2019) Lin Jing et al.   APOPTOSIS

Resistance mechanisms to osimertinib in EGFR-mutated non-small cell lung cancer

(2019) Alessandro Leonetti et al.   BRITISH JOURNAL OF CANCER

Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors

(2018) D Westover et al.   ANNALS OF ONCOLOGY

Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR

(2018) Shuyan Meng et al.   LUNG CANCER

EGFR-TKIs resistance via EGFR-independent signaling pathways

(2018) Qian Liu et al.   Molecular Cancer

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

(2018) Tomokazu Yamaguchi et al.   Science Signaling

The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function

(2018) Tomokazu Yamaguchi et al.   Science Signaling

Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?

(2018) Gonzalo Recondo et al.   Nature Reviews Clinical Oncology

CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development

(2018) Yo-Taro Shirai et al.   ONCOGENE

Adipocyte-specific disruption of mouseCnot3causes lipodystrophy

(2017) Xue Li et al.   FEBS LETTERS

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype

(2016) Paloma Cejas et al.   CANCER RESEARCH

Large-scale screening for somatic mutations in lung cancer

(2016) Rafael Rosell et al.   LANCET

Post-transcriptional Control of Tumor Cell Autonomous Metastatic Potential by CCR4-NOT Deadenylase CNOT7

(2016) Farhoud Faraji et al.   PLoS Genetics

The Ccr4-Not complex is a key regulator of eukaryotic gene expression

(2016) Martine A. Collart   Wiley Interdisciplinary Reviews-RNA

CNOT3 contributes to early B cell development by controllingIghrearrangement andp53mRNA stability

(2015) Takeshi Inoue et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Implications of mitogen-activated protein kinase signaling in glioma

(2015) Vimal Pandey et al.   JOURNAL OF NEUROSCIENCE RESEARCH

CNOT3 suppression promotes necroptosis by stabilizing mRNAs for cell death-inducing proteins

(2015) Toru Suzuki et al.   Scientific Reports

Acquired resistance to TKIs in solid tumours: learning from lung cancer

(2014) D. Ross Camidge et al.   Nature Reviews Clinical Oncology

The Not5 Subunit of the Ccr4-Not Complex Connects Transcription and Translation

(2014) Zoltan Villanyi et al.   PLoS Genetics

Multifunctional roles of the mammalian CCR4–NOT complex in physiological phenomena

(2014) Yo-Taro Shirai et al.   Frontiers in Genetics

An integrated systems genetics screen reveals the transcriptional structure of inherited predisposition to metastatic disease

(2013) F. Faraji et al.   GENOME RESEARCH

Non-Small Cell Lung Cancer: Epidemiology, Risk Factors, Treatment, and Survivorship

(2012) Julian R. Molina et al.   MAYO CLINIC PROCEEDINGS

Presence of Not5 and ubiquitinated Rps7A in polysome fractions depends upon the Not4 E3 ligase

(2012) Olesya O. Panasenko et al.   MOLECULAR MICROBIOLOGY

Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors

(2011) L. V. Sequist et al.   Science Translational Medicine

mTOR—What Does It Do?

(2008) M.N. Hall   TRANSPLANTATION PROCEEDINGS