Article
Cell Biology
Philma Glora Muthuraj, Prakash K. Sahoo, Madison Kraus, Taylor Bruett, Arun S. Annamalai, Aryamav Pattnaik, Asit K. Pattnaik, Siddappa N. Byrareddy, Sathish Kumar Natarajan
Summary: ZIKV infection induces apoptosis in placental trophoblasts, possibly through triggering endoplasmic reticulum stress and activating the JNK pathway, while inhibition of JNK significantly prevents ZIKV-induced apoptosis.
CELL DEATH DISCOVERY
(2021)
Article
Biochemistry & Molecular Biology
Livia Rosa-Fernandes, Carla Bandeira, Shahab Zaki Pour, Viviane de Fatima Benedetti, Daniel Ferreira, Aline R. Lorenzon, Jusciele B. Moreli, Claudio Romero Farias Marinho, Martin R. Larsen, Paolo Zanotto, Giuseppe Palmisano, Estela Bevilacqua
Summary: The study utilized quantitative proteomics analysis to investigate the impact of ZIKV infection on placental cells, revealing altered levels of proteins involved in cell proliferation, apoptosis, and inflammatory processes. The findings suggest that antibody-opsonized ZIKV particles may play a pivotal role in determining infection outcomes and the role of mixed infections, providing valuable insights for infection control strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Multidisciplinary Sciences
Dawn M. Dudley, Michelle R. Koenig, Laurel M. Stewart, Matthew R. Semler, Christina M. Newman, Phoenix M. Shepherd, Keisuke Yamamoto, Meghan E. Breitbach, Michele Schotzko, Sarah Kohn, Kathleen M. Antony, Hongyu Qiu, Priyadarshini Tunga, Deborah M. Anderson, Wendi Guo, Maria Dennis, Tulika Singh, Sierra Rybarczyk, Andrea M. Weiler, Elaina Razo, Ann Mitzey, Xiankun Zeng, Jens C. Eickhoff, Emma L. Mohr, Heather A. Simmons, Michael K. Fritsch, Andres Mejia, Matthew T. Aliota, Thomas C. Friedrich, Thaddeus G. Golos, Shantha Kodihalli, Sallie R. Permar, David H. O'Connor
Summary: Currently, there are no approved drugs to treat Zika virus infection during pregnancy. However, administering ZIKV-specific human immune globulin has shown promise in controlling the infection and preventing congenital Zika syndrome (CZS) by generating antibodies. Further studies are needed to fully assess the impact of this treatment.
Article
Medicine, General & Internal
Enny S. Paixao, Luciana L. Cardim, Maria C. N. Costa, Elizabeth B. Brickley, Rita C. O. de Carvalho-Sauer, Eduardo H. Carmo, Roberto F. S. Andrade, Moreno S. Rodrigues, Rafael V. Veiga, Larissa C. Costa, Cynthia A. Moore, Giovanny V. A. Franca, Liam Smeeth, Laura C. Rodrigues, Mauricio L. Barreto, Maria G. Teixeira
Summary: A population-based cohort study in Brazil found that infants with congenital Zika syndrome had significantly higher mortality rates during the first three years of life compared to those without the syndrome. The risk of death among infants with congenital Zika syndrome remained high regardless of gestational age or birth weight.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Romain Marlin, Delphine Desjardins, Vanessa Contreras, Guillaume Lingas, Caroline Solas, Pierre Roques, Thibaut Naninck, Quentin Pascal, Sylvie Behillil, Pauline Maisonnasse, Julien Lemaitre, Nidhal Kahlaoui, Benoit Delache, Andres Pizzorno, Antoine Nougairede, Camille Ludot, Olivier Terrier, Nathalie Dereuddre-Bosquet, Francis Relouzat, Catherine Chapon, Raphael Ho Tsong Fang, Sylvie van der Werf, Manuel Rosa Calatrava, Denis Malvy, Xavier de Lamballerie, Jeremie Guedj, Roger Le Grand
Summary: Repurposed antiviral drugs are valuable resources for outbreak defense, but rigorous evaluation in large animal models is crucial for successful clinical implementation. This study evaluates the antiviral activity of favipiravir against Zika virus and SARS-CoV-2 in cynomolgus macaques, highlighting its potential for clinical investigations against Zika virus but advising against its use for SARS-CoV-2 infection.
NATURE COMMUNICATIONS
(2022)
Article
Virology
Kritika Kedarinath, Candace R. Fox, Erin Crowgey, Joseph Mazar, Peter Phelan, Tamarah J. Westmoreland, Kenneth A. Alexander, Griffith D. Parks
Summary: The study found that CD24 expression in neuroblastoma cells suppresses intracellular antiviral pathways, suggesting that CD24 may represent a novel biomarker in cancer cells for susceptibility to oncolytic viruses.
Article
Biology
Zikai Zhao, Qi Li, Usama Ashraf, Mengjie Yang, Wenjing Zhu, Jun Gu, Zheng Chen, Changqin Gu, Youhui Si, Shengbo Cao, Jing Ye, Jan E. Carette
Summary: The study reveals a novel mechanism of ZIKV-induced adverse fetal outcomes by causing placental cell pyroptosis.
Article
Biochemistry & Molecular Biology
Philma Glora Muthuraj, Aryamav Pattnaik, Prakash K. Sahoo, Md Torikul Islam, Asit K. Pattnaik, Siddappa N. Byrareddy, Corrine Hanson, Ann Anderson Berry, Stephen D. Kachman, Sathish Kumar Natarajan
Summary: Studies have shown that omega-7 monounsaturated fatty acid protects placental trophoblasts against Zika virus-induced endoplasmic reticulum stress and apoptosis.
Article
Microbiology
Mercedes Viettri, Gerson Caraballo, Maria Elena Sanchez, Aurora Espejel-Nunez, Abigail Betanzos, Vianney Ortiz-Navarrete, Guadalupe Estrada-Gutierrez, Porfirio Nava, Juan E. Ludert
Summary: This study compared the growth and dissemination of Zika virus (ZIKV) with dengue virus (DENV) and yellow fever virus (YFV-17D) in cells. The results showed that ZIKV has a greater ability to infect cells and inhibits the immune and chemical responses of cells.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Hao Wu, Xing-Yao Huang, Meng-Xu Sun, Yue Wang, Hang-Yu Zhou, Ying Tian, Beijia He, Kai Li, De-Yu Li, Ai-Ping Wu, Hongmei Wang, Cheng-Feng Qin
Summary: This study investigated the infectivity and pathological effects of Zika virus (ZIKV) on placental trophoblast progenitor cells in early human embryos. The researchers found that human trophoblast stem cells (hTSCs) were susceptible to ZIKV infection, but resistance increased with cell differentiation. ZIKV infection disrupted the structure of mature hTSC-organoids and inhibited syncytialization. The researchers also suggested that ZIKV infection may lead to a preeclampsia phenotype.
NATURE COMMUNICATIONS
(2023)
Article
Infectious Diseases
Breno Lima de Almeida, Marta Giovanetti, Joao Vitor Oliveira, Tereza Cristina Xavier Carvalho, Eduardo Manoel Figueiredo, Rosana Pellegrini, Juan Ignacio Calcagno, Marcia Weber Carneiro, Juliana M. G. C. de Oliveira, Adriana Virginia Barros Faical, Iluska Andrade Agra, Cristina Salles, Emilia Katiane Embirucu de Araujo Leao, Rita Lucena, Angelina X. Acosta, Luiz Carlos Junior Alcantara, Isadora Cristina de Siqueira
Summary: This study investigated fourteen asymptomatic normocephalic newborns with confirmed congenital Zika infection. All newborns tested positive for Zika virus on reverse transcriptase polymerase chain reaction. Phylogenetic analysis of one child's ZIKV-specific NS5 gene fragment sequencing revealed that the isolated strain belonged to the Asian genotype and clustered closely with sequences previously isolated in the northeast and northern regions of Brazil.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Chemistry, Multidisciplinary
Brindha Jayachandran, Kaushik Chanda, Musuvathi Motilal Balamurali
Summary: Scientists are now turning their attention to neglected diseases such as dengue and Zika in light of the emergence of more virulent SARS virus, making progress in researching their pathogenicity, diagnostics, and treatment strategies.
Article
Biochemistry & Molecular Biology
Shulong Zu, Chunfeng Li, Lili Li, Yong-Qiang Deng, Xiang Chen, Dan Luo, Qing Ye, Yi-Jiao Huang, Xiao-Feng Li, Rong-Rong Zhang, Nina Sun, Xianqi Zhang, Saba R. Aliyari, Karin Nielsen-Saines, Jae U. Jung, Heng Yang, Cheng-Feng Qin, Genhong Cheng
Summary: TRIM22, an ISG, plays a crucial role in host defense against flaviviruses by binding and degrading NS1 and NS3 proteins.
CELL AND BIOSCIENCE
(2022)
Article
Biochemical Research Methods
Katharine Best, Dan H. Barouch, Jeremie Guedj, Ruy M. Ribeiro, Alan S. Perelson
Summary: This study used mathematical modeling to analyze the impact of varying doses of Zika virus on model parameters and developed a novel infection model incorporating viral interference with the innate immune response. The research found that larger inoculum doses lead to faster infection dynamics, but approximately the same total amount of viral production.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Microbiology
Lei Yu, Xinglong Liu, Xianmiao Ye, Wan Su, Xiaoyan Zhang, Weiqi Deng, Jia Luo, Mengrong Xiang, Wenjing Guo, Shengnan Zhang, Wei Xu, Qihong Yan, Qian Wang, Yilan Cui, Caixia Wu, Xuefeng Niu, Fuchun Zhang, Chunliang Lei, Linbing Qu, Ling Chen, Liqiang Feng
Summary: The study found that human MAbs 3G2 and 4B8 targeted on NS1 can inhibit ZIKV infection, not only through ADC triggering antibody-dependent cell-mediated cytotoxicity, but possibly also through Fcγ receptor-independent mechanisms at postentry stages. In contrast to 3G2 and 4B8, 4F10 mainly provides protective effects through Fc-mediated effector function, and disrupting this mechanism would eliminate protective effects.
