Article
Gastroenterology & Hepatology
Juan M. Pericas, Frank Tacke, Quentin M. Anstee, Nicholas A. Di Prospero, Mette Skalshoj Kjaer, Peter Mesenbrink, Franz Koenig, Joan Genesca, Vlad Ratziu, EU-PEARL NASH Invest
Summary: Non-alcoholic fatty liver disease affects 25% of the population and non-alcoholic steatohepatitis (NASH) is a progressive form of the disease with severe complications. The traditional clinical trials in NASH pose challenges for drug development, and platform trials, utilizing a master protocol and adaptive randomization, offer an alternative approach to evaluate multiple investigational medicinal products concurrently or sequentially.
JOURNAL OF HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Rana Zareef, Marwa Diab, Tala Al Saleh, Adham Makarem, Nour K. Younis, Fadi Bitar, Mariam Arabi
Summary: The COVID-19 pandemic has had a significant impact on medical and economic sectors. Severe cases of the disease can lead to life-threatening complications. Aspirin, with its anti-inflammatory and anti-platelet effects, has been considered as a potential therapeutic agent, but more clinical evidence is needed.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Food Science & Technology
Sandra Lamas, Nuno Rodrigues, Antonio M. Peres, Jose Alberto Pereira
Summary: Flavouring and fortifying virgin olive oils is a growing commercial trend that enhances the sensory profile and chemical composition of the oils. These practices increase the natural richness of bioactive compounds and contribute to the nutritional enrichment of the oil. However, excessive flavouring or fortification may result in unpleasant sensory sensations.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Review
Environmental Sciences
Solomon Ofori, Adela Puskacova, Iveta Ruzickova, Jiri Wanner
Summary: This article discusses the pros and cons of using treated wastewater for crop irrigation, analyzing environmental, public health, and economic impacts. Innovative measures are proposed to optimize benefits and mitigate drawbacks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Plant Sciences
Dimitris L. Bouranis, Styliani N. Chorianopoulou
Summary: This article discusses the fate, rationale, and efficiency of sulfur compound foliar applications. The foliar application of sulfur-containing compounds in various combinations is an emerging area in agriculture, and the importance of proper combinations is emphasized.
Review
Biochemical Research Methods
Mercy R. Benzigar, Ripon Bhattacharjee, Mahroo Baharfar, Guozhen Liu
Summary: The article discusses the current global efforts in combating the COVID-19 pandemic, emphasizing the development of early diagnostic tools to understand the transmission and infection mechanisms of SARS-CoV-2 virus. It also introduces the transmission of different types of coronaviruses among humans, as well as diagnostic methods for these coronaviruses.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Siddharth Birla, Arshia Angural, Arya Madathumchalil, Ritika V. Shende, Sharvani V. Shastry, Manjappa Mahadevappa, Sunil Kumar Shambhu, Prashant Vishwanath, Akila Prashant
Summary: Polypill is a combination of multiple drugs in a single pill, aiming to simplify drug regimen and reduce adverse effects. It has been widely used for treating cardiovascular diseases by targeting key modifiable risk factors. However, recent clinical trials have yielded contradictory findings, leading to skepticism about its widespread use in primary disease prevention.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Aymen Bahsoun, Yeva Fakih, Rana Zareef, Fadi Bitar, Mariam Arabi
Summary: The COVID-19 pandemic has burdened the global healthcare sector, leading to urgent efforts for a solution. Drug repurposing, specifically the use of corticosteroids, has shown promising results in decreasing COVID-19 mortality and morbidity. However, the quality and design of clinical trials vary, which makes this study necessary to explore the role of corticosteroids in treating COVID-19.
FRONTIERS IN MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Kavindi Jayawickreme, Dawid Swistak, Ewa Ozimek, Emilia Reszczynska, Anna Rysiak, Anna Makuch-Kocka, Agnieszka Hanaka
Summary: This article examines heterocyclic organic compounds called pyrrolizidine alkaloids (PAs), which are synthesized by plants or microorganisms and are naturally occurring secondary metabolites. The authors summarize the structure, metabolism, and effects of PAs on humans, including both negative toxic effects and potential pharmacological applications. The article also discusses the anticancer and antimicrobial potential of PAs from plant and microbial sources, and suggests future applications and perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Andrey A. Poloznikov, Stepan A. Nersisyan, Dmitry M. Hushpulian, Eliot H. Kazakov, Alexander G. Tonevitsky, Sergey Kazakov, Valery Vechorko, Sergey Nikulin, Julia A. Makarova, Irina G. Gazaryan
Summary: The review discusses the potential benefits and challenges of using HIF prolyl hydroxylase inhibitors as a treatment for COVID-19. While they may be beneficial for treating COVID-19 complications, they are unlikely to prevent initial infection stages.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Qijie Zhao, Yu Jiang, Shixin Xiang, Parham Jabbarzadeh Kaboli, Jing Shen, Yueshui Zhao, Xu Wu, Fukuan Du, Mingxing Li, Chi Hin Cho, Jing Li, Qinglian Wen, Tao Liu, Tao Yi, Zhangang Xiao
Summary: This review provides insights into the role of engineered T-cell receptors (TCRs) in immunotherapy and discusses novel approaches to enhance anticancer immune system. It also highlights the importance of safety in genetically modified T cells and explores different strategies such as ImmTAC, HSV-TK, and inducible caspase-9 in cancer immunotherapy. Clinical trials related to TCR-T cell therapy and monoclonal antibodies designed to overcome immunosuppression are also discussed, along with recent advances in understanding TCRs and new approaches to detect antigens and drive effective T cell response.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kyung Hyun Lee, Seongcheol Kim, Seong-Wook Lee
Summary: This review introduces the methods of manufacturing circular RNA as a new therapeutic agent and vaccine, discusses the advantages and disadvantages of circular RNA, and explores the research directions for improving its efficacy and productivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gina Manda, Elena Milanesi, Sermin Genc, Cristina Mariana Niculite, Ionela Victoria Neagoe, Bora Tastan, Elena Mihaela Dragnea, Antonio Cuadrado
Summary: This review focuses on the arguments for using NRF2-directed co-treatment in RA and its limitations, highlighting the importance of NRF2 in RA through analysis of transcriptomic data and animal experiments. The potential of NRF2 activators in drug development and the interference of NRF2 with conventional anti-rheumatic therapies are also discussed.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Cell Biology
Adel Naimi, Rebar N. Mohammed, Ahmed Raji, Supat Chupradit, Alexei Valerievich Yumashev, Wanich Suksatan, Mohammed Nader Shalaby, Lakshmi Thangavelu, Siavash Kamrava, Navid Shomali, Armin D. Sohrabi, Ali Adili, Ali Noroozi-Aghideh, Ehsan Razeghian
Summary: The discovery of immune checkpoint proteins led to the development of immune checkpoint inhibitors (ICIs), a promising approach in tumor immunotherapy. However, resistance and treatment-related toxicities remain challenges in the clinical application of ICIs.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Dermatology
Kevin S. Kim, An-Wen Chan, Emilie P. Belley-Cote, Aaron M. Drucker
Summary: Noninferiority trials, which assess the comparability of a new treatment with the standard of care, have increased significantly in publication from 2005 to 2015. These trials differ from superiority trials in various aspects of trial design and have unique considerations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)