Measuring the Impact of Genetic Heterogeneity and Chromosomal Inversions on the Efficacy of CRISPR-Cas9 Gene Drives in Different Strains of Anopheles gambiae

Considerations for homology-based DNA repair in mosquitoes: Impact of sequence heterology and donor template source

(2022) Joshua Xin De Ang et al.   PLoS Genetics

Testing non-autonomous antimalarial gene drive effectors using self-eliminating drivers in the African mosquito vector Anopheles gambiae

(2022) David A. Ellis et al.   PLoS Genetics

A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation

(2022) Bhavin S. Khatri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Introgression of a synthetic sex ratio distortion transgene into different genetic backgrounds of Anopheles coluzzii

(2022) Paola Pollegioni et al.   INSECT MOLECULAR BIOLOGY

Assessing single-locus CRISPR/Cas9-based gene drive variants in the mosquito Aedes aegypti via single generation crosses and modeling

(2022) William Reid et al.   G3-Genes Genomes Genetics

Gene drive mosquitoes can aid malaria elimination by retarding Plasmodium sporogonic development

(2022) Astrid Hoermann et al.   Science Advances

Regulating the expression of gene drives is key to increasing their invasive potential and the mitigation of resistance

(2021) Andrew Hammond et al.   PLoS Genetics

DNA Repair Pathway Choices in CRISPR-Cas9-Mediated Genome Editing

(2021) Chaoyou Xue et al.   TRENDS IN GENETICS

Double drives and private alleles for localised population genetic control

(2021) Katie Willis et al.   PLoS Genetics

Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

(2021) Astrid Hoermann et al.   eLife

Gene drive strategies of pest control in agricultural systems: Challenges and opportunities

(2021) Mathieu Legros et al.   Evolutionary Applications

Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing

(2020) Stephanie L. James et al.   VECTOR-BORNE AND ZOONOTIC DISEASES

Genome variation and population structure among 1142 mosquitoes of the African malaria vector species Anopheles gambiae and Anopheles coluzzii

(2020)   GENOME RESEARCH

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population

(2020) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Residual Malaria: Limitations of Current Vector Control Strategies to Eliminate Transmission in Residual Foci

(2020) Mario H Rodriguez   JOURNAL OF INFECTIOUS DISEASES

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect

(2019) Jackson Champer et al.   GENETICS

Daisy-chain gene drives for the alteration of local populations

(2019) Charleston Noble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tethered homing gene drives: a new design for spatially restricted population replacement and suppression

(2019) Sumit Dhole et al.   Evolutionary Applications

Efficient allelic-drive in Drosophila

(2019) Annabel Guichard et al.   Nature Communications

Gene drive for population genetic control: non-functional resistance and parental effects

(2019) Andrea K. Beaghton et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Meiotic drive mechanisms: lessons from Drosophila

(2019) Cécile Courret et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Reducing resistance allele formation in CRISPR gene drive

(2018) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local Inversion Heterozygosity Alters Recombination throughout the Genome

(2018) K. Nicole Crown et al.   CURRENT BIOLOGY

Association mapping desiccation resistance within chromosomal inversions in the African malaria vector Anopheles gambiae

(2018) Diego Ayala et al.   MOLECULAR ECOLOGY

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Variation in recombination frequency and distribution across eukaryotes: patterns and processes

(2017) Jessica Stapley et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

(2017) Andrew M. Hammond et al.   PLoS Genetics

Overcoming evolved resistance to population-suppressing homing-based gene drives

(2017) John M. Marshall et al.   Scientific Reports

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster

(2016) Chad M. Hunter et al.   PLoS Genetics

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation

(2014) Chris S. Clarkson et al.   Nature Communications

Chromosome Inversions, Genomic Differentiation and Speciation in the African Malaria Mosquito Anopheles gambiae

(2013) Yoosook Lee et al.   PLoS One

Double-Strand Break Repair Assays Determine Pathway Choice and Structure of Gene Conversion Events in Drosophila melanogaster

(2013) Anthony T. Do et al.   G3-Genes Genomes Genetics

Adaptation to Aridity in the Malaria Mosquito Anopheles gambiae: Chromosomal Inversion Polymorphism and Body Size Influence Resistance to Desiccation

(2012) Caroline Fouet et al.   PLoS One

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

(2011) Nikolai Windbichler et al.   NATURE

How and Why Chromosome Inversions Evolve

(2010) Mark Kirkpatrick   PLOS BIOLOGY

Polymorphisms in Anopheles gambiae Immune Genes Associated with Natural Resistance to Plasmodium falciparum

(2010) Caroline Harris et al.   PLoS Pathogens

Inversion 2La is associated with enhanced desiccation resistance in Anopheles gambiae

(2009) Emilie M Gray et al.   MALARIA JOURNAL

A test of the chromosomal theory of ecotypic speciation in Anopheles gambiae

(2008) N. C. Manoukis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA