Combination of genomic instability score and TP53 status for prognosis prediction in lung adenocarcinoma

Homologous recombination deficiency in diverse cancer types and its correlation with platinum chemotherapy efficiency in ovarian cancer

(2022) Hao Wen et al.   BMC CANCER

Homologous recombination deficiency (HRD) can predict the therapeutic outcomes of immuno-neoadjuvant therapy in NSCLC patients

(2022) Zhen Zhou et al.   Journal of Hematology & Oncology

Concurrent TP53 Mutations Facilitate Resistance Evolution in EGFR-Mutant Lung Adenocarcinoma

(2022) Natalie I. Vokes et al.   Journal of Thoracic Oncology

Homologous recombination deficiency (HRD) score in aggressive prostatic adenocarcinoma with or without intraductal carcinoma of the prostate (IDC-P)

(2022) Sha Zhu et al.   BMC Medicine

Ordered and deterministic cancer genome evolution after p53 loss

(2022) Timour Baslan et al.   NATURE

Pan-cancer analysis of genomic scar patterns caused by homologous repair deficiency (HRD)

(2022) E. Rempel et al.   npj Precision Oncology

A Phase II Study of Talazoparib in Patients with Homologous Recombination Repair Deficient Squamous Cell Lung Cancer (Lung-MAP Sub-Study S1400G)

(2021) Taofeek K. Owonikoko et al.   Clinical Lung Cancer

Homologous recombination deficiency (HRD) score in germline BRCA2- versus ATM-altered prostate cancer

(2021) Tamara L. Lotan et al.   MODERN PATHOLOGY

Alterations of DNA damage response pathway: Biomarker and therapeutic strategy for cancer immunotherapy

(2021) Minlin Jiang et al.   Acta Pharmaceutica Sinica B

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A subset of lung cancer cases shows robust signs of homologous recombination deficiency associated genomic mutational signatures

(2021) Miklos Diossy et al.   npj Precision Oncology

Pan-cancer Analysis of Homologous Recombination Repair-associated Gene Alterations and Genome-wide Loss of Heterozygosity Score

(2021) Benedikt Westphalen et al.   CLINICAL CANCER RESEARCH

Genomic signatures define three subtypes of EGFR-mutant stage II–III non-small-cell lung cancer with distinct adjuvant therapy outcomes

(2021) Si-Yang Liu et al.   Nature Communications

Genomic landscape of lung adenocarcinoma in East Asians

(2020) Jianbin Chen et al.   NATURE GENETICS

Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

(2020) Elsa Bernard et al.   NATURE MEDICINE

Predictive and Prognostic Potential of TP53 in Patients With Advanced Non–Small-Cell Lung Cancer Treated With EGFR-TKI: Analysis of a Phase III Randomized Clinical Trial (CTONG 0901)

(2020) Xiang-Meng Li et al.   Clinical Lung Cancer

Tumor mutational load predicts survival after immunotherapy across multiple cancer types

(2019) Robert M. Samstein et al.   NATURE GENETICS

Detecting the mutational signature of homologous recombination deficiency in clinical samples

(2019) Doga C. Gulhan et al.   NATURE GENETICS

Integrated Analysis of TP53 Gene and Pathway Alterations in The Cancer Genome Atlas

(2019) Lawrence A. Donehower et al.   Cell Reports

Niraparib in Patients with Newly Diagnosed Advanced Ovarian Cancer

(2019) Antonio González-Martín et al.   NEW ENGLAND JOURNAL OF MEDICINE

Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer

(2019) Isabelle Ray-Coquard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biomarkers for Homologous Recombination Deficiency in Cancer

(2018) Michal M Hoppe et al.   JNCI-Journal of the National Cancer Institute

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Biomarkers for Homologous Recombination Deficiency in Cancer

(2018) Michal M Hoppe et al.   JNCI-Journal of the National Cancer Institute

Survival analysis of carboplatin added to an anthracycline/taxane-based neoadjuvant chemotherapy and HRD score as predictor of response—final results from GeparSixto

(2018) S Loibl et al.   ANNALS OF ONCOLOGY

Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas

(2018) Marthe M. de Jonge et al.   CLINICAL CANCER RESEARCH

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures

(2017) Helen Davies et al.   NATURE MEDICINE

Tracking the Evolution of Non–Small-Cell Lung Cancer

(2017) Mariam Jamal-Hanjani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer

(2016) M. L. Telli et al.   CLINICAL CANCER RESEARCH

Impact of TP53 Mutations on Outcome in EGFR -Mutated Patients Treated with First-Line Tyrosine Kinase Inhibitors

(2016) Matteo Canale et al.   CLINICAL CANCER RESEARCH

Potential Predictive Value of TP53 and KRAS Mutation Status for Response to PD-1 Blockade Immunotherapy in Lung Adenocarcinoma

(2016) Zhong-Yi Dong et al.   CLINICAL CANCER RESEARCH

Cancer Genomics: Diversity and Disparity Across Ethnicity and Geography

(2016) Daniel S.W. Tan et al.   JOURNAL OF CLINICAL ONCOLOGY

FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution

(2014) Aaron M. Newman et al.   BIOINFORMATICS

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

(2012) V Abkevich et al.   BRITISH JOURNAL OF CANCER

Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 Inactivation

(2012) T. Popova et al.   CANCER RESEARCH

A program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff

(2012) Pablo Cingolani et al.   FLY

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents

(2012) Nicolai J. Birkbak et al.   Cancer Discovery

Ethnic Differences in Survival Outcome in Patients with Advanced Stage Non-small Cell Lung Cancer: Results of a Meta-Analysis of Randomized Controlled Trials

(2011) Ross A. Soo et al.   Journal of Thoracic Oncology

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS