Journal
NATURE IMMUNOLOGY
Volume 17, Issue 8, Pages 900-902Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni.3511
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Funding
- NCI NIH HHS [P30 CA060553] Funding Source: Medline
- NIAID NIH HHS [R01 AI120625, R01 AI099009, R21 AI120618] Funding Source: Medline
- NIAMS NIH HHS [K01 AR066739, R01 AR064349] Funding Source: Medline
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The Pyrin inflammasome guard is disabled if the activity of small cellular GTPase is compromised in response to defects in the mevalonate pathway and is disabled directly by mutations in the gene encoding Pyrin, which results in the interleukin 1 beta (IL-1 beta)-driven autoinflammatory diseases MKD and FMF.
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