A method for identifying genetic heterogeneity within phenotypically defined disease subgroups

The fine-scale genetic structure of the British population

(2015) Stephen Leslie et al.   NATURE

Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls

(2015) Mary D Fortune et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Efficient Bayesian mixed-model analysis increases association power in large cohorts

(2015) Po-Ru Loh et al.   NATURE GENETICS

Identification of type 2 diabetes subgroups through topological analysis of patient similarity

(2015) Li Li et al.   Science Translational Medicine

A Pleiotropy-Informed Bayesian False Discovery Rate Adapted to a Shared Control Design Finds New Disease Associations From GWAS Summary Statistics

(2015) James Liley et al.   PLoS Genetics

Using Phenotypic Heterogeneity to Increase the Power of Genome-Wide Association Studies: Application to Age at Onset of Ischaemic Stroke Subphenotypes

(2013) Matthew Traylor et al.   GENETIC EPIDEMIOLOGY

A Multiclass Likelihood Ratio Approach for Genetic Risk Prediction Allowing for Phenotypic Heterogeneity

(2013) Yalu Wen et al.   GENETIC EPIDEMIOLOGY

Improved Detection of Common Variants Associated with Schizophrenia and Bipolar Disorder Using Pleiotropy-Informed Conditional False Discovery Rate

(2013) Ole A. Andreassen et al.   PLoS Genetics

Improved Heritability Estimation from Genome-wide SNPs

(2012) Doug Speed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood

(2012) S.H. Lee et al.   BIOINFORMATICS

Evidence of Gene-Gene Interaction and Age-at-Diagnosis Effects in Type 1 Diabetes

(2012) J. M. M. Howson et al.   DIABETES

Seven newly identified loci for autoimmune thyroid disease

(2012) Jason D. Cooper et al.   HUMAN MOLECULAR GENETICS

Genetic Analysis of Adult-Onset Autoimmune Diabetes

(2011) J. M. M. Howson et al.   DIABETES

Promise and pitfalls of the Immunochip

(2011) Adrian Cortes et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Association Analysis of Autoantibody Positivity in Type 1 Diabetes Cases

(2011) Vincent Plagnol et al.   PLoS Genetics

Data quality control in genetic case-control association studies

(2010) Carl A Anderson et al.   Nature Protocols

Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families

(2009) J M M Howson et al.   GENES AND IMMUNITY

A powerful approach to sub-phenotype analysis in population-based genetic association studies

(2009) Andrew P. Morris et al.   GENETIC EPIDEMIOLOGY

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS