Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides
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Title
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides
Authors
Keywords
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Journal
Nature Biomedical Engineering
Volume 7, Issue 9, Pages 1170-1187
Publisher
Springer Science and Business Media LLC
Online
2023-08-31
DOI
10.1038/s41551-023-01085-3
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Note: Only part of the references are listed.- Decade-long leukaemia remissions with persistence of CD4+ CAR T cells
- (2022) J. Joseph Melenhorst et al. NATURE
- CRISPR activation and interference screens decode stimulation responses in primary human T cells
- (2022) Ralf Schmidt et al. SCIENCE
- BCL6-dependent TCF-1+ progenitor cells maintain effector and helper CD4+ T cell responses to persistent antigen
- (2022) Yu Xia et al. IMMUNITY
- Molecular signatures of antitumor neoantigen-reactive T cells from metastatic human cancers
- (2022) Frank J. Lowery et al. SCIENCE
- Next-Generation CAR T-cell Therapies
- (2022) Regina M. Young et al. Cancer Discovery
- Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
- (2022) Julia A. Belk et al. CANCER CELL
- Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq
- (2022) Joseph M. Replogle et al. CELL
- In vivo screens using a selective CRISPR antigen removal lentiviral vector system reveal immune dependencies in renal cell carcinoma
- (2021) Juan Dubrot et al. IMMUNITY
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Cycling cancer persister cells arise from lineages with distinct programs
- (2021) Yaara Oren et al. NATURE
- Identifying transcriptional programs underlying cancer drug response with TraCe-seq
- (2021) Matthew T. Chang et al. NATURE BIOTECHNOLOGY
- An NK-like CAR T cell transition in CAR T cell dysfunction
- (2021) Charly R. Good et al. CELL
- Identifying phenotype-associated subpopulations by integrating bulk and single-cell sequencing data
- (2021) Duanchen Sun et al. NATURE BIOTECHNOLOGY
- Pan-cancer single-cell landscape of tumor-infiltrating T cells
- (2021) Liangtao Zheng et al. SCIENCE
- Lineage tracing on transcriptional landscapes links state to fate during differentiation
- (2020) Caleb Weinreb et al. SCIENCE
- SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy
- (2020) Zhentian Wang et al. CANCER CELL
- Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
- (2020) Theodore L. Roth et al. CELL
- Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing
- (2020) Joseph M. Replogle et al. NATURE BIOTECHNOLOGY
- Souporcell: robust clustering of single-cell RNA-seq data by genotype without reference genotypes
- (2020) Haynes Heaton et al. NATURE METHODS
- Tuning the Antigen Density Requirement for CAR T-cell Activity
- (2020) Robbie G. Majzner et al. Cancer Discovery
- Intratumoral CD4+ T Cells Mediate Anti-tumor Cytotoxicity in Human Bladder Cancer
- (2020) David Y. Oh et al. CELL
- Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy
- (2020) Theodore S Nowicki et al. Cancer Discovery
- Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin
- (2020) Sai Ma et al. CELL
- Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
- (2020) Qing Deng et al. NATURE MEDICINE
- In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes
- (2020) Xin Jin et al. SCIENCE
- Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer
- (2020) Sri Krishna et al. SCIENCE
- Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
- (2019) Sema Kurtulus et al. IMMUNITY
- Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy
- (2019) Imran Siddiqui et al. IMMUNITY
- Identification of preexisting adaptive immunity to Cas9 proteins in humans
- (2019) Carsten T. Charlesworth et al. NATURE MEDICINE
- Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade
- (2019) Brian C. Miller et al. NATURE IMMUNOLOGY
- Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts
- (2019) Jacob L. Litke et al. NATURE BIOTECHNOLOGY
- Multiplexed detection of proteins, transcriptomes, clonotypes and CRISPR perturbations in single cells
- (2019) Eleni P. Mimitou et al. NATURE METHODS
- DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors
- (2019) Christopher S. McGinnis et al. Cell Systems
- MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices
- (2019) Christopher S. McGinnis et al. NATURE METHODS
- High-throughput sequencing of the transcriptome and chromatin accessibility in the same cell
- (2019) Song Chen et al. NATURE BIOTECHNOLOGY
- c-Jun overexpression in CAR T cells induces exhaustion resistance
- (2019) Rachel C. Lynn et al. NATURE
- Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins
- (2019) Jase Gehring et al. NATURE BIOTECHNOLOGY
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy
- (2019) Sarwish Rafiq et al. Nature Reviews Clinical Oncology
- Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia
- (2018) Joseph A. Fraietta et al. NATURE MEDICINE
- An enhanced CRISPR repressor for targeted mammalian gene regulation
- (2018) Nan Cher Yeo et al. NATURE METHODS
- Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia
- (2018) Jae H. Park et al. NEW ENGLAND JOURNAL OF MEDICINE
- Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function
- (2018) Eric Shifrut et al. CELL
- Coupled Single-Cell CRISPR Screening and Epigenomic Profiling Reveals Causal Gene Regulatory Networks
- (2018) Adam J. Rubin et al. CELL
- Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
- (2018) Moshe Sade-Feldman et al. CELL
- Single-cell mapping of lineage and identity in direct reprogramming
- (2018) Brent A. Biddy et al. NATURE
- Dimensionality reduction for visualizing single-cell data using UMAP
- (2018) Etienne Becht et al. NATURE BIOTECHNOLOGY
- Multiplexed droplet single-cell RNA-sequencing using natural genetic variation
- (2017) Hyun Min Kang et al. NATURE BIOTECHNOLOGY
- SCENIC: single-cell regulatory network inference and clustering
- (2017) Sara Aibar et al. NATURE METHODS
- Pooled CRISPR screening with single-cell transcriptome readout
- (2017) Paul Datlinger et al. NATURE METHODS
- Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma
- (2017) Sattva S. Neelapu et al. NEW ENGLAND JOURNAL OF MEDICINE
- Massively parallel digital transcriptional profiling of single cells
- (2017) Grace X. Y. Zheng et al. Nature Communications
- Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia
- (2017) Xiaoyin Lu et al. Cell Reports
- Complex heatmaps reveal patterns and correlations in multidimensional genomic data
- (2016) Zuguang Gu et al. BIOINFORMATICS
- Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies
- (2016) M. Sabatino et al. BLOOD
- Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
- (2016) Diego Adhemar Jaitin et al. CELL
- Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
- (2016) Atray Dixit et al. CELL
- A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
- (2016) Britt Adamson et al. CELL
- Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors
- (2016) Leonardo Morsut et al. CELL
- Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
- (2016) Willy Hugo et al. CELL
- T Cell Factor 1-Expressing Memory-like CD8 + T Cells Sustain the Immune Response to Chronic Viral Infections
- (2016) Daniel T. Utzschneider et al. IMMUNITY
- CRISPR-Cas9 nuclear dynamics and target recognition in living cells
- (2016) Hanhui Ma et al. JOURNAL OF CELL BIOLOGY
- BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models
- (2016) Yuki Kagoya et al. JOURNAL OF CLINICAL INVESTIGATION
- Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
- (2016) Se Jin Im et al. NATURE
- Revealing the vectors of cellular identity with single-cell genomics
- (2016) Allon Wagner et al. NATURE BIOTECHNOLOGY
- A multifunctional AAV–CRISPR–Cas9 and its host response
- (2016) Wei Leong Chew et al. NATURE METHODS
- Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells
- (2015) Zeguo Zhao et al. CANCER CELL
- In-Gel Imaging of RNA Processing Using Broccoli Reveals Optimal Aptamer Expression Strategies
- (2015) Grigory S. Filonov et al. CHEMISTRY & BIOLOGY
- T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial
- (2015) Daniel W Lee et al. LANCET
- 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
- (2015) Adrienne H Long et al. NATURE MEDICINE
- Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15
- (2014) Y. Xu et al. BLOOD
- Improved vectors and genome-wide libraries for CRISPR screening
- (2014) Neville E Sanjana et al. NATURE METHODS
- Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia
- (2014) Shannon L. Maude et al. NEW ENGLAND JOURNAL OF MEDICINE
- Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
- (2013) Lei S. Qi et al. CELL
- Programmable folding of fusion RNA in vivo and in vitro driven by pRNA 3WJ motif of phi29 DNA packaging motor
- (2013) Dan Shu et al. NUCLEIC ACIDS RESEARCH
- IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors
- (2012) N. Cieri et al. BLOOD
- Thermodynamically stable RNA three-way junction for constructing multifunctional nanoparticles for delivery of therapeutics
- (2011) Dan Shu et al. Nature Nanotechnology
- Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells
- (2009) Luca Gattinoni et al. NATURE MEDICINE
- Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition
- (2008) S Yang et al. GENE THERAPY
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