Article
Dentistry, Oral Surgery & Medicine
Saubhik Dasukil, Geetanjali Arora, Kiran Kumar Boyina, Ashok Kumar Jena, Anson Jose, Snigdho Das
Summary: This study compared the efficacy of intra-articular injections of platelet-rich plasma (PRP) and hyaluronic acid (HA) in the treatment of TMJ internal derangement following single needle arthrocentesis. The results showed that PRP treatment significantly reduced pain and joint clicking sounds, and improved maximum mouth opening.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2022)
Review
Medicine, General & Internal
Maciej Checinski, Kamila Checinska, Natalia Turosz, Maciej Sikora, Dariusz Chlubek
Summary: This systematic review and meta-analysis aimed to validate the hypothesis that intra-articular injections into the inferior temporomandibular joint compartment are more efficient than analogous superior compartment interventions. The results showed a significant advantage of inferior over superior compartment temporomandibular joint intra-articular injections in improving articular pain, decreasing the Helkimo index, and increasing maximum mouth opening. However, further research is needed to overcome limitations such as the small number of eligible studies and discrepancies in substances used.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Kanyakorn Riewruja, Suphattra Phakham, Patlapa Sompolpong, Rangsima Reantragoon, Aree Tanavalee, Srihatach Ngarmukos, Wanvisa Udomsinprasert, Tanyawan Suantawee, Sinsuda Dechsupa, Sittisak Honsawek
Summary: This study examined the cytokine profile in PRP and PPP of knee OA patients and investigated the effects of PRP on OA chondrocytes and knee OA patients. The results showed that PRP contained a wide variety of cytokines, chemokines, and growth factors, and intra-articular PRP injection had favorable outcomes in knee OA patients. The findings suggest that PRP treatment may be a potential therapeutic strategy for alleviating knee pain and delaying the need for surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Yu-Ning Peng, Jean-Lon Chen, Chih-Chin Hsu, Carl P. C. Chen, Areerat Suputtitada
Summary: LR-PRP injection showed better overall outcomes compared to HA injection in knee osteoarthritis patients at follow-up periods of 3, 6, and 12 months. However, there was no significant pain relief effect compared to HA injection. LR-PRP injection may be recommended as a feasible option in treating patients with knee osteoarthritis.
Article
Orthopedics
Zhe Xu, Zhixu He, Liping Shu, Xuanze Li, Minxian Ma, Chuan Ye
Summary: The combination of platelet-rich plasma (PRP) and hyaluronic acid (HA) was found to be more effective in inhibiting synovial inflammation, improving pain and function, and reducing adverse reactions in knee osteoarthritis (KOA) compared to PRP or HA alone. This combination therapy showed promising results through changes in synovial tissue and cytokine levels.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Chemistry, Physical
Ke Ren, Hongping Wan, Hans J. Kaper, Prashant K. Sharma
Summary: In this study, hyaluronic acid (HA) was conjugated with dopamine to form HADN, which exhibited adhesive properties while retaining viscosity enhancement capacity. It was found that HADN could enhance cartilage lubrication through adsorption onto collagen, providing better protection for cartilage compared to HA alone.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Medicine, Research & Experimental
Ming Li, Zheyu Huang, Shicheng Wang, Zhenglin Di, Junhui Zhang, Hua Liu
Summary: The study compared the clinical and economic benefits of PRP and HA injections in Chinese patients with knee OA. Both treatments significantly improved clinical scores, but PRP was associated with more severe adverse reactions, higher costs, and longer treatment times.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Medicine, General & Internal
Yung-Tsan Wu, Tsung-Ying Li, Kuei-Chen Lee, King Hei Stanley Lam, Chih-Ya Chang, Cheng-Kuang Chang, Liang-Cheng Chen
Summary: Recent studies suggest that the combined injection of PRP and HA may have additional benefits for knee osteoarthritis. This study aimed to assess their combined efficacy with a novel injection protocol. The results showed that the intervention group, receiving PRP and HA according to the new protocol, had significant improvements in pain, stiffness, total scores, and static balance compared to the control group.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kim L. Bennell, Kade L. Paterson, Ben R. Metcalf, Vicky Duong, Jillian Eyles, Jessica Kasza, Yuanyuan Wang, Flavia Cicuttini, Rachelle Buchbinder, Andrew Forbes, Anthony Harris, Shirley P. Yu, David Connell, James Linklater, Bing Hui Wang, Win Min Oo, David J. Hunter
Summary: This study found that intra-articular injection of PRP did not significantly improve symptoms or slow disease progression in patients with mild to moderate knee osteoarthritis compared to saline placebo injection at 12 months.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Review
Medicine, General & Internal
Sabryne Berkani, Alice Courties, Florent Eymard, Augustin Latourte, Pascal Richette, Francis Berenbaum, Jeremie Sellam, Karine Louati
Summary: Intra-articular hyaluronic acid injections can delay the time to total knee arthroplasty (TKA) among knee osteoarthritis (KOA) patients. However, the effects of platelet-rich plasma (PRP) injections on TKA delay are still unclear.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Orthopedics
Mark Phillips, Mohit Bhandari, John Grant, Asheesh Bedi, Thomas Trojian, Aaron Johnson, Emil Schemitsch
Summary: This study reviewed the role of injections in nonoperative management of knee osteoarthritis, focusing on intra-articular hyaluronic acid, intra-articular corticosteroids, and platelet-rich plasma. It found that most guidelines support the use of intra-articular hyaluronic acid and intra-articular corticosteroids for symptom relief in knee osteoarthritis.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Seyed Ahmad Raeissadat, Parsa Ghazi Hosseini, Mohammad Hasan Bahrami, Reza Salman Roghani, Mohammad Fathi, Azadeh Gharooee Ahangar, Mahtab Darvish
Summary: Ozone injection showed rapid effects and better short-term results after 2 months, but its therapeutic effects did not persist after 6 months. PRP and PRGF were superior to ozone in long-term management, with the effects lasting for 12 months.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Songul Comert Kilic
Summary: This study compared the clinical outcomes of supplementing glucosamine, chondroitin sulfate, and methylsulfonylmethane after arthrocentesis plus intraarticular hyaluronic acid injection with treatment involving only hyaluronic acid injection for TMJ-OA. The results indicated that there were no significant additional clinical benefits or improvements for patients receiving GCM supplementation compared to those receiving only intraarticular HA injection.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marcel Tschopp, Christian W. A. Pfirrmann, Sandro F. Fucentese, Florian Brunner, Sabrina Catanzaro, Nathalie Kuhne, Iwan Zwyssig, Reto Sutter, Tobias Gotschi, Matteo Tanadini, Andrea B. Rosskopf
Summary: This study aimed to compare the clinical outcomes of intra-articular injections of glucocorticoid, hyaluronic acid, platelet-rich plasma (PRP), or placebo in patients with mild or moderate knee osteoarthritis (OA). The results showed that glucocorticoid, PRP, or hyaluronic acid injections did not have superior short- or long-term effects compared to placebo in patients with low pain level and early- to middle-stage knee OA.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Veterinary Sciences
Kristina Raulinaite, Rasa Zelvyte, Kristina Skemiene, Evelina Burbaite, Birute Karveliene, Ingrida Monkeviciene
Summary: Cranial cruciate ligament rupture and patellar luxation are common pathologies in canines. Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for treatment, but platelet-rich plasma (PRP) may be a more beneficial option. This study compared the effects of PRP and NSAIDs on clinical outcomes and inflammatory cytokine levels in dogs with these conditions. The results showed that PRP treatment was more effective than NSAIDs in managing the inflammatory processes and improving clinical outcomes in canine cranial cruciate ligament rupture and patellar luxation.
VETERINARY SCIENCES
(2023)
