Journal
NATURE CELL BIOLOGY
Volume 18, Issue 10, Pages 1027-1029Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3414
Keywords
-
Categories
Funding
- Novo Nordisk Foundation Section for Basic Stem Cell Biology [Helin group NNF] Funding Source: researchfish
Ask authors/readers for more resources
Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of alpha-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
