Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Editorial Material
Biochemistry & Molecular Biology
Christine Merlin
Summary: The molecular mechanism behind organisms' ability to anticipate variations in environmental conditions caused by tides in the intertidal zone has been unknown. A recent study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms.
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sanjeev Kumar Soni, Priyoneel Basu, Muniyandi Singaravel, Ramaswamy Sharma, Seithikurippu R. Pandi-Perumal, Daniel. P. Cardinali, Russel J. Reiter
Summary: SIRT1 plays a crucial role in regulating cardioprotection through modulating the activity of CLOCK, a core clock gene. It has protective effects in preventing atherosclerotic plaque formation, shielding the heart from oxidative damage, but elevated levels may lead to cardiac hypertrophy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Luba Sominsky, Tamara Dangel, Sajida Malik, Simone N. De Luca, Nicolas Singewald, Sarah J. Spencer
Summary: Microglia play essential roles not only in immune defense but also in regulating satiety, memory, and pain responses. These functions are significantly influenced by circadian rhythmicity, impacting various physiological processes throughout the day.
Editorial Material
Cell Biology
Susmita Kaushik, Yves R. Juste, Ana Maria Cuervo
Summary: The circadian clock and chaperone-mediated autophagy (CMA) have an interdependent relationship. CMA selectively degrades core clock proteins, modulating circadian rhythm. Loss of CMA disrupts physiological circadian cycling, similar to defects observed in aging. The circadian clock temporally regulates CMA activity in different tissues, contributing to remodeling of a distinct subproteome at different times.
Review
Biochemistry & Molecular Biology
Andrew Salazar, Joerg von Hagen
Summary: Periodically oscillating biological processes, such as circadian rhythms, play a crucial role in tissue pathology, organismal health, and molecular mechanisms. Recent reports challenge the prevailing hierarchical model by suggesting that light can independently affect peripheral circadian clocks. However, there is a lack of comprehensive overview regarding these processes in the skin. This review highlights the molecular circadian clock machinery and factors governing it, and emphasizes the link between circadian rhythm, immunological processes, and skin homeostasis as well as its impact on the skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Satoshi Nomura, Takashi Hosono, Masanori Ono, Takiko Daikoku, Mieda Michihiro, Kyosuke Kagami, Takashi Iizuka, Yuchen Chen, Yifan Shi, Jun-ichi Morishige, Tomoko Fujiwara, Hiroshi Fujiwara, Hitoshi Ando
Summary: Research suggests that skipping breakfast disrupts uterine functions in young women with dysmenorrhea, related to fasting during the early active phase. This study investigated the involvement of the uterine clock system in fasting-induced uterine dysfunction using a 28-hour interval-fed mouse model. The results showed that fluctuations in the timing of the first food intake impair the uterine clock oscillator system, reducing clock gene expressions and abolishing circadian rhythms.
JOURNAL OF NUTRITION
(2023)
Article
Multidisciplinary Sciences
Vojtech Kumpost, Daniela Vallone, Srinivas Babu Gondi, Nicholas S. Foulkes, Ralf Mikut, Lennart Hilbert
Summary: The circadian clock is a cellular mechanism that synchronizes biological processes with the time of day, with external light cues influencing its dynamics. Zebrafish-derived cell cultures provide a laboratory model for circadian entrainment due to their direct light-entrainable clocks. A stochastic oscillator model of the zebrafish circadian clock accurately predicts entrainment dynamics and changes in single-cell oscillator parameters, paving the way for large-scale screens to modify circadian clock function.
SCIENTIFIC REPORTS
(2021)