Article
Environmental Sciences
Li-Ping Tao, Xue Li, Ming-Zhu Zhao, Jing-Ru Shi, Si-Qi Ji, Wen-Yuan Jiang, Qiu-Ju Liang, Yu-Hang Lei, Yi-Yao Zhou, Rong Cheng, Zhe Shi, Wenhai Deng, Jiayin Zhu, Shu-Yun Zhang
Summary: Polycyclic aromatic hydrocarbons (PAHs), particularly chrysene, have toxic effects on the liver by increasing relative liver weight and elevated serum ALT levels; the hepatotoxicity of chrysene is dependent on the aryl hydrocarbon receptor (AhR), while Nrf2 plays a crucial role in protecting against oxidative liver injury induced by chrysene.
Article
Chemistry, Multidisciplinary
Erik B. Schiferle, Wenxu Ge, Bjorn M. Reinhard
Summary: Despite recycling efforts, plastic waste continues to accumulate in the oceans, leading to the production of micro-and nanoscale plastic particles that can transport carcinogens. The fate and potential threats associated with plastics are still largely unknown.
Article
Environmental Sciences
Narges Shamsedini, Mansooreh Dehghani, Mohammadreza Samaei, Aboolfazl Azhdarpoor, Mohammad Hosseini, Mohammad Fararoei, Shayan Bahrany
Summary: This study investigated the concentration of urinary PAHs in individuals living near restaurants, finding that they were exposed to higher levels of PAHs. The mean concentration of PAHs in urine was slightly lower in the control group compared to those living near restaurants. The concentration of PAH metabolites was directly related to MDA and TAC.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2022)
Review
Environmental Sciences
Rupa Rani, Abhidha Kela, Geeta Dhaniya, Kamini Arya, Amit K. Tripathi, Rajesh Ahirwar
Summary: Specific miRNAs have been identified as early warning biomarkers for health effects associated with exposure to PAHs in exposed populations, and they can serve as indicators of early health effects in response to chronic environmental exposure to PAHs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Emily C. Pisarski, Edward F. Wirth, Paul L. Pennington, Ian Hartwell, Brian S. Shaddrix, David R. Whitall, Dennis A. Apeti, Gregory Baker
Summary: This study tested six field cleaning techniques on metal sampling equipment and found that protocols containing a solvent step were more effective than protocols without solvents in reducing chemical carryover. Depending on the data quality objectives, the differences may not be meaningful, and choosing a cleaning technique should be governed by health, safety, and environmental factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Amber L. Kramer, Shelby Dorn, Allison Perez, Courtney Roper, Ivan A. Titaley, Kaylee Cayton, Ronald P. Cook, Paul H-Y Cheong, Staci L. Massey Simonich
Summary: This study measured the oxidative potential of 135 individual PAHs in PM2.5 and found a mismatch between DTT50 results and computed reduction potential values. The GINI equality index correlated with Delta G(rxn) values, indicating a link between electron dispersion and thermodynamic reactions in PAHs. The additive prediction model did not accurately predict the DTT consumption in the assay, suggesting a more complex toxicity model for PAHs in ambient PM2.5.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Imen Bouzidi, Anis Fkiri, Badreddine Sellami, Abdel Halim Harrath, Fehmi Boufahja, Amine Mezni, Loic Vidal, Cyril Vaulot, Ludovic Josien, Hamouda Beyrem, Karine Mougin
Summary: The study found that composite nanoparticles composed of different materials have a good photocatalytic degradation effect on polycyclic aromatic hydrocarbons, while also having a certain impact on marine organisms, possibly causing oxidative stress responses.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Ulrika Eriksson, Ivan A. Titaley, Magnus Engwall, Maria Larsson
Summary: Tire granulates recovered from end-of-life tires contain a complex mixture of toxic polyaromatic compounds (PACs), which are only partially monitored. This study used chemical analysis and bioassays to determine PAC concentrations and activities in tire granulates, revealing the presence of unknown bioactive compounds that contribute significantly to the effects observed. Further investigations are needed to identify and apportion these toxicants.
Article
Environmental Sciences
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang
Summary: This study aimed to investigate the association between urinary PAHs and cardiovascular diseases. The results showed a positive correlation between urinary PAHs and the prevalence of coronary heart disease, angina, heart attack, and stroke.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Bin Han, Qian Li, Ang Liu, Jinwen Gong, Li Zheng
Summary: In the surface sediments of Yazhou Bay in Sanya, the total content of PAHs falls within an acceptable range, predominantly originating from combustion sources, indicating a low overall ecological risk.
MARINE POLLUTION BULLETIN
(2021)
Article
Environmental Sciences
Kristen M. Prossner, Hamish J. Small, Ryan B. Carnegie, Michael A. Unger
Summary: Bivalve mollusks, including oysters, have a high susceptibility to accumulating lipophilic organic contaminants, such as polycyclic aromatic hydrocarbons (PAHs), due to their low metabolic potential. The consumption of oysters, which are known to have high levels of PAHs, can pose a serious public health concern in areas with high PAH contamination. This study presents a method to detect and locate complex mixtures of PAHs in oyster tissues using fluorescent immunohistochemistry, providing valuable insights into the internal partitioning mechanisms of PAH-exposed oysters and potential applications for studying PAH distribution in other organisms.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Eirini Chrysochou, Panagiotis Georgios Kanellopoulos, Konstantinos G. Koukoulakis, Aikaterini Sakellari, Sotirios Karavoltsos, Minas Minaidis, Evangelos Bakeas
Summary: The study aimed to assess the potential relationship between environmental pollutants and heart failure, with specific polycyclic aromatic hydrocarbons and trace elements possibly being linked to heart failure development. Atmospheric degradation and smoking habit significantly impacted the serum concentrations of the analytes.
Article
Engineering, Environmental
Pawel Swit, Joanna Orzel, Slawomir Maslanka
Summary: This article introduces an integrated calibration method combining external calibration and standard addition method, which is used to improve the quality of multi-component analysis. The proposed method was evaluated by analyzing polycyclic aromatic hydrocarbons in various environmental samples from the Katowice region in Poland. The method proved effective in eliminating interference and producing consistent results.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Oceanography
Lei Du, Li Zhang, Ruijie Liu, Yikang Gu
Summary: With the widespread use of scrubbers on ships, there is growing concern about the potential environmental risk of scrubber washwater, particularly the presence of toxic pollutants known as Polycyclic Aromatic Hydrocarbons (PAHs). Current lab analysis methods and monitoring devices may underestimate the actual PAHs concentrations in scrubber effluent, leading to controversy and confusion regarding the impact of scrubber effluent on the marine environment.
OCEAN & COASTAL MANAGEMENT
(2022)
Article
Environmental Sciences
Agnieszka Krzyszczak, Michal P. Dybowski, Magdalena Konczak, Bozena Czech
Summary: In recent years, there has been significant progress in the study of thermal transformation of waste into valuable materials such as biochar. High-temperature processes can lead to the formation of toxic polycyclic aromatic hydrocarbons (PAHs). However, the pyrolysis process can also result in the formation of derivatives containing oxygen, nitrogen, or sulfur, which may have higher toxicity than parent PAHs. The bioavailability of PAHs is an important parameter in the agricultural application of carbonaceous materials.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Babak Pourgholamali, Behnoush Sohrabi, Mandana Salbi, Sanaz Akbari, Iman Rastan, Masoud Sayaf, Abduladheem Turki Jalil, Mustafa M. Kadhim, Roghayeh Sheervalilou, Nazanin Mehrzad
Summary: Breast cancer is a leading cause of death among women and has both genetic and environmental factors. Analysis of miRNA expression profiles and target gene prediction identified miR-29c and miR-361 as potential prognostic biomarkers for breast cancer.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yin Li, Zhangkai Yang, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Bin Wu
Summary: In this study, alginate-coated CuS nanoparticles were synthesized as photothermal transforming agents to kill glioblastoma cancer cells. The nanoparticles showed high stability and monodispersity. In vitro investigations demonstrated that photothermal treatment based on CuS@Alg had a strong therapeutic impact.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Bin Jiang, Zhangkai Yang, Hangyu Shi, Abduladheem Turki Jalil, Marwan Mahmood Saleh, Weiyang Mi
Summary: Localized drug delivery vehicles based on implantable electrospun nanofibrous scaffolds have attracted interest in cancer cell eradication and tissue regeneration. In this study, zeolite Y nanoparticles were used to load Curcumin as an anticancer agent. The synthesized Curc@nZY was then integrated into a hybrid of PCL-gelatin electrospun nanofibers. The results showed successful loading of Curc@nZY into the nanofibers and a steady drug release over a long period.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Behnaz Naghshbandi, Mohammad Ali Omrani, Abolfazl Jafari-sales, Abduladheem Turki Jalil, Navid Naghsh
Summary: Monitoring the level of aflatoxin M1 (AFM1) in infant dried powder milk (IDPM) is crucial for ensuring the safety of dairy products consumed by Iranian infants. This study found that the average level of AFM1 in both imported and domestically produced IDPM samples was below the permissible limits set by the EU and Iranian national standards. However, the hazard quotient for infants below 6 months exceeded the allowable level, indicating the need for continuous monitoring of IDPM quality in Iranian markets.
JOURNAL OF FOOD PROTECTION
(2023)
Review
Environmental Sciences
Yasir Qasim Almajidi, Mustafa M. Kadhim, Fahad Alsaikhan, Abduladheem Turki Jalil, Nidhal Hassan Sayyid, Andres Alexis Ramirez-Coronel, Zanko Hassan Jawhar, Jitendra Gupta, Noushin Nabavi, Wei Yu, Yavuz Nuri Ertas
Summary: Nanomedicine is a field that combines biology and engineering to improve disease treatment, particularly in cancer therapy. Micelles, as a promising technique, have shown potential as nanocarriers for delivering chemotherapy drugs like Doxorubicin (DOX), and overcoming drug resistance mechanisms. This review highlights the potential of micelles in improving the targeted delivery and cytotoxicity of DOX, and discusses the challenges in employing chemotherapy to treat cancer.
ENVIRONMENTAL RESEARCH
(2023)
Article
Thermodynamics
Abduladheem Turki Jalil, Hayder Imad Jabar, Muataz Mohammed Al-Taee, Muhjaha Ahmed, Zahraa Khazal Hamdoon, Rahman S. Zabibah, Reza Shariyati
Summary: The perturbed hard-sphere chain (PHSC) equation of state (EOS) was used to predict the solubility of vitamins in mixed solvents. The solubilities of vitamins C, E, D3, K3, and B6H were studied at various solvents and temperatures. Model parameters were obtained using binary solubility experimental data, and the solubility of the vitamins in binary systems was predicted. The PHSC EOS demonstrated satisfactory performance in predicting vitamin solubility in mixed solvents.
FLUID PHASE EQUILIBRIA
(2023)
Article
Chemistry, Multidisciplinary
Indah Raya, Rosario Mireya Romero Parra, Ghulam Yasin, Abduladheem Turki Jalil, Khursheed Muzammil
Summary: In this study, Fe3O4@SiO2-Imine/Thio-Cu(II) nanomaterial was synthesized and its catalytic activity in the synthesis of N-aryl sulfonamides was investigated. The structure of the nanomaterial was characterized using various techniques. Recycling experiments showed that the nanocatalyst could be easily recovered and reused multiple times without loss of catalytic activity. The methodology offers several significant advantages including high reusability, simple recovery of catalyst, high yields, mild conditions, performance in water, and easy operation.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Review
Pathology
Abduladheem Turki Jalil, Mohanad Ali Abdulhadi, Lubna R. Al-Ameer, Hussein Abdullah Abbas, Muna. S. Merza, Rahman S. Zabibah, Ali A. Fadhil
Summary: MicroRNA-126 (miR-126) has diverse functions in cancer, affecting tumor angiogenesis, invasion, metastasis, cell proliferation, apoptosis, and treatment resistance. Dysregulation of miR-126 is associated with increased cancer risk and worse prognosis. Targeting miR-126 or its downstream effectors presents a potential therapeutic approach for inhibiting tumor development and combating drug resistance. Further investigation is needed to fully understand the mechanisms behind miR-126 dysregulation and develop efficient therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Hussein Riyadh Abdul Kareem Al-Hetty, Sada Jasim Abdulameer, Sami Awad Alkubaisy, Sawsan Ali Zaid, Abduladheem Turki Jalil, Ihsan Khudhair Jasim
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with a poor prognosis. Signal transducer and activator of transcription 3 (STAT3) plays a key role in the development of PDAC by promoting cell proliferation, survival, angiogenesis, and metastasis. Recent development of a selective potent chemical STAT3 inhibitor has shown promising therapeutic effects against PDAC in vitro and in vivo. This review aims to discuss the recent advances in understanding the role of STAT3 in PDAC pathogenesis and its potential as a therapeutic target.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Multidisciplinary Sciences
Athraa Y. Al-hijazi, Nada Hasan, Bassem Karim Nasr, Hanadi Hadi Jasim Al-Khafaji, Buthaina Al-Khafaji, Bahaa Fawzi Abdah Alanssari, Abduladheem Turki Jalil
Summary: Caries is a common chronic oral disease that can lead to secondary caries if traditional filling materials are used. Nanomaterials, such as inorganic nanoparticles, have shown potential in inhibiting biofilm formation, reducing demineralization, and promoting remineralization. Metal and metal oxide nanoparticles, particularly those releasing metal ions, have demonstrated significant antimicrobial activity. Fluoride-functionalized inorganic nanoparticles have also been employed to enhance their effectiveness by promoting remineralization and inhibiting demineralization. This review highlights the recent advances in using inorganic nanoparticles as anti-caries agents and discusses their antimicrobial, remineralizing, and mechanical impacts on dental materials.
Review
Oncology
Abduladheem Turki Jalil, Mohanad Ali Abdulhadi, Ahmed Mohsin Huran Al Jawadri, Hayder Abdullah Talib, Abdul Kareem J. Al-Azzawi, Rahman S. Zabibah, Ahmed Ali
Summary: Colorectal cancers are heterogeneous and contain cancer stem cells (CRCSCs) that play important roles in tumor development, metastasis, therapeutic resistance, and recurrence. Understanding the mechanisms of stemness in CRCSCs provides opportunities for new treatments or improved therapeutic regimens.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Genetics & Heredity
Ghufran Lutfi Ismaeel, Ali Hamid Abdul-Hussein, Hadeel Mohammed Qasim, Noor Kadhim Abed, Abduladheem Turki Jalil, Ahmed AbdulJabbar Suleiman, Saja Hussain Dilfy
Summary: This review discusses the generation of dormant cancer stem cells (CSCs) during tumor development, metastasis, therapy, and immune response. Dormancy determines the time gap between invasive CSCs' organotropism and the occurrence of macrometastasis. Dormancy allows CSCs to evade the immune system and therapeutic agents while supporting their survival and tumor recurrence in specific metastatic sites. The review also presents potential treatments targeting quiescence in CSCs based on their environmental dynamics to enhance cancer therapy outcomes.
Article
Medicine, Research & Experimental
Saade Abdalkareem Jasim, Omer Zedan Khalaf, Shadia Hamoud Alshahrani, Kadda Hachem, Shukhrat Ziyadullaev, Abduladheem Turki Jalil, ChangMing Wang, Rahman S. Zabibah, Yousef A. Bin Jardan, Qutaiba A. Qasim, Marwah Suliman Maashi, Yasser Fakri Mustafa
Summary: The study found that corosolic acid, a pentacyclic triterpenoid, has anti-cancer properties and can significantly inhibit cell proliferation and induce apoptosis in breast cancer cells. It was shown that corosolic acid induces apoptosis in triple-negative breast cancer cells by decreasing the phosphorylation levels of JAK2 and STAT3 proteins.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Biology
Mehdi Mohammadian Amiri, Yudi Garnida, Abbas F. Almulla, Ahmed Sami Abduljabbar, Abduladheem Turki Jalil, Yeganeh Mazaheri, Yahya Ebrahimi, Nabi Shariatifar
Summary: Hemorrhoids, a common rectal disease, have a significant impact on millions of people worldwide and result in numerous medical and socio-economic issues. This study aimed to investigate the effectiveness of medicinal plants in treating hemorrhoids. Various databases, including Google Scholar, SID, Scopus, PubMed, Science Direct, and WOS, were searched for articles containing the terms "medicinal plants" and "hemorrhoids" in their titles. The findings revealed that medicinal plants such as Aloe vera, Trigonella foenum-graecum L, Nigella sativa L, Curcuma longa L, Cocos nucifera L, Solanum nigrum L, Alhagi persarum Boiss & Buhse, Plantago lanceolata L, Achillea santolina, Malva neglecta Wallr, and Rubus fruticosus L exhibit anti-bleeding, analgesic, anti-inflammatory, and wound-healing properties, making them effective for treating hemorrhoids. The traditional Iranian edible plants investigated in this study contain various chemical compounds and provide specific health benefits for disease prevention and treatment.
ADVANCEMENTS IN LIFE SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Gufran Abd, Abduladheem Turki Jalil, Indrajit Patra, Samar Emad Izzat, Ngakan Ketut Acwin Dwijendra, Surendar Aravindhan, Mohamad Heydari Vini, Saeed Daneshmand
Summary: Employment of bi-metal laminates allows for better performance in properties such as light density, high strength, high corrosion and wear resistances. The study investigates the use of asymmetric roll bonding for the fabrication of bi-metal Al/Br laminates with thickness reduction ratios of 10-30%, and explores the effect of mismatch speed ratios through finite element simulation. Additionally, the bonding surface morphology of the samples was studied using SEM to improve bonding strength.
ACTA TECHNOLOGICA AGRICULTURAE
(2023)