Role of inositol polyphosphate-4-phosphatase type II in oncogenesis of digestive system tumors

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Expression and functional characterization of INPP4B in gallbladder cancer patients and gallbladder cancer cells

(2021) Youliang Wu et al.   BMC CANCER

INPP4B promotes colorectal cancer cell proliferation by activating mTORC1 signaling and cap-dependent translation

(2019) Xin-Hua Ruan et al.   OncoTargets and Therapy

INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma

(2019) Wendong Tang et al.   OncoTargets and Therapy

INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression

(2019) Liwen Yang et al.   CARCINOGENESIS

INPP4B As A Prognostic And Diagnostic Marker Regulates Cell Growth Of Pancreatic Cancer Via Activating AKT

(2019) Shuyu Zhai et al.   OncoTargets and Therapy

Inositol polyphosphate-4-phosphatase type II plays critical roles in the modulation of cadherin-mediated adhesion dynamics of pancreatic ductal adenocarcinomas

(2018) Bin Zhang et al.   Cell Adhesion & Migration

MiR-1290 Contributes to Colorectal Cancer Cell Proliferation by Targeting INPP4B

(2017) Qingzhu Ma et al.   ONCOLOGY RESEARCH

Mir-765 promotes cell proliferation by downregulating INPP4B expression in human hepatocellular carcinoma

(2016) Bin-Hui Xie et al.   Cancer Biomarkers

Inactivating Frameshift Mutation of INPP4B Encoding a PI3K Pathway Phosphatase in Gastric and Colorectal Cancers

(2016) Eun Ji Choi et al.   PATHOLOGY & ONCOLOGY RESEARCH

Inositol polyphosphate 4-phosphatase II (INPP4B) is associated with chemoresistance and poor outcome in AML

(2015) Sewa Rijal et al.   BLOOD

Update on Epstein-Barr virus and gastric cancer (Review)

(2015) AYA SHINOZAKI-USHIKU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

INPP4B overexpression is associated with poor clinical outcome and therapy resistance in acute myeloid leukemia

(2015) I Dzneladze et al.   LEUKEMIA

INPP4B is an oncogenic regulator in human colon cancer

(2015) S T Guo et al.   ONCOGENE

Phosphoinositide signaling in cancer: INPP4B Akt(s) out

(2015) John F. Woolley et al.   TRENDS IN MOLECULAR MEDICINE

INPP4B Is a Tumor Suppressor in the Context of PTEN Deficiency

(2015) T.-T. T. Vo et al.   Cancer Discovery

INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor

(2015) S. Kofuji et al.   Cancer Discovery

Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

(2015) Laura R. H. Ip et al.   Oncotarget

INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas

(2015) Meng Na Chi et al.   Oncotarget

INPP4B: the New Kid on the PI3K Block

(2015) Irina U. Agoulnik et al.   Oncotarget

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer

(2014) Jessica A. Gasser et al.   MOLECULAR CELL

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Epigenetic Inactivation of Inositol polyphosphate 4-phosphatase B (INPP4B), a Regulator of PI3K/AKT Signaling Pathway in EBV-Associated Nasopharyngeal Carcinoma

(2014) Jessie Wai-Fong Yuen et al.   PLoS One

Alterations of INPP4B, PIK3CA and pAkt of the PI3K pathway are associated with squamous cell carcinoma of the lung

(2014) Annika Stjernström et al.   Cancer Medicine

Phosphoinositide 3-kinase and INPP4B in human breast cancer

(2013) Micka C. Bertucci et al.   Annals of the New York Academy of Sciences

Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities

(2013) Sandra M. Lopez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells

(2013) Joong Won Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AKT-ing out: SGK kinases come to the fore: Figure 1

(2013) Larissa S. Moniz et al.   BIOCHEMICAL JOURNAL

Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells

(2012) Jae-Sung Kim et al.   CANCER BIOLOGY & THERAPY

Decreased Expression and Androgen Regulation of the Tumor Suppressor Gene INPP4B in Prostate Cancer

(2011) Myles C. Hodgson et al.   CANCER RESEARCH

PTEN Level in Tumor Suppression: How Much Is Too Little?

(2011) A. Carracedo et al.   CANCER RESEARCH

Contribution of Epithelial-to-Mesenchymal Transition and Cancer Stem Cells to Pancreatic Cancer Progression

(2011) Seth B. Krantz et al.   JOURNAL OF SURGICAL RESEARCH

Second AKT: The rise of SGK in cancer signalling

(2010) Maressa A. Bruhn et al.   GROWTH FACTORS

SGK3 Is an Estrogen-Inducible Kinase Promoting Estrogen-Mediated Survival of Breast Cancer Cells

(2010) Yuanzhong Wang et al.   MOLECULAR ENDOCRINOLOGY

Evidence that Inositol Polyphosphate 4-Phosphatase Type II Is a Tumor Suppressor that Inhibits PI3K Signaling

(2009) Christina Gewinner et al.   CANCER CELL

PI(3,4,5)P3 and PI(3,4)P2 levels correlate with PKB/akt phosphorylation at Thr308 and Ser473, respectively; PI(3,4)P2 levels determine PKB activity

(2007) Kewei Ma et al.   CELLULAR SIGNALLING