Article
Medical Laboratory Technology
Abdurrahman Coskun, Sverre Sandberg, Ibrahim Unsal, Coskun Cavusoglu, Mustafa Serteser, Meltem Kilercik, Aasne K. Aarsand
Summary: The study proposed a simple model to generate personalized reference intervals based on historical results, analytical and biological variation data. Increasing the number of measurements had little impact on the total variation around the true set point, and using >= 3 previous measurement results delivered robust personalized reference intervals.
CLINICAL CHEMISTRY
(2021)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Sverre Sandberg, Ibrahim Unsal, Fulya G. Yavuz, Coskun Cavusoglu, Mustafa Serteser, Meltem Kilercik, Aasne K. Aarsand
Summary: This study outlines statistical approaches and considerations for establishing and implementing personalized reference intervals (prRI) in clinical practice. Two different statistical models can be used to calculate prRI limits, based on within-person or within-subject biological variation estimates. prRI offers physicians the opportunity to improve interpretation of individuals' test results, though further studies are needed to demonstrate its impact on clinical outcomes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Medical Laboratory Technology
Kelly Doyle, Dustin R. Bunch
Summary: Clinical laboratory test results need clinically actionable cutoffs or reference intervals for result interpretation. Reference intervals have limitations, and new indirect methods are being explored to define personalized intervals. Standardized best practices and global collaborations are important for establishing accurate and personalized reference intervals.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Article
Medical Laboratory Technology
Sophie Stukas, Jennifer Cooper, Victoria Higgins, Daniel Holmes, Khosrow Adeli, Cheryl L. Wellington
Summary: Blood biomarkers have the potential to revolutionize diagnosis and prognosis for various neurological conditions. Normative data is crucial in the validation process, especially in children due to limited knowledge on how brain development impacts biomarkers. This study aimed to establish pediatric reference intervals for serum neurofilament light (NfL) and glial fibrillary acidic protein (GFAP).
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Taeyun Kim, Hyunji Choi, Sun Min Lee
Summary: This study aimed to establish reference intervals (RIs) for routine blood count and biochemistry tests using a large dataset of healthy, male Korean soldiers in their 20s. The RIs were compared using parametric and non-parametric estimation methods. The results showed that the RIs for hematological parameters were consistent between devices. Parametric and non-parametric methods were well-matched for Gaussian-distributed values, but the upper limits were higher with parametric methods for right-skewed values. Participants with obesity had higher RIs for certain blood count and liver function tests. Further studies are needed to determine RIs in different populations.
Review
Medical Laboratory Technology
Dan Yang, Zihan Su, Min Zhao
Summary: Although reference intervals are important in clinical diagnosis, there are significant differences in various factors. Traditional methods of establishing reference intervals have limitations, but the advent of big data offers a unique opportunity to establish specific reference intervals for clinical laboratories.
CLINICA CHIMICA ACTA
(2022)
Article
Computer Science, Interdisciplinary Applications
Murih Pusparum, Gokhan Ertaylan, Olivier Thas
Summary: The Population Reference Interval (PRI) is the expected range of outcomes in a healthy population for a clinical or diagnostic measurement, and it plays a crucial role in assisting clinical decision-making. This manuscript focuses on the calculation of Individual Reference Interval (IRI) and its combination with PRI to improve decision-making. The new methods proposed in this study show robustness and provide close empirical coverages to the nominal level.
JOURNAL OF BIOMEDICAL INFORMATICS
(2022)
Article
Multidisciplinary Sciences
Sylwia Placzkowska, Malgorzata Terpinska, Agnieszka Piwowar
Summary: This study aimed to determine reference intervals (RIs) for TSH and fT4 using the indirect Hoffman method and compare them with commonly used RIs. The results showed varying RIs in different age groups of the examined populations. The established RIs for fT4 were similar to the manufacturer and literature data, while RIs for TSH differed between age groups.
Article
Health Care Sciences & Services
Tobias Ueli Blatter, Harald Witte, Jules Fasquelle-Lopez, Jean Louis Raisaro, Alexander Benedikt Leichtle
Summary: This study describes the BioRef infrastructure, a multicentric governance and IT framework for estimating and assessing patient group-specific reference intervals (RIs) using routine clinical laboratory data and an innovative decentralized data-sharing approach.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Veterinary Sciences
Emma H. Hooijberg, Karin Lourens, Leith C. R. Meyer
Summary: This study established reference intervals for hematology and plasma clinical chemistry in Temminck's pangolins in southern Africa, which will help veterinarians determine health status, formulate optimal treatment plans, and increase patient survival rates in this endangered species. Differences were found between free-living and rehabilitated animals, likely due to variations in nutrition and hydration. These are the first reference intervals generated for Temminck's pangolins.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Medicine, General & Internal
Vid Bijelic, Beth Potter, Patricia C. Parkin, Franco Momoli, Mira Liebman, Jemila S. Hamid
Summary: Reference intervals and curves provide clinicians with a reference point for evaluating patients' laboratory test results. There have been large-scale initiatives to provide reference intervals and curves for children, but there is a lack of synthesized evidence regarding iron-related biomarkers. This review aims to identify studies that have produced reference intervals and curves for ferritin and hemoglobin in pediatric populations and to analyze the available evidence.
Article
Agriculture, Dairy & Animal Science
Jessica C. Whitham, Katie Hall, Lisa K. Lauderdale, Jocelyn L. Bryant, Lance J. Miller
Summary: In recent years, animal welfare scientists have focused on developing new methods to enhance the quality of life of chimpanzees living in zoos, sanctuaries, and laboratories. This study aimed to create reference intervals for behavioral measures and physiological biomarkers of chimpanzees, and found that these measures did not vary significantly by age or sex. The findings can help animal care professionals in making informed decisions regarding management and husbandry practices. Animal welfare researchers are dedicated to improving the lives of chimpanzees living in professional care through novel approaches.
Article
Oncology
Alexander Spira, Mark D. Stewart, Suzanne Jones, Elaine Chang, Anitra Fielding, Nicole Richie, Laura S. Wood, Michael A. Thompson, Lee Jones, Abhilasha Nair, Brandon A. Mahal, David E. Gerber
Summary: This study highlights the importance and impact of laboratory testing requirements in clinical research, and provides recommendations to optimize eligibility criteria, thereby increasing patient diversity and optimizing clinical data.
CLINICAL CANCER RESEARCH
(2021)
Article
Pediatrics
Christa Gernhold, Nina Kundtner, Martin Steinmair, Martin Henkel, Josef Oswald, Bernhard Haid
Summary: The study evaluated the effect of child-friendly measures on changing sedation rates. Results showed that by adjusting sedation policy, sedation rates were reduced from 27.1% to 7.5%, leading to improved patient satisfaction. Clear age limits, individual indication, and staff education were key in reducing the need for sedation.
Article
Health Care Sciences & Services
Wei Liu, Frank Bretz, Mario Cortina-Borja
Summary: Reference ranges are powerful tools for analyzing observations in clinical laboratories, aiming to classify atypical observations that may warrant further investigation. Some intervals, such as P prediction intervals, may not be suitable reference ranges as there is a substantial probability they contain less than (100 P)% of the population. In contrast, tolerance intervals designed to contain (100 P)% of the population with a large confidence gamma are more suitable as reference ranges.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2021)
Article
Medical Laboratory Technology
A. Leonard, T. Kyaw Tun, P. Gaffney, J. Sharma, J. Gibney, G. Boran
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2014)
Article
Medical Laboratory Technology
A. Leonard, G. Boran, A. Kane, M. Cornes
ANNALS OF CLINICAL BIOCHEMISTRY
(2020)
Article
Medicine, General & Internal
Ann Leonard, Brian Murray, Anna Rose Prior, Rama Srinivasan, Anne Kane, Gerard Boran
Summary: During the first wave of the COVID-19 pandemic, Ireland's Laboratory Medicine services showed an agile and resilient response, despite facing economic and staffing challenges.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Ann Leonard, Anna Rose Prior, Phyllis Reilly, Caroline Murray, Meghan O'Brien, Gillian Maguire, Deborah Ennis, Alex Reid, Ana Rakovac, Gerard Boran
Summary: This study reveals that a significant proportion of SARS-CoV-2 infections in healthcare workers may be asymptomatic or subclinical, potentially posing a significant transmission risk to colleagues and patients.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Public, Environmental & Occupational Health
M. Tempany, A. Leonard, A. R. Prior, G. Boran, P. Reilly, C. Murray, M. O'Brien, G. Maguire, D. Ennis, A. Rakovac, A. Reid
Summary: The study revealed a high prevalence of PCS among healthcare workers, even including some who were not previously diagnosed with COVID-19. The frequency and duration of PCS present challenges to employers in managing work availability and performance.
OCCUPATIONAL MEDICINE-OXFORD
(2021)
Article
Geriatrics & Gerontology
Adam H. Dyer, Claire Noonan, Matt McElheron, Isabella Batten, Conor Reddy, Emma Connolly, Rachel Pierpoint, Caroline Murray, Ann Leonard, Catriona Higgins, Phyllis Reilly, Gerard Boran, Thomas Phelan, William McCormack, Desmond O'Neill, Aoife Fallon, Gareth Brady, Cliona O'Farrelly, Nollaig M. Bourke, Sean P. Kennelly
Summary: In older nursing home residents, the history of SARS-CoV-2 infection is the strongest predictor of antibody titers at 6 months, while age and frailty are associated with lower titers. Antibody titers are significantly correlated with in vitro neutralization capacity.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Meeting Abstract
Geriatrics & Gerontology
A. Dyer, C. Noonan, C. Reddy, L. Garcia, I Batten, M. McElheron, N. Roche, E. Connolly, G. Boran, M. White, S. Pelleau, A. Leonard, D. O'Neill, A. Fallon, C. O'Farrelly, N. Bourke, S. Kennelly
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Leonard, A. Doolan, G. Boran, D. Burke, T. Moulton, M. Donnelly, C. Power, A. Rakovac
Meeting Abstract
Cardiac & Cardiovascular Systems
A. C. Leonard, S. R. S. Al Maqbali, E. Molloy, T. Bolger, G. Boran