Dipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration

The roles of CC chemokines in response to radiation

(2022) Lei Wang et al.   Radiation Oncology

Irradiated Tumor Cell-Derived Microparticles Prevent Lung Metastasis by Remodeling the Pulmonary Immune Microenvironment

(2022) Danyi Zhai et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Adaptive immune resistance at the tumour site: mechanisms and therapeutic opportunities

(2022) Tae Kon Kim et al.   NATURE REVIEWS DRUG DISCOVERY

The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment

(2022) Ze-Tao Zhan et al.   Journal of Immunology Research

Highly aneuploid non-small cell lung cancer shows enhanced responsiveness to concurrent radiation and immune checkpoint blockade

(2022) Liam F. Spurr et al.   Nature Cancer

DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts

(2021) Chien‐Kuo Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma

(2021) Allison A Fitzgerald et al.   Journal for ImmunoTherapy of Cancer

Targeting senescence-like fibroblasts radiosensitizes non–small cell lung cancer and reduces radiation-induced pulmonary fibrosis

(2021) Jingshu Meng et al.   JCI Insight

Dipeptidyl peptidase 4 inhibitors and their potential immune modulatory functions

(2020) Shiying Shao et al.   PHARMACOLOGY & THERAPEUTICS

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis

(2020) Xiao-Yong Huang et al.   Molecular Cancer

Irradiated tumor cell–derived microparticles mediate tumor eradication via cell killing and immune reprogramming

(2020) Chao Wan et al.   Science Advances

Turning “Cold” Into “Hot” Tumors—Opportunities and Challenges for Radio-Immunotherapy Against Primary and Metastatic Brain Cancers

(2019) Lisa Sevenich   Frontiers in Oncology

Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth

(2019) Clémence Hollande et al.   NATURE IMMUNOLOGY

Tumor-reprogrammed resident T cells resist radiation to control tumors

(2019) Ainhoa Arina et al.   Nature Communications

Inhibition of dipeptidyl peptidase IV prevents high fat diet-induced liver cancer angiogenesis by downregulating chemokine ligand 2

(2018) Chen-Jie Qin et al.   CANCER LETTERS

Inhibiting the CD8+ T cell infiltration in the tumor microenvironment after radiotherapy is an important mechanism of radioresistance

(2018) Hai-yan Chen et al.   Scientific Reports

Recent Developments in Radiotherapy

(2017) Deborah E. Citrin   NEW ENGLAND JOURNAL OF MEDICINE

Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells

(2017) Nils-Petter Rudqvist et al.   Cancer Immunology Research

Inhibition of DPP4 activity in humans establishes itsin vivorole in CXCL10 post‐translational modification: prospective placebo‐controlled clinical studies

(2016) Jérémie Decalf et al.   EMBO Molecular Medicine

Regulation of Chemokine Activity – A Focus on the Role of Dipeptidyl Peptidase IV/CD26

(2016) Mieke Metzemaekers et al.   Frontiers in Immunology

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE