Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 11, Pages 1277-1285Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1242000
Keywords
Boraginaceae; Echium confusum; pyrrolizidine alkaloids; 7-O-angeloyllycopsamine N-oxide; anti-AChE activity
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Funding
- Ministry of Higher Education and Scientific Research of Algeria [F02220120052]
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Four pyrrolizidine alkaloids, namely 7-O-angeloyllycopsamine N-oxide 1, echimidine N-oxide 2, echimidine 3 and 7-O-angeloylretronecine 4, were isolated for the first time from the whole plant ethanolic extract of Echium confusum Coincy, through bioassay-guided approach. Their structures were determined by spectroscopic means. All the isolates compounds showed moderate activities in inhibiting AChE, with IC50 0.276-0.769. [GRAPHICS]
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