Article
Medicine, General & Internal
Ancuta Elena Vijan, Ioana Cristina Daha, Caterina Delcea, Gheorghe-Andrei Dan
Summary: This study found that acute coronary syndromes, infections, heart failure, increased NT-proBNP levels, heart failure with reduced ejection fraction, and elevated HAS-BLED score were independent predictors of extended length of hospital stay in atrial fibrillation patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Athina Nasoufidou, Marianthi Kavelidou, Theodora Griva, Eleni Melikidou, Charalampos Maskalidis, Konstantina Machaira, Barbara Nikolaidou
Summary: This study aimed to assess the possible correlation between length of hospitalization (LOS) and clinical laboratory data of COVID-19 patients upon admission, including the total severity score (TSS) from chest computed tomography (CT). The results showed that LOS was associated with age and TSS, and the early identification of disease severity using TSS and patients' age could be useful for allocating inpatient resources and maintaining vigilance for those requiring long-term hospitalizations.
FRONTIERS IN MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Maamoun Basheer, Elias Saad, Dorin Shlezinger, Nimer Assy
Summary: This study examined the efficacy of convalescent plasma therapy on COVID-19 patients, demonstrating significant reduction in mortality and shorter hospitalization and time to negative PCR among moderate patients. Factors such as high BMI, elderly age, high CRP, and 4C-scores were found to correlate with disease severity and mortality. Convalescent plasma therapy also reduced inflammatory markers, especially in moderate COVID-19 patients.
Article
Biochemistry & Molecular Biology
Nick Andrews, Julia Stowe, Freja Kirsebom, Samuel Toffa, Ruchira Sachdeva, Charlotte Gower, Mary Ramsay, Jamie Lopez Bernal
Summary: This study examined the relative and absolute effectiveness of mRNA booster vaccination against COVID-19. The results showed that the booster dose of BNT162b2 or mRNA-1273 had a relative effectiveness ranging from 85% to 95% against symptomatic disease, and an absolute effectiveness ranging from 94% to 97%. For hospitalization or death, the absolute effectiveness of the BNT162b2 booster ranged from 97% to 99% in all age groups. The study provides real-world evidence of significantly increased protection from the booster vaccine dose against mild and severe disease.
Article
Medicine, General & Internal
Egle Ignataviciute, Diana Zaliaduonyte, Vytautas Zabiela
Summary: This study aimed to evaluate the factors influencing the length of in-hospital stay in heart failure patients. The results revealed that treatment interruption, higher NT-proBNP value, eGFR=50 mL/min/1.73 m(2), systolic BP=135 mmHg, and severe tricuspid valve regurgitation were identified as independent factors associated with prolonged hospitalization. These findings have important implications for managing the length of in-hospital stay in heart failure patients.
MEDICINA-LITHUANIA
(2023)
Article
Clinical Neurology
Gina S. Perez S. Giraldo, Sareen T. Ali, Anthony K. Kang, Tulsi R. Patel, Shreya Budhiraja, Jordan I. Gaelen, Grace K. Lank, Jeffrey R. Clark, Shreya Mukherjee, Tracey Singer, Aditi Venkatesh, Zachary S. Orban, Patrick H. Lim, Millenia Jimenez, Janet Miller, Carolyn Taylor, April L. Szymanski, Jessica Scarpelli, Edith L. Graham, Roumen D. Balabanov, Bianca E. Barcelo, Joshua G. Cahan, Kaitlyn Ruckman, Alan G. Shepard, Marc W. Slutzky, Kathrin LaFaver, Priya U. Kumthekar, Neil K. Shetty, Katherine S. Carroll, Sam U. Ho, Rimas V. Lukas, Ayush Batra, Eric M. Liotta, Igor J. Koralnik
Summary: This study characterizes the neurological manifestations in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients. PNP patients were older and had more comorbidities compared to NNP patients. PNP patients had a higher rate of abnormal neurological exams and worse cognitive performance compared to NNP patients.
ANNALS OF NEUROLOGY
(2023)
Article
Medical Laboratory Technology
Alexander H. Cotter, Su-Jau T. Yang, Hedyeh Shafi, Timothy M. Cotter, Darryl Erik Palmer-Toy
Summary: The study found that coagulation factor and endothelial injury marker, von Willebrand factor antigen (vWF:Ag), are elevated in COVID-19 inpatients, and are associated with adverse clinical outcomes and prolonged length of stay.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Medicine, General & Internal
Maan El Halabi, James Feghali, Jeeyune Bahk, Paulino Tallon de Lara, Bharat Narasimhan, Kam Ho, Mantej Sehmbhi, Joseph Saabiye, Judy Huang, Georgina Osorio, Joseph Mathew, Juan Wisnivesky, David Steiger
Summary: This study developed a web-based calculator to predict hospitalization and length of stay in COVID-19-positive patients presenting to the Emergency Department. The predictive models showed good discrimination and identified several key predictors such as age, chronic kidney disease, fever, and oxygen desaturation. Elevated levels of CRP, creatinine, and ferritin were also found to be important determinants.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Medicine, General & Internal
Cenk Babayigit, Nurdan Kokturk, Seval Kul, Pelin Duru Cetinkaya, Sibel Atis Nayci, Serap Argun Baris, Oguz Karcioglu, Pinar Aysert, Ilim Irmak, Aycan Akbas Yuksel, Yonca Sekibag, Oya Baydar Toprak, Emel Azak, Sait Mulamahmutoglu, Caglar Cuhadaroglu, Aslihan Demirel, Bugra Kerget, Burcu Baran Ketencioglu, Hasan Selcuk Ozger, Gulcihan Ozkan, Zeynep Ture, Begum Ergan, Vildan Avkan Oguz, Oguz Kilinc, Merve Ercelik, Tansu Ulukavak Ciftci, Ozlem Alici, Esra Nurlu Temel, Ozlem Ataoglu, Asena Aydin, Dilek Cetiner Bahcetepe, Yusuf Taha Gullu, Fusun Fakili, Figen Deveci, Neslihan Kose, Muge Meltem Tor, Gulsah Gunluoglu, Sedat Altin, Teyfik Turgut, Tibel Tuna, Onder Ozturk, Oner Dikensoy, Pinar Yildiz Gulhan, Ilknur Basyigit, Hasim Boyaci, Ipek Kivilcim Oguzulgen, Sermin Borekci, Bilun Gemicioglu, Firat Bayraktar, Osman Elbek, Ismail Hanta, Hacer Kuzu Okur, Gulseren Sagcan, Oguz Uzun, Metin Akgun, Goksel Altinisik, Berna Dursun, Ebru Cakir Edis, Erkmen Gulhan, Fusun Oner Eyuboglu, Okkes Gultekin, Yavuz Havlucu, Metin Ozkan, Aysin Coskun, Abdullah Sayiner, A. Fuat Kalyoncu, Oya Itil, Hasan Bayram
Summary: This study investigated the association of repurposed antiviral drugs with COVID-19 morbidity. The findings demonstrated that antiviral drugs such as lopinavir, ritonavir, and favipiravir were associated with negative clinical outcomes in COVID-19 patients.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Manish Sagar, Katherine Reifler, Michael Rossi, Nancy S. Miller, Pranay Sinha, Laura F. White, Joseph P. Mizgerd
Summary: The study suggests that individuals with prior endemic coronavirus infections were tested more frequently for respiratory infections, but had similar rates of acquiring SARS-CoV-2. Additionally, patients with previous endemic coronavirus infections experienced less severe cases of COVID-19.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Environmental Sciences
Jin Feng, Dawei Cao, Dashan Zheng, Zhengmin (Min) Qian, Cunrui Huang, Huiqing Shen, Yi Liu, Qiyong Liu, Jimin Sun, Guangyuan Jiao, Xiaoran Yang, Stephen Edward McMillin, Chongjian Wang, Hualiang Lin, Xinri Zhang, Shiyu Zhang
Summary: This study found significant associations between cold spells and hospital admissions, length of hospital stay, and hospitalization expenses for respiratory diseases. Compared with the non-cold spell period, the overall cumulative risk of hospitalization for total respiratory diseases on cold spell days was 1.232 (95% CI: 1.090, 1.394), with increased length of hospital stay and hospitalization expenses of 112.793 (95% CI: 10.755, 214.830) days and 127.568 (95% CI: 40.513, 214.624) thousand Chinese yuan, respectively. The cumulative risks of cold spells on total respiratory diseases and pneumonia were statistically significant. Harvesting effects were also observed in the associations between cold spells and hospital admission, length of hospital stay, and hospitalization expenses for respiratory diseases.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Editorial Material
Medicine, Research & Experimental
Philip A. Mudd, Kenneth E. Remy
Summary: Observational clinical research has highlighted the immune response to SARS-CoV-2 during the COVID-19 pandemic, indicating that immune dysregulation and prolonged adaptive immune system activation can lead to cellular exhaustion. A recent study compared cellular immune phenotypes in hospitalized and non-hospitalized COVID-19 patients, revealing consistent activation and cellular exhaustion in both groups. Follow-up samples from non-hospitalized patients showed increasing activation markers and cellular exhaustion over time, suggesting potential long-term effects on immunity maintenance to SARS-CoV-2.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Psychiatry
Pawel Gosek, Justyna Kotowska, Elzbieta Rowinska-Garbien, Dariusz Bartczak, Janusz Heitzman
Summary: Patients with schizophrenia spectrum disorders represent the largest group of forensic inpatients worldwide. Factors such as mental disorders among family members, alcohol or substance dependence, severity of criminal behavior, and treatment resistance affect the length of stay in forensic hospitals.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
Cheng-Chang Yang, Oluwaseun Adebayo Bamodu, Lung Chan, Jia-Hung Chen, Chien-Tai Hong, Yi-Ting Huang, Chen-Chih Chung
Summary: This study developed an artificial neural network model to predict prolonged length of hospital stay after acute ischemic stroke by identifying risk factors and using parameters at the time of hospitalization. The key factors associated with prolonged length of stay included National Institutes of Health Stroke Scale scores at admission, atrial fibrillation, receiving thrombolytic therapy, history of hypertension, diabetes, and previous stroke. The proposed model can assist in clinically assessing the risk of prolonged hospitalization, informing decision-making, and developing individualized medical care plans for patients with acute ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Infectious Diseases
Alma Trnacevic, Amer Mujkanovic, Noura Al-Salloum, Amra Sakusic, Emir Trnacevic, Emir Jusufovic, Fatima Hukic, Rahima Jahic, Richard Stratton
Summary: This study analyzed the data of the first cohort of COVID-19 patients in B&H, finding that factors such as BMI greater than 25, comorbidities, elevated creatinine, and O2 saturation less than 95% may lead to prolonged hospitalization. Furthermore, the risk factors for COVID-19 patients in B&H do not differ from those reported in other countries.
BMC INFECTIOUS DISEASES
(2021)
