What Have We Learned by Resurrecting the 1918 Influenza Virus?

Newly Emerging Strategies in Antiviral Drug Discovery: Dedicated to Prof. Dr. Erik De Clercq on Occasion of His 80th Anniversary

(2022) Shujing Xu et al.   MOLECULES

Archival influenza virus genomes from Europe reveal genomic variability during the 1918 pandemic

(2022) Livia V. Patrono et al.   Nature Communications

Generation of a live attenuated influenza A vaccine by proteolysis targeting

(2022) Longlong Si et al.   NATURE BIOTECHNOLOGY

Has Epizootic Become Enzootic? Evidence for a Fundamental Change in the Infection Dynamics of Highly Pathogenic Avian Influenza in Europe, 2021

(2022) Anne Pohlmann et al.   mBio

Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021

(2022) V. Caliendo et al.   Scientific Reports

Global dissemination of H5N1 influenza viruses bearing the clade 2.3.4.4b HA gene and biologic analysis of the ones detected in China

(2022) Pengfei Cui et al.   Emerging Microbes & Infections

Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

(2022) Qing Xiong et al.   NATURE

Alarming situation of emerging H5 and H7 avian influenza and effective control strategies

(2022) Jianzhong Shi et al.   Emerging Microbes & Infections

A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

(2021) Xianwen Zhang et al.   CELL

Engineering SARS-CoV-2 using a reverse genetic system

(2021) Xuping Xie et al.   Nature Protocols

Establishment of a reverse genetics system for SARS-CoV-2 using circular polymerase extension reaction

(2021) Shiho Torii et al.   Cell Reports

Development of a New Reverse Genetics System for Ebola Virus

(2021) Tianyu Gan et al.   mSphere

Antiviral Drug Delivery System for Enhanced Bioactivity, Better Metabolism and Pharmacokinetic Characteristics

(2021) Ran Chen et al.   International Journal of Nanomedicine

A versatile reverse genetics platform for SARS-CoV-2 and other positive-strand RNA viruses

(2021) Alberto A. Amarilla et al.   Nature Communications

Rapid assessment of SARS-CoV-2–evolved variants using virus-like particles

(2021) Abdullah M. Syed et al.   SCIENCE

Small-molecule targeted recruitment of a nuclease to cleave an oncogenic RNA in a mouse model of metastatic cancer

(2020) Matthew G. Costales et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

(2020) Tran Thi Nhu Thao et al.   NATURE

Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays

(2020) Katharine H. D. Crawford et al.   Viruses-Basel

Spike mutation D614G alters SARS-CoV-2 fitness

(2020) Jessica A. Plante et al.   NATURE

Rescue of SARS-CoV-2 from a Single Bacterial Artificial Chromosome

(2020) Chengjin Ye et al.   mBio

Fifty Years in Search of Selective Antiviral Drugs

(2019) Erik De Clercq   JOURNAL OF MEDICINAL CHEMISTRY

1918 H1N1 Influenza Virus Replicates and Induces Proinflammatory Cytokine Responses in Extrarespiratory Tissues of Ferrets

(2018) Emmie de Wit et al.   JOURNAL OF INFECTIOUS DISEASES

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study

(2018) A Danielle Iuliano et al.   LANCET

Angels and Devils: Dilemmas in Dual-Use Biotechnology

(2018) Landon J. Getz et al.   TRENDS IN BIOTECHNOLOGY

Influenza

(2017) Catharine Paules et al.   LANCET

Entirely plasmid-based reverse genetics system for rotaviruses

(2017) Yuta Kanai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced protein degradation: an emerging drug discovery paradigm

(2016) Ashton C. Lai et al.   NATURE REVIEWS DRUG DISCOVERY

Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies

(2015) Renato A. Bauer   DRUG DISCOVERY TODAY

An Improved Reverse Genetics System to Overcome Cell-Type–Dependent Ebola Virus Genome Plasticity

(2015) Yoshimi Tsuda et al.   JOURNAL OF INFECTIOUS DISEASES

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Multidrug resistant tuberculosis

(2015) J. Millard et al.   BMJ-British Medical Journal

Multidrug resistant tuberculosis

(2015) J. Millard et al.   BMJ-British Medical Journal

A Live Attenuated Influenza A(H5N1) Vaccine Induces Long-Term Immunity in the Absence of a Primary Antibody Response

(2014) Kawsar R. Talaat et al.   JOURNAL OF INFECTIOUS DISEASES

Airborne Transmission of Highly Pathogenic H7N1 Influenza Virus in Ferrets

(2014) T. C. Sutton et al.   JOURNAL OF VIROLOGY

Avian influenza vaccines against H5N1 ‘bird flu’

(2014) Chengjun Li et al.   TRENDS IN BIOTECHNOLOGY

Structural Determinants for Naturally Evolving H5N1 Hemagglutinin to Switch Its Receptor Specificity

(2013) Kannan Tharakaraman et al.   CELL

Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments

(2013) Simon Wain-Hobson   EMBO Molecular Medicine

Influenza-Induced Inflammation Drives Pneumococcal Otitis Media

(2013) Kirsty R. Short et al.   INFECTION AND IMMUNITY

Mutations in haemagglutinin that affect receptor binding and pH stability increase replication of a PR8 influenza virus with H5 HA in the upper respiratory tract of ferrets and may contribute to transmissibility

(2013) H. Shelton et al.   JOURNAL OF GENERAL VIROLOGY

A New Determinant of H5N1 Influenza Virus Pathogenesis in Mammals

(2013) T. S. Dermody et al.   JOURNAL OF VIROLOGY

The pH of Activation of the Hemagglutinin Protein Regulates H5N1 Influenza Virus Replication and Pathogenesis in Mice

(2013) H. Zaraket et al.   JOURNAL OF VIROLOGY

Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation

(2013) Bart L Haagmans et al.   LANCET INFECTIOUS DISEASES

Limited airborne transmission of H7N9 influenza A virus between ferrets

(2013) Mathilde Richard et al.   NATURE

Pandemic Influenza Viruses — Hoping for the Road Not Taken

(2013) David M. Morens et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

H5N1 Hybrid Viruses Bearing 2009/H1N1 Virus Genes Transmit in Guinea Pigs by Respiratory Droplet

(2013) Y. Zhang et al.   SCIENCE

Engineering a Replication-Competent, Propagation-Defective Middle East Respiratory Syndrome Coronavirus as a Vaccine Candidate

(2013) F. Almazan et al.   mBio

Stability-mediated epistasis constrains the evolution of an influenza protein

(2013) Lizhi Ian Gong et al.   eLife

Influenza-Associated Pneumonia Among Hospitalized Patients With 2009 Pandemic Influenza A (H1N1) Virus--United States, 2009

(2012) S. Jain et al.   CLINICAL INFECTIOUS DISEASES

Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?

(2012) Kirsty R Short et al.   Future Microbiology

Age- and Sex-Specific Mortality Associated With the 1918–1919 Influenza Pandemic in Kentucky

(2012) Cécile Viboud et al.   JOURNAL OF INFECTIOUS DISEASES

The Multibasic Cleavage Site in H5N1 Virus Is Critical for Systemic Spread along the Olfactory and Hematogenous Routes in Ferrets

(2012) E. J. A. Schrauwen et al.   JOURNAL OF VIROLOGY

A Novel Bacterium-Free Method for Generation of Flavivirus Infectious DNA by Circular Polymerase Extension Reaction Allows Accurate Recapitulation of Viral Heterogeneity

(2012) J. Edmonds et al.   JOURNAL OF VIROLOGY

Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

(2012) Masaki Imai et al.   NATURE

Comparison of Temporal and Spatial Dynamics of Seasonal H3N2, Pandemic H1N1 and Highly Pathogenic Avian Influenza H5N1 Virus Infections in Ferrets

(2012) Judith M. A. van den Brand et al.   PLoS One

An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response

(2012) B. W. Jagger et al.   SCIENCE

Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets

(2012) S. Herfst et al.   SCIENCE

Increased Nasopharyngeal Bacterial Titers and Local Inflammation Facilitate Transmission of Streptococcus pneumoniae

(2012) K. R. Short et al.   mBio

Entry of Human Papillomavirus Type 16 by Actin-Dependent, Clathrin- and Lipid Raft-Independent Endocytosis

(2012) Mario Schelhaas et al.   PLoS Pathogens

Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function

(2011) Yuet Wu et al.   BMC INFECTIOUS DISEASES

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

The Multibasic Cleavage Site of the Hemagglutinin of Highly Pathogenic A/Vietnam/1203/2004 (H5N1) Avian Influenza Virus Acts as a Virulence Factor in a Host-Specific Manner in Mammals

(2011) A. L. Suguitan et al.   JOURNAL OF VIROLOGY

A Vesicular Stomatitis Virus Replicon-Based Bioassay for the Rapid and Sensitive Determination of Multi-Species Type I Interferon

(2011) Marianne Berger Rentsch et al.   PLoS One

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses

(2011) Taronna R. Maines et al.   VIROLOGY

Lethal Synergism of 2009 Pandemic H1N1 Influenza Virus and Streptococcus pneumoniae Coinfection Is Associated with Loss of Murine Lung Repair Responses

(2011) J. C. Kash et al.   mBio

Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

(2011) Sergey Kryazhimskiy et al.   PLoS Genetics

Dissection of the Influenza A Virus Endocytic Routes Reveals Macropinocytosis as an Alternative Entry Pathway

(2011) Erik de Vries et al.   PLoS Pathogens

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

(2010) Dimitri A. Diavatopoulos et al.   FASEB JOURNAL

Postinfluenza Bacterial Pneumonia: Host Defenses Gone Awry

(2010) Megan N. Ballinger et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Receptor Binding Profiles of Avian Influenza Virus Hemagglutinin Subtypes on Human Cells as a Predictor of Pandemic Potential

(2010) H. Shelton et al.   JOURNAL OF VIROLOGY

Ebolavirus Is Internalized into Host Cells via Macropinocytosis in a Viral Glycoprotein-Dependent Manner

(2010) Asuka Nanbo et al.   PLoS Pathogens

HIV Enters Cells via Endocytosis and Dynamin-Dependent Fusion with Endosomes

(2009) Kosuke Miyauchi et al.   CELL

Important Science--It's All about the SPIN

(2009) A. Casadevall et al.   INFECTION AND IMMUNITY

Neuraminidase Stalk Length and Additional Glycosylation of the Hemagglutinin Influence the Virulence of Influenza H5N1 Viruses for Mice

(2009) Y. Matsuoka et al.   JOURNAL OF VIROLOGY

Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus

(2009) H. M. Weingartl et al.   JOURNAL OF VIROLOGY

Synthetic viruses: a new opportunity to understand and prevent viral disease

(2009) Eckard Wimmer et al.   NATURE BIOTECHNOLOGY

Bacterial Pathogens and Death during the 1918 Influenza Pandemic

(2009) Yu-Wen Chien et al.   NEW ENGLAND JOURNAL OF MEDICINE

2009 Swine-Origin Influenza A (H1N1) Resembles Previous Influenza Isolates

(2009) Carl Kingsford et al.   PLoS One

Evaluation of two live attenuated cold-adapted H5N1 influenza virus vaccines in healthy adults

(2009) Ruth A. Karron et al.   VACCINE

An early ‘classical’ swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice

(2009) Matthew J. Memoli et al.   VIROLOGY

Pandemic and seasonal influenza: therapeutic challenges

(2008) Matthew J. Memoli et al.   DRUG DISCOVERY TODAY

Predominant Role of Bacterial Pneumonia as a Cause of Death in Pandemic Influenza: Implications for Pandemic Influenza Preparedness

(2008) David M. Morens et al.   JOURNAL OF INFECTIOUS DISEASES

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

(2008) C. Pappas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets

(2008) T. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA