Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

(2023) Dirk Jochmans et al.   mBio

Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors

(2023) Seyed Arad Moghadasi et al.   Science Advances

Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2

(2022) Lihong Liu et al.   NATURE

Nirmatrelvir Plus Ritonavir: First Approval

(2022) Yvette N. Lamb   DRUGS

Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19

(2022) Yuto Unoh et al.   JOURNAL OF MEDICINAL CHEMISTRY

S-217622, a 3CL Protease Inhibitor and Clinical Candidate for SARS-CoV-2

(2022) Joel D. A. Tyndall   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetics of Oral Nirmatrelvir/Ritonavir, a Protease Inhibitor for Treatment of COVID ‐19, in Subjects With Renal Impairment

(2022) Sima S. Toussi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance

(2022) Ala M. Shaqra et al.   Nature Communications

Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

(2022) Julia M Flynn et al.   eLife

SARS-CoV-2 3CL pro mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376

(2022) Emmanuel Heilmann et al.   Science Translational Medicine

Multiple pathways for SARS-CoV-2 resistance to nirmatrelvir

(2022) Sho Iketani et al.   NATURE

Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system

(2022) Yuyong Zhou et al.   Science Advances

Prospective mapping of viral mutations that escape antibodies used to treat COVID-19

(2021) Tyler N. Starr et al.   SCIENCE

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

(2021) Pengfei Wang et al.   NATURE

Introduction: Drug Resistance

(2021) Nese Kurt Yilmaz et al.   CHEMICAL REVIEWS

A tale of two antiviral targets — and the COVID-19 drugs that bind them

(2021) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients

(2021) Angélica Jayk Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

(2021) Dafydd R. Owen et al.   SCIENCE

Analyses of HIV proteases variants at the threshold of viability reveals relationships between processing efficiency and fitness

(2021) Gily Schneider-Nachum et al.   Virus Evolution

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

(2020) Robert L. Hoffman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Point mutation bias in SARS-CoV-2 variants results in increased ability to stimulate inflammatory responses

(2020) Masato Kosuge et al.   Scientific Reports

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19

(2020) Peter Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Consensus sequence design as a general strategy to create hyperstable, biologically active proteins

(2019) Matt Sternke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elucidating the Interdependence of Drug Resistance from Combinations of Mutations

(2017) Debra A. Ragland et al.   Journal of Chemical Theory and Computation

CRISPR-Cas9–mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy

(2017) Leyuan Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improving Viral Protease Inhibitors to Counter Drug Resistance

(2016) Nese Kurt Yilmaz et al.   TRENDS IN MICROBIOLOGY

Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae

(2014) Diana S.M. Ottoz et al.   NUCLEIC ACIDS RESEARCH

Strong evidence for protein epistasis, weak evidence against it

(2014) D. D. Pollock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Resistance to vemurafenib resulting from a novel mutation in the BRAFV600E kinase domain

(2013) Timothy R. Wagenaar et al.   Pigment Cell & Melanoma Research

Molecular Mechanisms of Viral and Host Cell Substrate Recognition by Hepatitis C Virus NS3/4A Protease

(2011) K. P. Romano et al.   JOURNAL OF VIROLOGY

Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection

(2011) Yo Suzuki et al.   NATURE METHODS

Community Transmission of Oseltamivir-Resistant A(H1N1)pdm09 Influenza

(2011) Aeron C. Hurt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Permissive Neuraminidase Mutations in Influenza A/Brisbane/59/2007-like (H1N1) Viruses

(2011) Yacine Abed et al.   PLoS Pathogens

Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease

(2010) Shu-Chun Cheng et al.   BIOPHYSICAL JOURNAL

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

(2010) M. N. L. Nalam et al.   JOURNAL OF VIROLOGY

Molecular Basis for Drug Resistance in HIV-1 Protease

(2010) Akbar Ali et al.   Viruses-Basel

Mechanism for Controlling the Dimer-Monomer Switch and Coupling Dimerization to Catalysis of the Severe Acute Respiratory Syndrome Coronavirus 3C-Like Protease

(2008) J. Shi et al.   JOURNAL OF VIROLOGY