Journal
NANOTECHNOLOGY
Volume 27, Issue 29, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/27/29/295101
Keywords
localized surface plasmon resonance; Fabry-Perot cavity mode; nanoimprint lithography; cell concentration detection; quasi 3D plasmonic nanostructure
Funding
- Center for Biosystems, Neuroscience, and Nanotechnology (CBNN) of City University of Hong Kong [9360148]
- University Grants Council of Hong Kong [120413, 11210814]
- City University of Hong Kong [9380062]
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Quasi three-dimensional (3D) plasmonic nanostructures consisting of Au nanosquares on top of SU-8 nanopillars and Au nanoholes on the bottom were developed and fabricated using nanoimprint lithography with simultaneous thermal and UV exposure. These 3D plasmonic nanostructures were used to detect cell concentration of lung cancer A549 cells, retinal pigment epithelial (RPE) cells, and breast cancer MCF-7 cells. Nanoimprint technology has the advantage of producing high uniformity plasmonic nanostructures for such biosensors. Multiple resonance modes were observed in these quasi 3D plasmonic nanostructures. The hybrid coupling of localized surface plasmon resonances and Fabry-Perot cavity modes in the quasi 3D nanostructures resulted in high sensitivity of 496 nm/refractive index unit. The plasmonic resonance peak wavelength and sensitivity could be tuned by varying the Au thickness. Resonance peak shifts for different cells at the same concentration were distinct due to their different cell area and confluency. The cell concentration detection limit covered a large range of 5 x 10(2) to 1 x 10(7) cells ml(-1) with these new plasmonic nanostructures. They also provide a large resonance peak shift of 51 nm for as little as 0.08 cells mm(-2) of RPE cells for high sensitivity cell detection.
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