Journal
NANOSCALE
Volume 8, Issue 5, Pages 2960-2966Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr07808c
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Funding
- Natural Science Foundation of China [21234004, 21420102007, 21574056, 21221063, 21474038]
- Chang Jiang Scholars Program of China
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An anion transporter with a selenoxide group was able to form nanoparticles in water, whose activity was fully turned off due to the aggregation effect. The formed nanoparticles have a uniform size and can be readily dispersed in water at high concentrations. Turn-on of the nanoparticles by reducing molecules is proposed to be a combined process, including the reduction of selenoxide to selenide, disassembly of the nanoparticles and location of the transporter to the lipid membrane. Accordingly, a special acceleration phase can be observed in the turn-on kinetic curves. Since turn-on of the nanoparticles is quantitatively related to the amount of reductant, the nanoparticles can be activated in a step-by-step manner. Due to the sensibility of this system to thiols, cysteine can be detected at low nanomolar concentrations. This ultra-sensitive thiol-responsive transmembrane anion transport system is quite promising in biological applications.
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