Article
Clinical Neurology
Jirada Sringean, Ambra Stefani, Kathrin Marini, Melanie Bergmann, Mario Werkmann, Evi Holzknecht, Roberto De Marzi, Elisabeth Brandauer, Heinz Hackner, Atbin Djamshidian, Heike Stockner, Carles Gaig, Alex Iranzo, Joan Santamaria, Eduardo Tolosa, Klaus Seppi, Werner Poewe, Birgit Hoegl
Summary: The study found that early-stage PD patients had shorter REM sleep latency compared to advanced-stage PD patients. In advanced-stage PD patients, there was a higher incidence and intensity of rapid eye movement (REM) sleep without atonia (RWA), indicating that RWA worsens or becomes more intense with disease progression.
Review
Clinical Neurology
Jung-Ick Byun, Tae-Won Yang, Jun-Sang Sunwoo, Won Chul Shin, Oh-Young Kwon, Ki-Young Jung
Summary: Manual quantification of rapid eye movement (REM) sleep without atonia (RWA) using chin or phasic flexor digitorum superficialis (FDS) activity shows the best diagnostic performance for REM sleep behavior disorder (RBD). The automatic REM atonia index (RAI) method may be useful for screening RBD patients.
Review
Clinical Neurology
Fabian Cavalloni, Ines Debove, M. Lenard Lachenmayer, Paul Krack, Claudio Pollo, W. M. Michael Schuepbach, Claudio L. A. Bassetti, Panagiotis Bargiotas
Summary: REM-sleep behavior disorder (RBD) is a common sleep issue in Parkinson's disease, and the impact of deep brain stimulation (DBS) on RBD remains limited and controversial. Studies suggest that different DBS targets may lead to varying changes in sleep behaviors, highlighting the need for more large-scale, prospective, controlled studies for further exploration.
Article
Clinical Neurology
Femke Dijkstra, Nathan Reyn, Barbara de Bruyn, Karlien van den Bossche, Ilse de Volder, Marc Willemen, Mineke Viaene, Jo Leenders, Patrick Cras, David Crosiers
Summary: The study found that in the prodromal stages of Parkinson's disease (PD), patients showed higher RSWA variables and a higher percentage of nocturnal supine body position, regardless of RBD status. These results suggest that these PSG abnormalities may serve as prodromal biomarkers for PD.
Article
Clinical Neurology
Utku Ogan Akyildiz, F. Irsel Tezer, Guray Koc, Sevda Ismailogullari, Aylin Bican Demir, Aysin Kisabay Ak, Gulin Sunter, Kezban Aslan Kara, Deniz Tuncel Berktas, Aysenur Sahin, Filiz Azman, Bulent Devrim Akcay, Duygu Kurt Gok, Hikmet Yilmaz, Kadriye Agan, Yavuz Bekmezci, Sinan Yetkin, Murat Aksu, Derya Karadeniz, Gulcin Benbir Senel
Summary: This study aimed to evaluate the characteristics of REM sleep in patients with narcolepsy. The results showed that the increase in REM density during REM sleep may be a major correlate of RSWA. There was a positive correlation between the total duration of REMs and the mean durations of RSWA. The REMs index demonstrated moderate sensitivity and specificity in the diagnosis of RSWA.
Article
Clinical Neurology
Wei-Ye Xie, Yun Shen, Ying Chen, Sheng Zhuang, Ya-Li Wang, Hong Jin, Han-Xing Li, Jia-Hui Yan, Ying Li, Cheng-Jie Mao, Yong-Ping Dai, Chun-Feng Liu
Summary: This study aims to investigate the association between brainstem neuronal pathway dysfunction and the onset of rapid eye movement (REM) sleep behavior disorder (RBD) in patients with early-stage Parkinson's disease (PD) and isolated RBD (iRBD). The results suggest that changes in vestibular-evoked myogenic potentials (VEMPs) parameters are associated with REM sleep without atonia (RSWA) in PD patients, highlighting the significance of detecting brainstem dysfunction in early-stage PD.
Article
Clinical Neurology
Adeel A. Memon, Corina Catiul, Zachary Irwin, Jennifer Pilkington, Raima A. Memon, Allen Joop, Kimberly H. Wood, Gary Cutter, Svjetlana Miocinovic, Amy W. Amara
Summary: PD patients with RBD have altered sleep-related qEEG compared to those without RBD. Lower sleep spindle density, rather than the presence of RBD, predicts worse comprehensive cognitive score. Future studies should explore the association between sleep-related qEEG alterations and cognitive decline in PD-RBD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
John C. Feemster, Tyler A. Steele, Kyle P. Palermo, Christy L. Ralston, Yumeng Tao, David A. Bauer, Liam Edgar, Sonia Rivera, Maxwell Walters-Smith, Thomas R. Gossard, Luke N. Teigen, Paul C. Timm, Jarrett W. Richardson, R. Robert Auger, Bhanuprakash Kolla, Stuart J. McCarter, Bradley F. Boeve, Michael H. Silber, Erik K. St Louis
Summary: This study comparatively analyzed REM sleep without atonia (RSWA) in chronic PTSD patients with and without dream enactment behavior (DEB), isolated RBD patients, and controls. The results show that PTSD patients have higher RSWA than controls, indicating abnormal REM sleep atonia control in chronic PTSD. More studies are needed to determine if neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients.
Article
Clinical Neurology
Carlos H. Schenck, Valerie Cochen de Cock, Simon J. G. Lewis, Naoko Tachibana, Clete Kushida, Raffaele Ferri
Summary: Updated guidelines for diagnosing RBD using vPSG procedures have been proposed, but a survey found that most health systems and medical communities in WSS member countries cannot implement the stricter guidelines, which would interfere with RBD diagnosis for many patients.
Review
Clinical Neurology
Frank Ralls, Lisa Cutchen, Madeleine M. Grigg-Damberger
Summary: The atonia of skeletal muscles during rapid eye movement sleep can cause behavior disorders, with elderly individuals having a higher risk of developing neurodegenerative diseases, while it is commonly found in individuals with narcolepsy and those taking antidepressant medications.
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Clinical Neurology
Ambra Stefani, Birgit Hoegl
Summary: Nightmare disorder and isolated sleep paralysis are common REM sleep disorders that can cause distress. Nightmare disorder is related to emotion regulation and hyperarousal, with imagery rehearsal therapy being an effective nonmedication treatment; isolated sleep paralysis may result from REM atonia persisting into wakefulness, and therapy mainly involves avoiding predisposing factors.
Article
Multidisciplinary Sciences
Madan Parajuli, Amy W. W. Amara, Mohamed Shaban
Summary: In this study, deep-learning based approaches were proposed to detect mild cognitive impairment in Parkinson's disease by analyzing sleep Electroencephalography signals. The proposed models achieved accurate prediction and identification of mild cognitive impairment, providing a promising computer-aided diagnostic tool for monitoring the progression of Parkinson's disease.
Article
Clinical Neurology
So Young Lee, Soo Jeong Kim, Hyo Jae Kim, Sang-Ahm Lee
Summary: Obstructive sleep apnea (OSA) can lead to misdiagnosis of rapid eye movement (REM) sleep behavior disorder (RBD) on video-polysomnography (video-PSG). This study found that OSA was associated with lower diagnostic accuracy of RBD on video-PSG. Patients who underwent continuous positive airway pressure (CPAP) studies were more likely to be diagnosed with RBD compared to their initial video-PSG diagnosis.
Article
Medicine, General & Internal
Sooyeoun You, Kyoung Sook Won, Keun Tae Kim, Hyang Woon Lee, Yong Won Cho
Summary: I-123-metaiodobenzylguanidine (MIBG) cardiac scintigraphy was used to assess cardiac autonomic dysfunction in patients with isolated rapid eye movement (REM) sleep behavior disorder, and the study found a correlation between reduced MIBG uptake and higher occurrence of REM sleep without atonia in these patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Javier Oltra, Anna Campabadal, Barbara Segura, Carme Uribe, Maria Jose Marti, Yaroslau Compta, Francesc Valldeoriola, Nuria Bargallo, Alex Iranzo, Carme Junque
Summary: Recent studies have linked rapid eye movement sleep behavior disorder (RBD) in Parkinson's disease (PD) with severe cognitive impairment and brain atrophy, yet whole-brain functional connectivity in these PD patients had not been explored. This study found disrupted functional connectivity in PD with probable RBD (PD-pRBD), specifically reduced connections involving cingulate areas with other brain regions, and abnormal network integrity in PD-pRBD, supporting its consideration as a severe PD subtype.
SCIENTIFIC REPORTS
(2021)