Article
Pharmacology & Pharmacy
Su Jeong Song, Joon Sig Choi
Summary: Self-assembled peptide nanostructures are gaining attention as drug delivery systems due to their enhanced biocompatibility and biodegradability compared to polymer-based carriers. In this study, an enzyme-responsive peptide nanoparticle system was introduced, which showed effective controlled release of cargo molecules. The system exhibited good cellular uptake and biocompatibility, and demonstrated superior anticancer effects compared to the control groups.
Review
Nanoscience & Nanotechnology
Hao Wang, Lingfeng Gao, Taojian Fan, Chen Zhang, Bin Zhang, Omar A. Al-Hartomy, Ahmed Al-Ghamdi, Swelm Wageh, Meng Qiu, Han Zhang
Summary: Nanomedicine strategies hold significant potential in smart drug delivery due to the unique composition of tumor tissue. Stimuli-responsive nanogels are increasingly important in cancer therapy, with the evolution from monoresponsive to multiresponsive systems. The properties, synthesis, and characterization of nanogels, as well as designing strategies for stimuli-response nanogels are discussed in this review, along with the potential applications of nanogel composites in constructing multistimulus-responsive nanoparticles for cancer diagnosis and therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Yanhong Liu, Linjiao Chen, Qingyang Shi, Qing Zhao, Hongshuang Ma
Summary: Tumor microenvironment-responsive polypeptide nanogels have excellent biocompatibility and degradability, and can be used for selective delivery of antitumor drugs. These nanogels can release drugs in response to stimuli from tumor tissues or cells, reducing side effects and improving efficacy.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Biomedical
Anais Brion, Juliane Chaud, Jeremie Leonard, Frederic Bolze, Stefan Chassaing, Benoit Frisch, Beatrice Heurtault, Antoine Kichler, Alexandre Specht
Summary: Photolytic reactions using photolabile protecting groups allow the optical control of liberating biological effectors. This study presents light-sensitive lipid nanocapsules that can release an antitumoral drug through photolysis. The use of original photon upconverting nanoparticles chemically conjugated to a coumarin-based photocleavable linker enables the release of the drug through upconversion luminescence-assisted photolysis using deep-red excitation. These findings have implications for future therapeutic applications in nanomedicine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Minhong Tan, Yang Xu, Ziqi Gao, Tiejun Yuan, Qingjun Liu, Rusen Yang, Bin Zhang, Lihua Peng
Summary: Precision medicine plays a crucial role in conducting real-time examination and administering on-demand medication. Existing therapeutic systems often implement these processes separately, leading to treatment interruption and limited recovery in patients. Intelligent wearable medical devices (IWMDs) have gained increasing attention for their non-invasive and customizable nature, and have significantly contributed to the research on biosensing and drug-delivery integrated systems. This review examines the latest progress in IWMDs research, including their mechanisms of integrating biosensing and on-demand drug delivery, and discusses the current challenges and future development directions.
ADVANCED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Fenghui Qiao, Zhiqi Jiang, Wen Fang, Jingzhi Sun, Qiaoling Hu
Summary: In this study, dual responsive nanoparticles were developed for drug delivery. The nanoparticles were able to release drug under the acidic tumor microenvironment and in the presence of mannitol. The nanoparticles were composed of chitosan, heparin, and poly(vinyl alcohol), and they exhibited dynamic covalent bonds and various functional groups for drug release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Takumi Sato, Yoshihiko Murakami
Summary: This study investigated the development of polysaccharide microparticles containing nanoparticles for temperature-responsive and two-step release of inclusions. These particles can release two differently charged compounds in a stepwise manner and efficiently deliver nanoparticles to the lungs.
Article
Pharmacology & Pharmacy
Xueqi Lin, Xingdi Wu, Xiang Chen, Ben Wang, Wen Xu
Summary: This review introduces stimuli-responsive drug delivery systems in eyes, summarizes their design and mechanisms, and briefly discusses their advantages and limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
Saeedreza Zeibi Shirejini, Josie Carberry, Karen Alt, Shaun D. Gregory, Christoph E. Hagemeyer
Summary: Cardiovascular disease is the primary cause of death worldwide. Blood-contacting medical devices increase the risk of thrombus formation, which can hinder blood flow and lead to severe consequences. This article explores the delicate balance between thrombosis and bleeding in medical devices, suggesting the use of shear-responsive nanomedicine-based drug delivery system for targeted administration to lower the bleeding risk. The lack of in vitro platforms for investigating the behavior of antithrombotic nanoparticles is a challenge hindering their clinical translation.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Lu Wang, Yunfeng Yan
Summary: RNA interference (RNAi) has potential in treating cancer and genetic disorders, but safe delivery methods remain a challenge. pH-responsive hybrid nanoparticles offer promise for siRNA delivery, with unique properties and potential benefits for therapeutic applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Nanoscience & Nanotechnology
Aihik Banerjee, Tanvi Jariwala, Youn-Kyung Baek, Dung Thi Hanh To, Youyi Tai, Junze Liu, Hyle Park, Nosang Myung, Jin Nam
Summary: The drawbacks of conventional drug administration are addressed by a magneto-, opto-stimuli responsive drug delivery system based on functionalized electrospun nanofibers with superparamagnetic iron oxide nanoparticles. This system allows on-demand drug delivery at specific times, overcoming the limitations of traditional drug delivery methods.
Article
Nanoscience & Nanotechnology
Qian Xie, Shi Gao, Rui Tian, Guohao Wang, Zainen Qin, Minglong Chen, Wenhui Zhang, Qiang Wen, Qingjie Ma, Lei Zhu
Summary: We developed a hyaluronic acid nanoparticle that carries a chemotherapy drug and a photosensitizer, and demonstrated its efficacy in tumor-bearing mice. This smart drug delivery system improves traditional chemotherapy and enhances photodynamic therapy. The nanoparticles release drugs in the tumor, providing effective treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Xiaoran Cai, Xiaolei Wang, Muye He, Yan Wang, Minbo Lan, Yuzheng Zhao, Feng Gao
Summary: The study successfully developed an oral nanoparticle delivery system for the effective treatment of inflammatory bowel disease by preparing FK506/HP-β-CD inclusion compounds and adsorbing ES100 and HA onto the nanoparticles loaded with FK506/HP-β-CD through electrostatic interactions. FK506@EHCh NPs displayed promising results in suppressing inflammation and showed potential for targeted treatment of inflammatory bowel disease.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Nanoscience & Nanotechnology
Linlan Yang, Kaijiong Zhang, Dongming Zheng, Yuxin Bai, Daifan Yue, Lichun Wu, Han Ling, Sujiao Ni, Haimin Zou, Bo Ye, Chang Liu, Yao Deng, Qiancheng Liu, Yan Li, Dongsheng Wang
Summary: Platelets play a crucial role in tumor progression and can be utilized in anti-tumor therapy. Targeting deficiencies in traditional platelet-based drugs have led to side effects, prompting researchers to design targeted drug delivery systems to improve the efficacy of anti-tumor treatment.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Ching-Hsiang Fan, Yi-Ju Ho, Chia-Wei Lin, Nan Wu, Pei-Hua Chiang, Chih-Kuang Yeh
Summary: In this article, the authors summarized recent progress on US-responsible drug carriers, focusing on the routes of enhancing delivery and applications. They discussed three specific mechanisms that enhance in vivo drug delivery via US with US-responsible carriers and reviewed the state-of-the-art materials for US-triggered drug delivery.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Multidisciplinary Sciences
I-Te Chen, Felipe Robles Poblete, Abhijeet Bagal, Yong Zhu, Chih-Hao Chang
Summary: In this study, the anelastic deformation behavior of periodic 3D nanolattices with extremely thin shell thicknesses was investigated using nanoindentation. The results showed that the nanolattices deform continuously with time under a constant load and exhibit recovery after unloading. Finite element analysis coupled with diffusion of point defects was conducted, which qualitatively agreed with the experimental results. The anelastic behavior was attributed to the diffusion of point defects in the presence of a stress gradient and was reversible when the deformation was removed. The FEA model quantified the evolution of the stress gradient and defect concentration and highlighted the importance of a wavy tube profile in the diffusion of point defects. The reported anelastic deformation behavior provides insights into the time-dependent response of nanolattice materials and has implications for energy dissipation applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Chemistry, Multidisciplinary
Giwon Lee, Mohammad Zarei, Qingshan Wei, Yong Zhu, Seung Goo Lee
Summary: Recent advances in nanolithography, miniaturization, and material science, along with developments in wearable electronics, have pushed sensor technology to fabricate highly sensitive, flexible, stretchable, and multimodal detection systems. Surface wrinkling, as an effective alternative, improves the sensing performance and mechanical deformability of flexible and stretchable sensors by releasing stress, preventing failure, and enlarging surface areas. This study discusses the recent developments in wrinkling structures for sensor applications, including the mechanics, geometry control, and fabricating methods. It reviews the current state and impact on various sensor types, such as strain, pressure, temperature, chemical, photodetectors, and multimodal sensors. The study also extrapolates the existing wrinkling approaches, designs, and sensing strategies into future applications.
Article
Chemistry, Multidisciplinary
Md Didarul Islam, Himendra Perera, Benjamin Black, Matthew Phillips, Muh-Jang Chen, Greyson Hodges, Allyce Jackman, Yuxuan Liu, Chang-Jin Kim, Mohammed Zikry, Saad Khan, Yong Zhu, Mark Pankow, Jong Eun Ryu
Summary: This study demonstrates a simple and scalable manufacturing technique to fabricate periodic microstructures by controlling ribbing defects in the coating process. The periodic microstructures exhibit hydrophobicity and can be utilized to improve boat speed as well as enhance mechanical and electrical properties.
ADVANCED MATERIALS INTERFACES
(2022)
Article
Robotics
Luis Vargas, He Huang, Yong Zhu, Derek Kamper, Xiaogang Hu
Summary: Tactile feedback in the hand is essential for interaction with objects. This study investigates how artificial tactile sensation affects the recognition of object properties using a myoelectrically controlled prosthetic hand. The results show that participants could discern object shape and size through the onset timing of tactile feedback.
IEEE ROBOTICS AND AUTOMATION LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Shuang Wu, Katherine Moody, Abhiroop Kollipara, Yong Zhu
Summary: We report a soft and stretchable resistive strain sensor with high sensitivity, large sensing range, and high robustness. The sensor is made of a silver nanowire network embedded below the surface of an elastomeric matrix. By applying periodic mechanical cuts to the top surface, the current flow in the sensor can be changed from uniform to along the conducting path defined by the open cracks. This stretchable strain sensor can be integrated into wearable systems for monitoring physiological functions and body motions associated with different levels of strain, such as blood pressure and lower back health.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Darpan Shukla, Yuxuan Liu, Yong Zhu
Summary: This study reports a silver nanowire ink with low conductive particle loading and an eco-friendly printing process suitable for printing on different substrates. The ink has simple formulation using biodegradable binder and non-toxic solvent, achieving a minimum feature size of 50 μm and a high conductivity of 6.70 x 10^6 S m^(-1). Flexible textile heater and wearable hydration sensor were fabricated to demonstrate the potential for wearable electronic applications.
Article
Chemistry, Multidisciplinary
Ankit Negi, Hwang Pill Kim, Zilong Hua, Anastasia Timofeeva, Xuanyi Zhang, Yong Zhu, Kara Peters, Divine Kumah, Xiaoning Jiang, Jun Liu
Summary: This paper demonstrates the room-temperature thermal modulation in 2.5 mm-thick Pb(Mg1/3Nb2/3)O-3-xPbTiO(3) (PMN-xPT) single crystals. Through the use of advanced poling conditions and a systematic study on composition and orientation dependence, a range of thermal conductivity switching ratios, with a maximum of approximately 1.27, is observed. The simultaneous measurements of piezoelectric coefficient (d(33)), domain wall density using polarized light microscopy (PLM), and birefringence change using quantitative PLM reveal an increase in domain wall density at intermediate poling states (0< d(33)< d(33(max)) compared to the unpoled state.
ADVANCED MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Li-Hua Shao, Xiaodong Qu, Tianyu Wang, Zheng Cui, Yuxuan Liu, Yong Zhu
Summary: Interfacial mechanics between elastoplastic fiber and elastic substrate/matrix are studied for various applications. Analytical models are derived for the fiber/substrate interface. The effect of plastic mechanical behavior of the fiber on interfacial stress transfer characteristics is studied for different cases. The research provides a guide for experiments with metal nanowires on a polymer substrate.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Chemistry, Multidisciplinary
Lijie He, Guangming Cheng, Yong Zhu, Harold S. Park
Summary: We use a hybrid diffusion- and nucleation-based kinetic Monte Carlo model to explain the significant influence of adatom diffusion on incipient surface dislocation nucleation in metal nanowires. We discover a stress-regulated diffusion mechanism that promotes the accumulation of diffusing adatoms near nucleation sites, explaining the experimental observations of temperature-dependent nucleation strength but weak strain-rate dependence. Additionally, our model shows that a decreasing rate of adatom diffusion with increasing strain rate leads to stress-controlled nucleation becoming the dominant mechanism at higher strain rates. Overall, our model provides new mechanistic insights into how surface adatom diffusion directly affects the nucleation process and mechanical properties of metal nanowires.
Article
Multidisciplinary Sciences
Giwon Lee, Oindrila Hossain, Sina Jamalzadegan, Yuxuan Liu, Hongyu Wang, Amanda C. Saville, Tatsiana Shymanovich, Rajesh Paul, Dorith Rotenberg, Anna E. Whitfield, Jean B. Ristaino, Yong Zhu, Qingshan Wei
Summary: Wearable plant sensors have great potential in smart agriculture. This paper introduces a multimodal wearable sensor attached to the lower leaf surface for continuous monitoring of plant physiology through tracking biochemical and biophysical signals. The sensor integrates VOCs, temperature, and humidity detection into one platform, with the attachment position chosen based on stomata density to enhance signal strength. The platform enables various stress monitoring applications and a machine learning model was developed for early detection of tomato spotted wilt virus using the sensor data.
Article
Multidisciplinary Sciences
Shuang Wu, Yaoye Hong, Yao Zhao, Jie Yin, Yong Zhu
Summary: In this study, a caterpillar-inspired crawling robot with multiple crawling modes is developed using a patterned soft heater consisting of silver nanowire networks in a liquid crystal elastomer (LCE)- based thermal bimorph actuator. The robot achieves bidirectional locomotion through the friction competition between the front and rear end with the ground, enabled by the patterned and distributed heaters and programmable heating. The behavior of the thermal bimorph is studied to optimize the local curvature of the robot under thermal stimuli. The robot's bidirectional actuation modes and crawling speeds are investigated, and its capability of passing through obstacles with limited spacing is demonstrated.
Article
Materials Science, Multidisciplinary
Ping Ren, Runqiao Song, Yong Zhu, Brendan O'Connor, Jingyan Dong
Summary: The demand for cost-effective fabrication of printed flexible transistors has increased due to the need for flexible interface devices like e-skins, wearables, and medical patches. This study develops electrohydrodynamic printing processes to fabricate all components of polymer-based organic thin film transistors, streamlining the fabrication procedure. The fully EHD-printed OTFTs show good electrical performance and great mechanical flexibility, providing a cost-effective route for flexible electronics.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Materials Science, Multidisciplinary
Runqiao Song, Ping Ren, Yuxuan Liu, Yong Zhu, Jingyan Dong, Brendan T. O'Connor
Summary: A solution-processed kirigami-inspired stretchable organic thin film transistor (OTFT) based pressure sensor array is introduced, which combines fine pattern control, mechanical stability, and pressure sensitivity. The porous gate dielectric achieved using a breath figure method enables tunable pressure sensitivity. The cut pattern in the substrate imparts stretchability while maintaining pressure sensor functionality.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Chemistry, Physical
Qiuyue Yang, Chen Li, Weixin Zhou, Yi Li, Yong Zhu, Yanwen Ma
Summary: A high-dielectric porous CaCu3Ti4O12 (CCTO)/reduced graphene oxide (rGO)/polydimethylsiloxane (PDMS) foam with a large dielectric constant and low Young's modulus is prepared. A wearable, breathable, and low crosstalk capacitive pressure sensor based on this foam is fabricated, displaying fast response speed, excellent sensitivity, and high gas permeability. The pressure sensor array integrated by multiple sensor units is also fabricated to detect spatial pressure distribution.
Review
Engineering, Biomedical
Yuxuan Liu, Darpan Shukla, Holly Newman, Yong Zhu
Summary: The COVID-19 pandemic has created significant stress on medical systems and global society, highlighting the need for real-time and remote monitoring of physiological parameters. This review focuses on the progress of soft wearable sensors in monitoring respiratory diseases and discusses future challenges and directions.
PROGRESS IN BIOMEDICAL ENGINEERING
(2022)
