Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions

African American genomes don’t capture Africa’s genetic diversity

(2023) Segun Fatumo et al.   NATURE

African genomes hold the key to accurate genetic risk prediction

(2023) Segun Fatumo et al.   Nature Human Behaviour

A roadmap to increase diversity in genomic studies

(2022) Segun Fatumo et al.   NATURE MEDICINE

The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review

(2022) Judit Kumuthini et al.   HUMAN GENETICS

Polygenic risk scores for CARDINAL study

(2022) Clement A. Adebamowo et al.   NATURE GENETICS

Leveraging fine-mapping and multipopulation training data to improve cross-population polygenic risk scores

(2022) Omer Weissbrod et al.   NATURE GENETICS

Promoting the genomic revolution in Africa through the Nigerian 100K Genome Project

(2022) Segun Fatumo et al.   NATURE GENETICS

Transferability of genetic risk scores in African populations

(2022) Abram B. Kamiza et al.   NATURE MEDICINE

Meta-analysis of sub-Saharan African studies provides insights into genetic architecture of lipid traits

(2022) Ananyo Choudhury et al.   Nature Communications

High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios

(2022) Marta Byrska-Bishop et al.   CELL

Community engagement in epigenomic and neurocognitive research on post-traumatic stress disorder in Rwandans exposed to the 1994 genocide against the Tutsi: lessons learned

(2022) Clarisse Musanabaganwa et al.   Epigenomics

African genetic diversity and adaptation inform a precision medicine agenda

(2021) Luisa Pereira et al.   NATURE REVIEWS GENETICS

Sequence three million genomes across Africa

(2021) Ambroise Wonkam   NATURE

Malaria is a cause of iron deficiency in African children

(2021) John Muthii Muriuki et al.   NATURE MEDICINE

Cross-cancer evaluation of polygenic risk scores for 16 cancer types in two large cohorts

(2021) Rebecca E. Graff et al.   Nature Communications

Non-communicable diseases pandemic and precision medicine: Is Africa ready?

(2021) Tinashe Chikowore et al.   EBioMedicine

Genetic risk scores for cardiometabolic traits in sub-Saharan African populations

(2021) Kenneth Ekoru et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Association of Novel Locus With Rheumatic Heart Disease in Black African Individuals

(2021) Tafadzwa Machipisa et al.   JAMA Cardiology

Responsible use of polygenic risk scores in the clinic: potential benefits, risks and gaps

(2021) et al.   NATURE MEDICINE

Systematic Review of Polygenic Risk Scores for Type 1 and Type 2 Diabetes

(2020) Felipe Padilla-Martínez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Predictive Accuracy of a Polygenic Risk Score–Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease

(2020) Joshua Elliott et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease

(2020) Jonathan D. Mosley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer?

(2020) Mark H. Kaplan et al.   Infectious Agents and Cancer

Minimal phenotyping yields genome-wide association signals of low specificity for major depression

(2020) Na Cai et al.   NATURE GENETICS

Polygenic risk scores: from research tools to clinical instruments

(2020) Cathryn M. Lewis et al.   Genome Medicine

The opportunity in African genome resource for precision medicine

(2020) Segun Fatumo   EBioMedicine

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populations

(2020) Ying Wang et al.   Nature Communications

Neuropsychiatric Genetics of African Populations-Psychosis (NeuroGAP-Psychosis): a case-control study protocol and GWAS in Ethiopia, Kenya, South Africa and Uganda

(2019) Anne Stevenson et al.   BMJ Open

Clinical use of current polygenic risk scores may exacerbate health disparities

(2019) Alicia R. Martin et al.   NATURE GENETICS

The Missing Diversity in Human Genetic Studies

(2019) Giorgio Sirugo et al.   CELL

Epidemiology, genetic epidemiology and Mendelian randomisation: more need than ever to attend to detail

(2019) Nuala A. Sheehan et al.   HUMAN GENETICS

Polygenic prediction via Bayesian regression and continuous shrinkage priors

(2019) Tian Ge et al.   Nature Communications

The “All of Us” Research Program

(2019)   NEW ENGLAND JOURNAL OF MEDICINE

Genome-wide Association Studies in Ancestrally Diverse Populations: Opportunities, Methods, Pitfalls, and Recommendations

(2019) Roseann E. Peterson et al.   CELL

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa

(2019) Deepti Gurdasani et al.   CELL

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

Stroke Among Young West Africans

(2018) Fred Stephen Sarfo et al.   STROKE

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes

(2018) Nasim Mavaddat et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The UK Biobank resource with deep phenotyping and genomic data

(2018) Clare Bycroft et al.   NATURE

Polygenic scores via penalized regression on summary statistics

(2017) Timothy Shin Heng Mak et al.   GENETIC EPIDEMIOLOGY

Cohort Profile: African Collaborative Center for Microbiome and Genomics Research’s (ACCME's) Human Papillomavirus (HPV) and Cervical Cancer Study

(2017) Sally N Adebamowo et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Introducing the TrypanoGEN biobank: A valuable resource for the elimination of human African trypanosomiasis

(2017) Hamidou Ilboudo et al.   PLoS Neglected Tropical Diseases

Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations

(2017) Sulev Reisberg et al.   PLoS One

Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network

(2016) Charlotte Osafo et al.   KIDNEY INTERNATIONAL

Genomics is failing on diversity

(2016) Alice B. Popejoy et al.   NATURE

Cohort Profile: FAMILY Cohort

(2015) Gabriel M Leung et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu

(2014) Liis Leitsalu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genome Wide Association Study of Fetal Hemoglobin in Sickle Cell Anemia in Tanzania

(2014) Siana Nkya Mtatiro et al.   PLoS One

Enabling the genomic revolution in Africa

(2014) et al.   SCIENCE

Rationale and cross-sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study

(2014) Charles Agyemang et al.   BMJ Open

Genetic Epidemiology of Type 2 Diabetes and Cardiovascular Diseases in Africa

(2013) Fasil Tekola-Ayele et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Seeking consent to genetic and genomic research in a rural Ghanaian setting: A qualitative study of the MalariaGEN experience

(2012) Paulina Tindana et al.   BMC Medical Ethics

Random-Effects Model Aimed at Discovering Associations in Meta-Analysis of Genome-wide Association Studies

(2011) Buhm Han et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Stroke incidence in rural and urban Tanzania: a prospective, community-based study

(2010) Richard Walker et al.   LANCET NEUROLOGY

African Genetic Diversity: Implications for Human Demographic History, Modern Human Origins, and Complex Disease Mapping

(2008) Michael C. Campbell et al.   Annual Review of Genomics and Human Genetics

Establishment of a biobank and pharmacogenetics database of African populations

(2008) Alice Matimba et al.   EUROPEAN JOURNAL OF HUMAN GENETICS