Unannotated microprotein EMBOW regulates the interactome and chromatin and mitotic functions of WDR5

WIN site inhibition disrupts a subset of WDR5 function

(2022) Andrew J. Siladi et al.   Scientific Reports

Nascent alt-protein chemoproteomics reveals a pre-60S assembly checkpoint inhibitor

(2022) Xiongwen Cao et al.   Nature Chemical Biology

Kastor and Polluks polypeptides encoded by a single gene locus cooperatively regulate VDAC and spermatogenesis

(2022) Shintaro Mise et al.   Nature Communications

Mapping subcellular localizations of unannotated microproteins and alternative proteins with MicroID

(2022) Zhenkun Na et al.   MOLECULAR CELL

Coordinating gene expression during the cell cycle

(2022) Martin Fischer et al.   TRENDS IN BIOCHEMICAL SCIENCES

An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism

(2021) Nunu Huang et al.   Cell Metabolism

Alt-RPL36 downregulates the PI3K-AKT-mTOR signaling pathway by interacting with TMEM24

(2021) Xiongwen Cao et al.   Nature Communications

Impact of WIN site inhibitor on the WDR5 interactome

(2021) Alissa D. Guarnaccia et al.   Cell Reports

WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways

(2021) Tianli Chen et al.   MOLECULAR THERAPY

Noncanonical open reading frames encode functional proteins essential for cancer cell survival

(2021) John R. Prensner et al.   NATURE BIOTECHNOLOGY

SCRIB Promotes Proliferation and Metastasis by Targeting Hippo/YAP Signalling in Colorectal Cancer

(2021) Hengyang Shen et al.   Frontiers in Cell and Developmental Biology

Targeting WD repeat domain 5 enhances chemosensitivity and inhibits proliferation and programmed death-ligand 1 expression in bladder cancer

(2021) Jingtong Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective

(2021) Xin Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Wnt signaling recruits KIF2A to the spindle to ensure chromosome congression and alignment during mitosis

(2021) Anja Bufe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a small protein-encoding cis-regulatory overlapping gene of the tumor suppressor gene Scribble in humans

(2021) Yuhta Nomura et al.   Communications Biology

Gene expression and cell identity controlled by anaphase-promoting complex

(2020) Eugene Oh et al.   NATURE

WDR5 is a conserved regulator of protein synthesis gene expression

(2020) Audra F Bryan et al.   NUCLEIC ACIDS RESEARCH

Pervasive functional translation of noncanonical human open reading frames

(2020) Jin Chen et al.   SCIENCE

Comparative proteomic profiling of unannotated microproteins and alternative proteins in human cell lines

(2020) Xiongwen Cao et al.   JOURNAL OF PROTEOME RESEARCH

Histone H4K20 Demethylation by Two hHR23 Proteins

(2020) Xiongwen Cao et al.   Cell Reports

Reconsidering proteomic diversity with functional investigation of small ORFs and alternative ORFs

(2020) Marie A. Brunet et al.   EXPERIMENTAL CELL RESEARCH

Non-AUG start codons: Expanding and regulating the small and alternative ORFeome

(2020) Xiongwen Cao et al.   EXPERIMENTAL CELL RESEARCH

WDR5 Promotes Proliferation and Correlates with Poor Prognosis in Oesophageal Squamous Cell Carcinoma

(2020) Di Huang et al.   OncoTargets and Therapy

The FUS gene is dual‐coding with both proteins contributing to FUS ‐mediated toxicity

(2020) Marie A Brunet et al.   EMBO REPORTS

Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

(2019) Teresa T. Bonello et al.   JOURNAL OF CELL BIOLOGY

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

(2019) Erin R. Aho et al.   Cell Reports

Alternative ORFs and small ORFs: shedding light on the dark proteome

(2019) Mona Wu Orr et al.   NUCLEIC ACIDS RESEARCH

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

(2018) Beth K. Neilsen et al.   BMC CANCER

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

(2018) Rebecca Stephens et al.   JOURNAL OF MOLECULAR BIOLOGY

WDR5 modulates cell motility and morphology and controls nuclear changes induced by a 3D environment

(2018) Pengbo Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

WDR5 Stabilizes Actin Architecture to Promote Multiciliated Cell Formation

(2018) Saurabh S. Kulkarni et al.   DEVELOPMENTAL CELL

The cell polarity protein Scrib functions as a tumor suppressor in liver cancer

(2017) Shweta Kapil et al.   Oncotarget

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

deepTools2: a next generation web server for deep-sequencing data analysis

(2016) Fidel Ramírez et al.   NUCLEIC ACIDS RESEARCH

WDR5 high expression and its effect on tumorigenesis in leukemia

(2016) Zheng Ge et al.   Oncotarget

Kif2a regulates spindle organization and cell cycle progression in meiotic oocytes

(2016) Zi-Yun Yi et al.   Scientific Reports

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

Discovery and characterization of smORF-encoded bioactive polypeptides

(2015) Alan Saghatelian et al.   Nature Chemical Biology

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

(2015) Florian Grebien et al.   Nature Chemical Biology

Accurate Proteome-wide Label-free Quantification by Delayed Normalization and Maximal Peptide Ratio Extraction, Termed MaxLFQ

(2014) Jürgen Cox et al.   MOLECULAR & CELLULAR PROTEOMICS

H3K4me3 Interactions with TAF3 Regulate Preinitiation Complex Assembly and Selective Gene Activation

(2013) Shannon M. Lauberth et al.   CELL

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

(2013) Dattatreya Mellacheruvu et al.   NATURE METHODS

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5

(2012) Guillermo Senisterra et al.   BIOCHEMICAL JOURNAL

Peptidomic discovery of short open reading frame–encoded peptides in human cells

(2012) Sarah A Slavoff et al.   Nature Chemical Biology

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

The Roles of Cyclin A2, B1, and B2 in Early and Late Mitotic Events

(2010) Delquin Gong et al.   MOLECULAR BIOLOGY OF THE CELL

Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans

(2009) S. E. Calvo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Errata.PCSK9 function and physiology: Fig. 1.

(2008) Andrew S. Peterson et al.   JOURNAL OF LIPID RESEARCH

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY