Potential of phage depolymerase for the treatment of bacterial biofilms

Loss of a Branch Sugar in the Acinetobacter baumannii K3-Type Capsular Polysaccharide Due To Frameshifts in the gtr6 Glycosyltransferase Gene Leads To Susceptibility To Phage APK37.1

(2023) Olga Y. Timoshina et al.   Microbiology Spectrum

Bacterial biofilm infections, their resistance to antibiotics therapy and current treatment strategies

(2022) Anirudh Singh et al.   Biomedical Materials

Environmental, Microbiological, and Immunological Features of Bacterial Biofilms Associated with Implanted Medical Devices

(2022) Marina Caldara et al.   CLINICAL MICROBIOLOGY REVIEWS

Capsule-Targeting Depolymerases Derived from Acinetobacter baumannii Prophage Regions

(2022) Alena Y. Drobiazko et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phage-Derived Depolymerase as an Antibiotic Adjuvant Against Multidrug-Resistant Acinetobacter baumannii

(2022) Xi Chen et al.   Frontiers in Microbiology

The Specific Capsule Depolymerase of Phage PMK34 Sensitizes Acinetobacter baumannii to Serum Killing

(2022) Karim Abdelkader et al.   Antibiotics-Basel

Immobilized enzymes as potent antibiofilm agent

(2022) Dibyajit Lahiri et al.   BIOTECHNOLOGY PROGRESS

Sulopenem or Ciprofloxacin for the Treatment of Uncomplicated Urinary Tract Infections in Women: A Phase 3, Randomized Trial

(2022) Michael W Dunne et al.   CLINICAL INFECTIOUS DISEASES

Evolution of Virulence, Fitness, and Carbapenem Resistance Transmission in ST23 Hypervirulent Klebsiella pneumoniae with the Capsular Polysaccharide Synthesis Gene wcaJ Inserted via Insertion Sequence Elements

(2022) Shuyi Wang et al.   Microbiology Spectrum

Phage Cocktail Powder for Pseudomonas aeruginosa Respiratory Infections

(2021) Mengyu Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bacteriophage-Derived Depolymerases against Bacterial Biofilm

(2021) Gracja Topka-Bielecka et al.   Antibiotics-Basel

Phage φAB6-Borne Depolymerase Combats Acinetobacter baumannii Biofilm Formation and Infection

(2021) Md. Shahed-Al-Mahmud et al.   Antibiotics-Basel

Toward a Phage Cocktail for Tuberculosis: Susceptibility and Tuberculocidal Action of Mycobacteriophages against Diverse Mycobacterium tuberculosis Strains

(2021) Carlos A. Guerrero-Bustamante et al.   mBio

Staphylococcus epidermidis Phages Transduce Antimicrobial Resistance Plasmids and Mobilize Chromosomal Islands

(2021) Lenka Fišarová et al.   mSphere

Phage Digestion of a Bacterial Capsule Imparts Resistance to Two Antibiotic Agents

(2021) Cheng-Hung Luo et al.   Microorganisms

Isolation and Characterization of a Novel Lytic Bacteriophage against the K2 Capsule-Expressing Hypervirulent Klebsiella pneumoniae Strain 52145, and Identification of Its Functional Depolymerase

(2021) Botond Zsombor Pertics et al.   Microorganisms

Isolation and characterization of lytic phage TUN1 specific for Klebsiella pneumoniae K64 clinical isolates from Tunisia

(2021) Simone Eckstein et al.   BMC MICROBIOLOGY

Multidrug-resistant Acinetobacter baumannii infections in COVID-19 patients hospitalized in intensive care unit

(2021) Alessandro Russo et al.   INFECTION

Spatially resolved analysis of Pseudomonas aeruginosa biofilm proteomes measured by laser ablation sample transfer

(2021) Aruni Chathurya Pulukkody et al.   PLoS One

Novel Klebsiella pneumoniae K23-Specific Bacteriophages From Different Families: Similarity of Depolymerases and Their Therapeutic Potential

(2021) Roman B. Gorodnichev et al.   Frontiers in Microbiology

The K26 capsular polysaccharide from Acinetobacter baumannii KZ-1098: Structure and cleavage by a specific phage depolymerase

(2021) Anastasiya A. Kasimova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The Mutation in wbaP cps Gene Cluster Selected by Phage-Borne Depolymerase Abolishes Capsule Production and Diminishes the Virulence of Klebsiella pneumoniae

(2021) Marta Kaszowska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Quinolone-resistant uropathogenic E. coli: is there a relation between qnr genes, gyrA gene target site mutation and biofilm formation?

(2021) Amira M. Sultan et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Novel Phage-Derived Depolymerase with Activity against Proteus mirabilis Biofilms

(2021) Cormac J. Rice et al.   Microorganisms

A Novel Tail-Associated O91-Specific Polysaccharide Depolymerase from Podophage Reveals Lytic Efficacy of Shiga Toxin-Producing E. coli

(2020) Yibao Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolation of Four Lytic Phages Infecting Klebsiella pneumoniae K22 Clinical Isolates from Spain

(2020) Pilar Domingo-Calap et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Two Depolymerases From Phage IME205 and Their Antivirulent Functions on K47 Capsule of Klebsiella pneumoniae

(2020) Yannan Liu et al.   Frontiers in Microbiology

Tailspike with EPS-depolymerase activity, encoded by a phage belonging to a new genus, makes Providencia stuartii susceptible to serum-mediated killing

(2020) Hugo Oliveira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural and Functional Studies of a Klebsiella Phage Capsule Depolymerase Tailspike: Mechanistic Insights into Capsular Degradation

(2020) Flavia Squeglia et al.   STRUCTURE

Characterization of different alginate lyases for dissolving Pseudomonas aeruginosa biofilms

(2020) Núria Blanco-Cabra et al.   Scientific Reports

Identification of a Novel Acinetobacter baumannii Phage-Derived Depolymerase and Its Therapeutic Application in Mice

(2020) Can Wang et al.   Frontiers in Microbiology

Advantages and limitations of microtiter biofilm assays in the model of antibiofilm activity of Klebsiella phage KP34 and its depolymerase

(2020) Agnieszka Latka et al.   Scientific Reports

Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance

(2020) Cristina Uruén et al.   Antibiotics-Basel

Isolation and characterization of human pathogenic multidrug resistant bacteria associated with plastic litter collected in Zanzibar

(2020) Farah N. Rasool et al.   JOURNAL OF HAZARDOUS MATERIALS

Relationship between antibiotic resistance, efflux pumps, and biofilm formation in extended-spectrum β-lactamase producing Klebsiella pneumoniae

(2019) İbrahim Türkel et al.   JOURNAL OF CHEMOTHERAPY

Identification and characterization of capsule depolymerase Dpo48 from Acinetobacter baumannii phage IME200

(2019) Yannan Liu et al.   PeerJ

Identification of three podoviruses infecting Klebsiella encoding capsule depolymerases that digest specific capsular types

(2019) Yi-Jiun Pan et al.   Microbial Biotechnology

Identification of a lytic Pseudomonas aeruginosa phage depolymerase and its anti-biofilm effect and bactericidal contribution to serum

(2019) Liyuan Mi et al.   VIRUS GENES

Phage-encoded K2 capsule depolymerase is highly stable, refractory to resistance and protects larvae and mice from Acinetobacter baumannii sepsis

(2019) Hugo Oliveira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Novel Polysaccharide Depolymerase Encoded by the Phage SH-KP152226 Confers Specific Activity Against Multidrug-Resistant Klebsiella pneumoniae via Biofilm Degradation

(2019) Yunqiang Wu et al.   Frontiers in Microbiology

Bacterial biofilm and associated infections

(2018) Muhsin Jamal et al.   Journal of the Chinese Medical Association

Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity

(2018) A. C. Hernandez-Morales et al.   JOURNAL OF VIROLOGY

A Mechanism of Unidirectional Transformation, Leading to Antibiotic Resistance, Occurs within Nasopharyngeal Pneumococcal Biofilm Consortia

(2018) Santiago M. Lattar et al.   mBio

Hypoxia arising from concerted oxygen consumption by neutrophils and microorganisms in biofilms

(2018) Yilin Wu et al.   Pathogens and Disease

Acinetobacter nosocomialis: Defining the Role of Efflux Pumps in Resistance to Antimicrobial Therapy, Surface Motility, and Biofilm Formation

(2018) Daniel B. Knight et al.   Frontiers in Microbiology

Therapeutic Application of Bacteriophage PHB02 and Its Putative Depolymerase Against Pasteurella multocida Capsular Type A in Mice

(2018) Yibao Chen et al.   Frontiers in Microbiology

Functional analysis and anti-virulent properties of a new depolymerase from a myovirus that infects Acinetobacter baumannii capsule K45

(2018) Hugo Oliveira et al.   JOURNAL OF VIROLOGY

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms

(2018) Grazyna Majkowska-Skrobek et al.   Frontiers in Microbiology

Klebsiella Phage ΦK64-1 Encodes Multiple Depolymerases for Multiple Host Capsular Types

(2017) Yi-Jiun Pan et al.   JOURNAL OF VIROLOGY

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

(2017) Han Lin et al.   Frontiers in Microbiology

Biofilm disruption by an air bubble reveals heterogeneous age-dependent detachment patterns dictated by initial extracellular matrix distribution

(2017) Hongchul Jang et al.   npj Biofilms and Microbiomes

Two T7-like Bacteriophages, K5-2 and K5-4, Each Encodes Two Capsule Depolymerases: Isolation and Functional Characterization

(2017) Pei-Fang Hsieh et al.   Scientific Reports

The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence

(2017) Tomasz Olszak et al.   Scientific Reports

Gel-Entrapped Staphylococcus aureus Bacteria as Models of Biofilm Infection Exhibit Growth in Dense Aggregates, Oxygen Limitation, Antibiotic Tolerance, and Heterogeneous Gene Expression

(2016) Breana Pabst et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage-encoded depolymerases: their diversity and biotechnological applications

(2016) Diana P. Pires et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

United Nations meeting on antimicrobial resistance

(2016)   BULLETIN OF THE WORLD HEALTH ORGANIZATION

Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy

(2016) Grażyna Majkowska-Skrobek et al.   Viruses-Basel

Genetic Dissection of the Regulatory Network Associated with High c-di-GMP Levels in Pseudomonas putida KT2440

(2016) María Isabel Ramos-González et al.   Frontiers in Microbiology

Penetration barrier contributes to bacterial biofilm-associated resistance against only select antibiotics, and exhibits genus-, strain- and antibiotic-specific differences

(2016) Rachna Singh et al.   Pathogens and Disease

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

Bacteriophages and Phage-Derived Proteins – Application Approaches

(2015) Zuzanna Drulis-Kawa et al.   CURRENT MEDICINAL CHEMISTRY

The Caulobacter crescentus Transducing Phage Cr30 is a Unique Member of the T4-Like Family of Myophages

(2015) Bert Ely et al.   CURRENT MICROBIOLOGY

Biofilm-specific antibiotic tolerance and resistance

(2015) I. Olsen   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Do orally administered antibiotics reach concentrations in the middle ear sufficient to eradicate planktonic and biofilm bacteria? A review

(2015) Katherine Belfield et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Gene Transfer Efficiency in Gonococcal Biofilms: Role of Biofilm Age, Architecture, and Pilin Antigenic Variation

(2015) Nadzeya Kouzel et al.   JOURNAL OF BACTERIOLOGY

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

Glycoside hydrolase family 32 is present in Bacillus subtilis phages

(2015) Halim Maaroufi et al.   Virology Journal

Staphylococcus epidermidis: metabolic adaptation and biofilm formation in response to different oxygen concentrations

(2015) Cristina Uribe-Alvarez et al.   Pathogens and Disease

A direct screen for c-di-GMP modulators reveals aSalmonellaTyphimurium periplasmic ʟ-arginine–sensing pathway

(2015) Erez Mills et al.   Science Signaling

Staphylococcus aureus Biofilms Promote Horizontal Transfer of Antibiotic Resistance

(2013) Victoria J. Savage et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation of a Bacteriophage Specific for a New Capsular Type of Klebsiella pneumoniae and Characterization of Its Polysaccharide Depolymerase

(2013) Chun-Ru Hsu et al.   PLoS One

Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era

(2013) M. Kostakioti et al.   Cold Spring Harbor Perspectives in Medicine

Sticky Situations: Key Components That Control Bacterial Surface Attachment

(2012) O. E. Petrova et al.   JOURNAL OF BACTERIOLOGY

Complete genomic sequence of the Lactobacillus temperate phage LF1

(2011) Bo Hyun Yoon et al.   ARCHIVES OF VIROLOGY

The T7-Related Pseudomonas putida Phage φ15 Displays Virion-Associated Biofilm Degradation Properties

(2011) Anneleen Cornelissen et al.   PLoS One

Structural changes induced by a lytic bacteriophage make ciprofloxacin effective against older biofilm of Klebsiella pneumoniae

(2010) Vivek Verma et al.   BIOFOULING

Antibiotic resistance of bacterial biofilms

(2010) Niels Høiby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Penetration of antibiotics through Staphylococcus aureus and Staphylococcus epidermidis biofilms

(2010) R. Singh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Bacteriophage-derived enzyme that depolymerizes the alginic acid capsule associated with cystic fibrosis isolates ofPseudomonas aeruginosa

(2009) T. Glonti et al.   JOURNAL OF APPLIED MICROBIOLOGY

Increased mutability of Pseudomonas aeruginosa in biofilms

(2008) K. Driffield et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY