Article
Chemistry, Analytical
Haidong Feng, Alexander R. Jafek, Bonan Wang, Hayden Brady, Jules J. Magda, Bruce K. Gale
Summary: This paper studies particle focusing in viscoelastic flow and predicts the focusing position by analyzing the force balance. The research finds that particle separation resolution can be improved in viscoelastic flows.
Article
Chemistry, Analytical
Mohammad Moein Naderi, Ludovica Barilla, Jian Zhou, Ian Papautsky, Zhangli Peng
Summary: The study on elasto-inertial focusing highlighted the interaction between elastic force and shear-gradient lift force leading to different particle focusing patterns. Both experimental and simulation studies were conducted to investigate the effects of flowrate, particle size, and shear-thinning extent on focusing patterns, emphasizing the importance of accurately estimating shear-thinning extent in modeling.
Article
Chemistry, Analytical
Dan Yuan, Sheng Yan, Jun Zhang, Rosanne M. Guijt, Qianbin Zhao, Weihua Li
Summary: This study introduces a novel method to separate shape-synchronized cyanobacterial cell populations using viscoelastic microfluidics, which opens up a new field of application in microfluidics technology.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Analytical
Jun-Jie Bai, Xuan Zhang, Xing Wei, Yu Wang, Cheng Du, Ze-Jun Wang, Ming-Li Chen, Jian-Hua Wang
Summary: Exosomes are crucial biomarkers for intercellular communication and disease diagnosis and treatment. This study presents a microfluidic chip called DEIC for isolating high-purity exosomes from small-volume biological samples. The chip utilizes elastoinertial separation to remove protein contaminants and achieves a 70.6% recovery and a 91.4% removal rate for proteins. The technique enables individual-vesicle-level biomarker analysis and shows potential for integration with downstream exosome analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Mechanics
Mohammad Charjouei Moghadam, Armin Eilaghi, Pouya Rezai
Summary: This study used numerical simulation to investigate elasto-inertial focusing of microparticles in a straight microchannel, proposing a new threshold for particle dispersion prediction. An empirical non-dimensional correlation was developed to predict elasto-inertial particle dispersion in straight square cross-sectional microchannels, reducing the predicted dispersion variation from about 15% to less than about 5%.
Article
Chemistry, Analytical
Lei Zhao, Mengqi Gao, Yanbing Niu, Jianchun Wang, Shaofei Shen
Summary: A novel microchannel structure was developed for flow-rate and particle-size insensitive inertial focusing; efficient focusing of particles and tumor cells at different flow rates was achieved through enhanced secondary flow; providing important reference for the development of portable inertial microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Chemical
Afshin Shiriny, Morteza Bayareh
Summary: A novel microscale device for continuous flow separation of two types of circulating tumor cells from blood cells was proposed in this study. The separation efficiency reached 100% over a range of Reynolds numbers from 90 to 110, achieved through inertial forces.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Biochemical Research Methods
Andrew S. Clark, Adriana San-Miguel
Summary: We have developed two microfluidic lobe filters inspired by the filtration mechanism of manta rays to address clogging issues. These filters can efficiently filtrate particles around 10-30 μm with high throughput and precise control, showing increased filtration efficiency with fluid flow rate.
Article
Engineering, Chemical
Haotian Cha, Hoseyn A. Amiri, Sima Moshafi, Ali Karimi, Ali Nikkhah, Xiangxun Chen, Hang T. Ta, Nam-Trung Nguyen, Jun Zhang
Summary: Inertial microfluidics is a technique that uses the finite inertia of fluid at high flow speed to manipulate and separate microparticles. Embedding periodic micro-obstacles into curvilinear channels has been found to be an effective strategy to improve inertial focusing and separation. This study systematically investigated the influence of micro-obstacles on inertial focusing and developed a high-resolution microfluidic device for particle and cell separation. The results showed that concave obstacles were more effective in tuning particle inertial focusing and separation compared to convex obstacles, and the square concave obstacle channel offered the highest separation resolution. The developed microfluidic device showed high-efficiency separation of polystyrene beads and U87MG cancer cells from blood.
CHEMICAL ENGINEERING SCIENCE
(2023)
Article
Mechanics
I. Banerjee, M. E. Rosti, T. Kumar, L. Brandt, A. Russom
Summary: A unique tunable trend in particle focusing is reported in elasto-inertial flows, where particles can be tuned to different focusing bandwidths. Numerical simulations and experimental observations show that particle focusing is affected by minute amounts of elasticity and flow rates. The study provides a new understanding of particle focusing in weakly elastic and strongly inertial flows, with potential applications in microfluidics-based biological sorting.
Article
Chemistry, Analytical
Uihwan Kim, Byeolnim Oh, Jiyeon Ahn, Sangwook Lee, Younghak Cho
Summary: In this study, an integrated microfluidic device was proposed for non-contact, label-free separation of particles and cells using a combination of inertial microfluidics and acoustophoresis. The device demonstrated excellent separation performance and high recovery ratio, making it a potential alternative to current cell separation methods.
Article
Biochemical Research Methods
Dan Yuan, Sharda Yadav, Hang T. Ta, Hedieh Fallahi, Hongjie An, Navid Kashaninejad, Chin Hong Ooi, Nam-Trung Nguyen, Jun Zhang
Summary: This study investigated sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel, demonstrating its application on various types of particles and cells. The zigzag structure of the channel allows for reduced device footprint and channel length without sacrificing focusing performance.
Article
Chemistry, Multidisciplinary
Afshin Shiriny, Morteza Bayareh, Afshin Ahmadi Nadooshan
Summary: A novel microfluidic device is designed to focus microparticles based on inertial and magnetophoretic impacts, achieving 100% separation efficiency of polystyrene particles with three different sizes. High purity particle collection can be achieved using Halbach array of magnets, with optimal situations determined by investigating inlet flow velocity, magnets' configuration, and their distance from the microchannel.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Biochemical Research Methods
Arash Dalili, Mina Hoorfar
Summary: This study compares sheath-assisted and sheathless DEP separation of three sizes of microparticles using tilted electrodes. The results show that the sheath-assisted design has higher separation efficiency, while the sheathless design offers higher sample throughput.
Article
Mechanics
Takayuki Suzuki, Srivathsan Kalyan, Cynthia Berlinicke, Samantha Yoseph, Donald J. Zack, Soojung Claire Hur
Summary: Viscoelastic focusing is a promising method for manipulating micro and nanoscale bioparticles. This study investigates the mechanisms and applications of viscoelastic focusing in rectangular microchannels. By varying the fluid elasticity and inertia, the flow characteristics driving cell focusing are revealed. The findings provide guidance for the application of viscoelastic focusing in flow cytometry and particle sorting, as well as valuable insights for device design.
Article
Chemistry, Physical
Vladimir Paunovic, Sharon Mitchell, Rene Verel, Sung Sik Lee, Javier Perez-Ramirez
JOURNAL OF PHYSICAL CHEMISTRY C
(2020)
Article
Biochemical Research Methods
Jae Bem You, Byungjin Lee, Yunho Choi, Chang-Soo Lee, Matthias Peter, Sung Gap Im, Sung Sik Lee
Editorial Material
Chemistry, Analytical
Sung Sik Lee
Article
Cell Biology
Frank Van Drogen, Nicolas Dard, Serge Pelet, Sung Sik Lee, Ranjan Mishra, Nevena Srejic, Matthias Peter
Article
Multidisciplinary Sciences
Mart-Erik Maeots, Byungjin Lee, Andrea Nans, Seung-Geun Jeong, Mohammad M. N. Esfahani, Shan Ding, Daniel J. Smith, Chang-Soo Lee, Sung Sik Lee, Matthias Peter, Radoslav Enchev
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
Bookun Kim, Sung Sik Lee, Tae Hyeon Yoo, Ju Min Kim
Summary: This study found that under pressure-driven microflows, particles in human saliva and blood plasma are influenced by their viscoelastic properties, forming a focused stream. The degree of particle focusing varies among samples, indicating that the viscoelasticity of biofluids may be affected by their compositions.
Article
Environmental Sciences
Marlene Schwarzfischer, Anna Niechcial, Sung Sik Lee, Brian Sinnet, Marcin Wawrzyniak, Andrea Laimbacher, Kirstin Atrott, Roberto Manzini, Yasser Morsy, Janine Haefliger, Silvia Lang, Gerhard Rogler, Ralf Kaegi, Michael Scharl, Marianne R. Spalinger
Summary: Plastic pollution is a significant global challenge that poses a threat to the environment and human health. Ingested plastic particles, such as nanoplastic and microplastic, were found to have no promoting effects on inflammatory bowel disease (IBD), but potential accumulative effects on gastrointestinal health cannot be ruled out.
Article
Chemistry, Multidisciplinary
Julian T. C. Wennmacher, Soheil Mahmoudi, Przemyslaw Rzepka, Sung Sik Lee, Tim Gruene, Vladimir Paunovic, Jeroen A. van Bokhoven
Summary: This study presents the direct mapping of coke in the micropores of ZSM-5 catalysts using single-crystal electron diffraction analysis. The findings reveal that coke formation is associated with catalyst deactivation and provide a new method for analyzing coke deposition in the micropore domain.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Vladimir Paunovic, Vitaly Sushkevich, Przemyslaw Rzepka, Luca Artiglia, Roland Hauert, Sung Sik Lee, Jeroen A. van Bokhoven
Summary: This study investigates the potential of regenerating catalysts by reacting coke deposits with hydrogen. The reactivation efficiency is enhanced under high pressure, and hydrogen treatment can remove coke and restore catalyst activity in various Si/Al ratios.
JOURNAL OF CATALYSIS
(2022)
Article
Multidisciplinary Sciences
Vera M. Kissling, Giordano Reginato, Eliana Bianco, Kristina Kasaciunaite, Janny Tilma, Gea Cereghetti, Natalie Schindler, Sung Sik Lee, Raphael Guerois, Brian Luke, Ralf Seidel, Petr Cejka, Matthias Peter
Summary: This study reveals the oligomerization mechanism of the Mre11-Rad50 complex and its functional significance in DNA damage repair. The results show that Rad50 mediates the oligomerization of the Mre11-Rad50 complex, and its mutations may be linked to hereditary cancer predisposition.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Anne C. Meinema, Anna Marzelliusardottir, Mihailo Mirkovic, Theo Aspert, Sung Sik Lee, Gilles Charvin, Yves Barral
Summary: The attachment of DNA circles to NPCs causes NPCs to lose their nuclear and cytoplasmic complexes in replicatively ageing yeast cells. This process is related to the replicative lifespan of the cells.
Article
Chemistry, Multidisciplinary
Yang Jun Kang, Sami Serhrouchni, Asya Makhro, Anna Bogdanova, Sung Sik Lee
Summary: Assessing the deformability of red blood cells (RBCs) as a biomarker usually requires expensive equipment. This study presents a simple method for quantifying RBC deformability using a microfluidic device. The temporal variation in blood pressure allowed the definition of a clogging index (CI) as a new marker of RBC deformability. Experimental results showed that the CI method provides reliable information on RBC deformability, comparable to traditional methods such as ektacytometry.
Article
Multidisciplinary Sciences
Maximilian Mosbacher, Sung Sik Lee, Gilad Yaakov, Mariona Nadal-Ribelles, Eulalia de Nadal, Frank van Drogen, Francesc Posas, Matthias Peter, Manfred Claassen
Summary: This study characterizes the regulation of MAP kinase Hog1 in Saccharomyces cerevisiae and reveals a mixed phosphorylation mechanism regulated by a positive feedback loop. Simulations show that this mechanism is necessary for full sensitivity to stimuli and robustness to perturbations.
NATURE COMMUNICATIONS
(2023)
Article
Biochemical Research Methods
Sun Ok Hong, Ki-Su Park, Dong-Yeong Kim, Sung Sik Lee, Chang-Soo Lee, Ju Min Kim
Summary: The study discusses the challenge of mixing in microscale flows and proposes an efficient mixing scheme by combining inertio-elastic flow instability with a modified serpentine channel design. Results show that this new scheme achieves highly efficient mixing over a wider range of flow rates and is successfully applied to the continuous synthesis of silica nanoparticles, resulting in nanoparticles with more uniform size distribution.
Article
Biochemical Research Methods
Byungjin Lee, Seong-Geun Jeong, Si Hyung Jin, Ranjan Mishra, Matthias Peter, Chang-Soo Lee, Sung Sik Lee
Article
Engineering, Chemical
Qing Han, Mengqing Shi, Linkai Han, Di Liu, Mingwei Tong, Yuxin Xie, Zhonghua Xiang
Summary: Developing highly efficient bifunctional oxygen electrocatalysts is crucial for zinc-air flow batteries. Metal-organic frameworks (MOFs) and covalent organic polymers (COPs) have emerged as promising alternatives due to their designable and controllable atomic-level structures. However, their catalytic performances are limited by conductivity and catalytic activity. In this study, nanosheet FeNi-MOF and iron phthalocyanine rich COP hybrid materials are assembled through the pi-pi stacking effect to create highly efficient bifunctional electrocatalysts. The resulting catalyst exhibits superior catalytic performance and stability, making it a promising candidate for zinc-air flow batteries.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Daria Grigorash, Dmytro Mihrin, Rene Wugt Larsen, Erling H. Stenby, Wei Yan
Summary: The article introduces a new approach to describe the cross-association between molecules, allowing for the simulation of weakly bound molecular complexes with different conformations in mixtures. By incorporating this approach into the equation of state, accurate predictions of vapor-liquid equilibrium and liquid-liquid equilibrium can be made. The new method is validated through experiments on alcohol and acid mixtures, with the results compared to experimental data, demonstrating its accuracy and reliability.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Mohammed Al-Sharabi, Daniel Markl, Vincenzino Vivacqua, Prince Bawuah, Natalie Maclean, Andrew P. E. York, Axel Zeitler
Summary: This study used terahertz pulsed imaging to investigate the transport process of different solvents into ceramic catalytic materials. The results showed that the heating rate of the samples influenced the water transport rate, while the viscosity of 1-octanol slowed down its transport.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chukwunonso Anyaoku, Sati Bhattacharya, Rajarathinam Parthasarathy
Summary: This study aimed to enhance understanding of settling dynamics in viscoelastic fluids by developing a semi-empirical correlation and a dimensionless ratio, which accurately described the characteristics of settling suspensions.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Antti I. Koponen, Janika Viitala, Atsushi Tanaka, Baranivignesh Prakash, Olli-Ville Laukkanen, Ari Jasberg
Summary: This study focuses on the development of foam application chemicals for the paper and board industry. The research explores the rheology of the polyvinyl alcohol foam used in the process. Measurements were conducted to determine the foam viscosity and slip flow. The results suggest that slip flow contributes significantly to the total flow rate, and the obtained viscosity and slip models provide a solid foundation for industrial processes.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Dalei Sun, Jinghui Cai, Yating Yang, Zhiwu Liang
Summary: In this study, Fe-doped alpha-Bi2O3 catalysts with different Fe/Bi molar ratios were synthesized and utilized in the carbonylation of isobutyl amine with CO2. The results showed that Fe doping significantly enhanced the catalytic abilities of alpha-Bi2O3.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Yuan Tian, Xinxin Wang, Yanrong Liu, Wenping Hu
Summary: This paper predicts the solubility of nitrogen gas in ionic liquids (ILs) using two quantitative structure-property relationship (QSPR) models. By combining machine learning methods and ionic fragments contribution method, the accuracy and reliability of the prediction models are improved.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Liwang Wang, Wei Liu, Pan Yang, Yulong Chang, Xiaoxu Duan, Lingyu Xiao, Yaoming Hu, Jiwei Wu, Liang Ma, Hualin Wang
Summary: This study investigates the effective phase interfacial area (ae) of hydro-jet cyclones at different injection angles. The results show that a 45 degrees upward incidence angle yields the most favorable flow field characteristics for efficient mass transfer. The significant enhancement in ae of the hydro-jet cyclones offers the advantage of reducing equipment volume and cost savings.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Chuanjun Wu, Jiangzhi Chen, Jiyue Sun, I-Ming Chou, Shenghua Mei, Juezhi Lin, Lei Jiang
Summary: In this study, the solubility of H2S hydrate in water was measured using Raman spectroscopy. The results showed that the solubility increases with temperature under certain equilibrium conditions, and the solubility also depends on pressure and temperature under different equilibrium conditions. A thermodynamic model based on the van der Waals-Platteeuw theory was developed to predict the solubility, demonstrating its accuracy.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Lorenzo Brivio, Serena Meini, Mattia Sponchioni, Davide Moscatelli
Summary: This study investigates the influence of three main parameters and proposes a kinetic model to predict the optimal operating conditions for high yield of dimethyl terephthalate (DMT) in the chemical recycling process of polyethylene terephthalate (PET).
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Hongju Lin, Fanhui Liao, Yanchang Chu, Mingyu Xie, Lun Pan, Yuanyuan Wang, Lijian Leng, Donghai Xu, Le Yang, Gangfeng Ouyang
Summary: A honeycomb NiCo/C-Na catalyst with a micro-meso-macroporous structure has been fabricated and shown to have significantly higher catalytic activity for the decarboxylation of fatty acids. It also proves to be efficient in upgrading sludge HTL bio-crude, resulting in a biofuel with decreased viscosity and increased density.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Xiaoxian Li, Rui Li, Min Lin, Mingde Yang, Yulong Wu
Summary: A series of coated non-noble metal porous carbon catalysts were synthesized and applied to the aqueous-phase deoxygenation of algal bio-oil. One of the catalysts showed excellent deoxygenation selectivity and catalytic activity at 250 degrees C. The catalyst exhibited good hydrothermal stability and the reaction mechanism was proposed based on product analysis and active site analysis.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
M. V. Chudakova, M. V. Popov, P. A. Korovchenko, E. O. Pentsak, A. R. Latypova, P. B. Kurmashov, A. A. Pimenov, E. A. Tsilimbaeva, I. S. Levin, A. G. Bannov, A. V. Kleymenov
Summary: A series of catalysts with different potassium contents were prepared using solution combustion synthesis and characterized using various techniques. The results showed that the potassium content affected the phase composition and texture of the catalysts. The addition of a small amount of potassium resulted in a change in particle size distribution, leading to higher hydrogen yield. The Ni-1%K2O/Al2O3 catalyst exhibited the highest hydrogen yield at temperatures of 675 and 750 degrees Celsius.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Aliakbar Roosta, Nima Rezaei
Summary: In this study, we modified the electrolyte cubic plus association equation of state (e-CPA EoS) and integrated it with two electrical conductivity models to estimate the electrical conductivity of 11 monovalent electrolyte solutions in water. The modified e-CPA model demonstrated better performance and the hybridization with electrical conductivity models resulted in two predictive models for estimating the electrical conduction of dilute and concentrated electrolyte solutions. These predictive models showed relative average percentage deviations (AARD) of 11.15% and 13.87% over wide ranges of temperature and electrolyte concentration.
CHEMICAL ENGINEERING SCIENCE
(2024)
Article
Engineering, Chemical
Haoren Niu, Jianzheng Wang, Qingzhu Jia, Qiang Wang, Jin Zhao, Fangyou Yan
Summary: A study developed two quantitative structure-property relationship models for the complexation performance of alpha- and beta-cyclodextrins and validated their stability and predictive ability through internal and external validation. The models showed robustness and satisfactory performance, as demonstrated by the experimental results and model validations. These models can effectively predict the binding constants between cyclodextrins and various types of molecules, providing valuable tools for cyclodextrin design.
CHEMICAL ENGINEERING SCIENCE
(2024)
