Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Low dosage combination treatment with metformin and simvastatin inhibits obesity-promoted pancreatic cancer development in male KrasG12D mice
Authors
Keywords
-
Journal
Scientific Reports
Volume 13, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-09-27
DOI
10.1038/s41598-023-43498-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Cancer statistics, 2023
- (2023) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Statins and the risk of pancreatic cancer: A systematic review and meta-analysis of 2,797,186 patients
- (2022) Eryka Karbowska et al. Cardiology Journal
- Burden of pancreatic cancer along with attributable risk factors in Europe between 1990 and 2019, and projections until 2039
- (2021) Jingru Yu et al. INTERNATIONAL JOURNAL OF CANCER
- Metformin: review of epidemiology and mechanisms of action in pancreatic cancer
- (2021) Guido Eibl et al. CANCER AND METASTASIS REVIEWS
- Efficacy and Side Effect Profile of Different Formulations of Metformin: A Systematic Review and Meta-Analysis
- (2021) Jane L. Tarry-Adkins et al. Diabetes Therapy
- Sex Differences in Adverse Drug Reactions of Metformin: A Longitudinal Survey Study
- (2020) Sieta T. de Vries et al. DRUG SAFETY
- Metformin suppresses proliferation and invasion of drug‐resistant breast cancer cells by activation of the Hippo pathway
- (2020) Jie Liu et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma
- (2020) Christopher A. Natale et al. Cellular and Molecular Gastroenterology and Hepatology
- Metformin inhibits mTOR and c-Myc by decreasing YAP protein expression in OSCC cells
- (2020) Ying Wang et al. ONCOLOGY REPORTS
- Statin Use and Risk of Pancreatic Cancer
- (2019) Yun Zhang et al. PANCREAS
- New insights into YAP/TAZ nucleo‐cytoplasmic shuttling: new cancer therapeutic opportunities?
- (2019) Michal Shreberk‐Shaked et al. Molecular Oncology
- Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development
- (2019) Enrique Roz3engurt et al. WORLD JOURNAL OF GASTROENTEROLOGY
- Lipophilic statins inhibit YAP nuclear localization, co-activator activity and colony formation in pancreatic cancer cells and prevent the initial stages of pancreatic ductal adenocarcinoma in KrasG12D mice
- (2019) Fang Hao et al. PLoS One
- Metformin Alters the Duodenal Microbiome and Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity
- (2019) Tien S Dong et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Combination simvastatin and metformin synergistically inhibits endometrial cancer cell growth
- (2019) Josephine S. Kim et al. GYNECOLOGIC ONCOLOGY
- Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells
- (2019) Yanju Wu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- The Potential Effect of Metformin on Cancer: An Umbrella Review
- (2019) Hong Yu et al. Frontiers in Endocrinology
- Yes-Associated Protein 1 Plays Major Roles in Pancreatic Stellate Cell Activation and Fibroinflammatory Responses
- (2019) Cheng Hu et al. Frontiers in Physiology
- Metformin Decreases the Incidence of Pancreatic Ductal Adenocarcinoma Promoted by Diet-induced Obesity in the Conditional KrasG12D Mouse Model
- (2018) Hui-Hua Chang et al. Scientific Reports
- Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer
- (2018) Guido Eibl et al. Journal of the Academy of Nutrition and Dietetics
- Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells
- (2017) Fang Hao et al. MOLECULAR CANCER RESEARCH
- KRAS, YAP, and obesity in pancreatic cancer: A signaling network with multiple loops
- (2017) Guido Eibl et al. SEMINARS IN CANCER BIOLOGY
- Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
- (2017) Hui-Hua Chang et al. PLoS One
- QuPath: Open source software for digital pathology image analysis
- (2017) Peter Bankhead et al. Scientific Reports
- Cancer Prevention and Interception: A New Era for Chemopreventive Approaches
- (2016) A. Albini et al. CLINICAL CANCER RESEARCH
- YAP1 and TAZ Control Pancreatic Cancer Initiation in Mice by Direct Up-regulation of JAK–STAT3 Signaling
- (2016) Ralph Gruber et al. GASTROENTEROLOGY
- Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer
- (2015) Fa-Xing Yu et al. CELL
- Estrogen regulates Hippo signaling via GPER in breast cancer
- (2015) Xin Zhou et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of YAP and TAZ in pancreatic ductal adenocarcinoma and in stellate cells associated with cancer and chronic pancreatitis
- (2015) Susan Morvaridi et al. Scientific Reports
- Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages
- (2015) Joao Incio et al. PLoS One
- Synergistic Simvastatin and Metformin Combination Chemotherapy for Osseous Metastatic Castration-Resistant Prostate Cancer
- (2014) M. A. Babcook et al. MOLECULAR CANCER THERAPEUTICS
- Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells
- (2014) Ming Ming et al. PLoS One
- Cancer statistics, 2013
- (2013) Rebecca Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Association of metformin use with cancer incidence and mortality: A meta-analysis
- (2013) Pengpeng Zhang et al. Cancer Epidemiology
- High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model
- (2013) D. W. Dawson et al. Cancer Prevention Research
- Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK
- (2012) James Sinnett-Smith et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Statin Use as a Moderator of Metformin Effect on Risk for Prostate Cancer Among Type 2 Diabetic Patients
- (2012) D. M. Lehman et al. DIABETES CARE
- Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
- (2010) A. DeCensi et al. Cancer Prevention Research
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started