Article
Biochemistry & Molecular Biology
Wenying Yang, Dalong Zhu, Shenglian Gan, Xiaolin Dong, Junping Su, Wenhui Li, Hongwei Jiang, Wenjuan Zhao, Minxiu Yao, Weihong Song, Yibing Lu, Xiuzhen Zhang, Huifang Li, Guixia Wang, Wei Qiu, Guoyue Yuan, Jianhua Ma, Wei Li, Ziling Li, Xiaoyue Wang, Jiao'e Zeng, Zhou Yang, Jingdong Liu, Yongqian Liang, Song Lu, Huili Zhang, Hui Liu, Ping Liu, Kuanlu Fan, Xiaozhen Jiang, Yufeng Li, Qing Su, Tao Ning, Huiwen Tan, Zhenmei An, Zhaoshun Jiang, Lijun Liu, Zunhai Zhou, Qiu Zhang, Xuefeng Li, Zhongyan Shan, Yaoming Xue, Hong Mao, Lixin Shi, Shandong Ye, Xiaomei Zhang, Jiao Sun, Ping Li, Tao Yang, Feng Li, Jingna Lin, Zhinong Zhang, Ying Zhao, Ruonan Li, Xiaohui Guo, Qi Yao, Weiping Lu, Shen Qu, Hongmei Li, Liling Tan, Wenbo Wang, Yongli Yao, Daoxiong Chen, Yulan Li, Jialin Gao, Wen Hu, Xiaoqiang Fei, Tianfeng Wu, Song Dong, Wenlong Jin, Chenzhong Li, Dong Zhao, Bo Feng, Yu Zhao, Yi Zhang, Xiaoying Li, Li Chen
Summary: In patients with inadequate glycemic control using metformin alone, dorzagliatin as an add-on therapy resulted in effective glycemic control with good tolerability and safety.
Article
Endocrinology & Metabolism
Soo Heon Kwak, Kyung Ah Han, Kyung-Soo Kim, Jae Myung Yu, EunSook Kim, Jong Chul Won, Jun Goo Kang, Choon Hee Chung, Seungjoon Oh, Sung Hee Choi, Kyu Chang Won, Sin Gon Kim, Seung Ah Cho, Bo Young Cho, Kyong Soo Park
Summary: This study evaluated the efficacy and safety of enavogliflozin 0.3 mg as a monotherapy for Korean patients with inadequately controlled type 2 diabetes through diet and exercise. The results showed that enavogliflozin 0.3 mg improved glycemic control in patients with T2DM, and also had beneficial effects on body weight, blood pressure, and lipid profile.
DIABETES OBESITY & METABOLISM
(2023)
Article
Clinical Neurology
Karin Ried, Tasnuva Tamanna, Sonja Matthews, Avni Sali
Summary: This study aimed to assess the tolerability and effectiveness of Entoura-10:15 medicinal cannabis oil on sleep in adults with insomnia. The results showed that the medicinal cannabis oil was well tolerated and effective in improving sleep.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Nutrition & Dietetics
Dante Xing, Choongsung Yoo, Drew Gonzalez, Victoria Jenkins, Kay Nottingham, Broderick Dickerson, Megan Leonard, Joungbo Ko, Mark Faries, Wesley Kephart, Martin Purpura, Ralf Jaeger, Shawn D. Wells, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider
Summary: The study investigated the effects of varying doses of PXN on cognitive function and side effects, finding that acute ingestion of 100 mg and 200 mg of PXN may affect measures of cognition, memory, reasoning, and response time. Additionally, daily ingestion of PXN for 7 days was not associated with any clinically significant side effects, suggesting PXN may serve as an effective nootropic agent at doses as low as 50 mg.
Article
Endocrinology & Metabolism
Casper K. Nielsen, Caroline C. Ohrstrom, Urd L. Kielgast, Dorte L. Hansen, Bolette Hartmann, Jens J. Holst, Asger Lund, Tina Vilsboll, Filip K. Knop
Summary: This study investigated the efficacy and safety of a novel stable glucagon analog, dasiglucagon, in individuals who had undergone Roux-en-Y gastric bypass (RYGB) and suffered from postbariatric hypoglycemia (PBH). The results demonstrated that a single-dose administration of dasiglucagon effectively mitigated postprandial hypoglycemia.
Article
Biochemistry & Molecular Biology
Stephen A. Harrison, Federico Perez Manghi, William B. Smith, Diana Alpenidze, Diego Aizenberg, Naomi Klarenbeek, Chi-Yi Chen, Eli Zuckerman, Eric Ravussin, Phunchai Charatcharoenwitthaya, Pin-Nan Cheng, Helena Katchman, Samuel Klein, Ziv Ben-Ari, Anisha E. Mendonza, Yiming Zhang, Miljen Martic, Shenglin Ma, Sheena Kao, Sandra Tanner, Alok Pachori, Michael K. Badman, YanLing He, Chinweike Ukomadu, Eric Sicard
Summary: In patients with nonalcoholic steatohepatitis (NASH), the use of licogliflozin led to reductions in serum alanine aminotransferase levels, suggesting it could be a potential therapeutic option. However, further studies are needed to validate these findings and evaluate its combination with other drugs.
Article
Nutrition & Dietetics
Stine B. Smedegaard, Maike Mose, Adam Hulman, Ulla R. Mikkelsen, Niels Moller, Gregers Wegener, Niels Jessen, Nikolaj Rittig
Summary: The study found that beta-lactoglobulin (BLG) in whey protein elevates insulin, glucagon, and glucose concentrations in patients with type 2 diabetes mellitus compared to whey protein isolate (WPI), but WPI remains the most effective in lowering postprandial glucose excursions.
Article
Endocrinology & Metabolism
Soumita Mandal, Pradip Mukhopadhyay, Sujoy Ghosh
Summary: This study aimed to investigate the use of DHEA supplementation in patients with Sheehan syndrome (SS). The results showed that DHEA supplementation significantly improved the Female Sexual Functioning Index (FSFI) score, with significant improvements in both FSFI score and individual domains of female sexual dysfunction (FSD). Furthermore, DHEA treatment did not result in any metabolic side effects.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Health Care Sciences & Services
Wagner Martorina, Almir Tavares
Summary: This study aims to investigate the effect of melatonin replacement on insulin secretion rhythms and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM), ultimately reducing glycemic variability. The study uses a crossover, randomized, double-blind, placebo-controlled trial design with 30 participants. The results will provide valuable insights into the potential of melatonin supplementation in T2DM management.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Amy A. Gelfand, I. Elaine Allen, Barbara Grimes, Samantha Irwin, William Qubty, Kaitlin Greene, Maggie Waung, Scott W. Powers, Christina L. Szperka
Summary: This is a randomized double-blind trial investigating the efficacy of melatonin for migraine prevention in children and adolescents. The results did not show any significant superiority of melatonin compared to placebo, but due to substantial missing data, it cannot be concluded that melatonin is ineffective. Future preventive trials in this age group may benefit from using a single-blind placebo run-in and enriching for participants already on a migraine preventive.
Article
Medicine, Research & Experimental
Hadi Bazyar, Ahmad Zare Javid, Hossein Bavi Behbahani, Fardin Moradi, Bahman Moradi Poode, Parichehr Amiri
Summary: The study illustrates that melatonin supplementation has a positive effect on cardiovascular disease risk factors and anthropometric indices in patients with type 2 diabetes mellitus, showing effectiveness in controlling arterial pressure, including SBP, MAP, and PP, as well as predicting obesity indicators.
Article
Chemistry, Medicinal
Saeid Hadi, Reza Daryabeygi-Khotbehsara, Parvin Mirmiran, Jenna McVicar, Vahid Hadi, Davood Soleimani, Gholamreza Askari
Summary: The study demonstrated that Nigella sativa oil extract had beneficial effects on glycemic control, serum lipid profile, blood pressure, and body weight among people with type 2 diabetes. Further long-term trials are needed to confirm the therapeutic benefits of Nigella sativa in T2D.
PHYTOTHERAPY RESEARCH
(2021)
Article
Nutrition & Dietetics
Jemima S. A. Dzator, Peter R. C. Howe, Kirsten G. Coupland, Rachel H. X. Wong
Summary: This study aimed to investigate the effects of resveratrol on hormonal migraineurs. After three months of supplementation, it was found that resveratrol did not improve the burden index, migraine-related disability, or quality of life in this cohort of hormonal migraineurs.
Article
Endocrinology & Metabolism
Julie Dubourg, Pascale Fouqueray, Carole Thang, Jean-Marie Grouin, Kohjiro Ueki
Summary: The study demonstrated that imeglimin significantly improved HbA(1c) levels in Japanese patients with type 2 diabetes compared to placebo, and had a similar safety profile to placebo. Imeglimin represents a potential new treatment option for this population.
Article
Endocrinology & Metabolism
Katrine M. Lauritsen, Bent R. R. Nielsen, Lars P. Tolbod, Mogens Johannsen, Jakob Hansen, Troels K. Hansen, Henrik Wiggers, Niels Moller, Lars C. Gormsen, Esben Sondergaard
Summary: SGLT2 inhibition in individuals with type 2 diabetes did not affect myocardial fatty acid uptake, but decreased myocardial glucose uptake and resting myocardial blood flow. These metabolic and hemodynamic changes were modest and likely only partially contribute to the cardioprotective effect of SGLT2 inhibition.
Letter
Behavioral Sciences
Almir Tavares, Fernando Madalena Volpe
Letter
Clinical Neurology
Fernando Madalena Volpe, Almir Ribeiro Tavares
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
(2012)
Article
Clinical Neurology
C. M. Roe, A. L. Fitzpatrick, C. Xiong, W. Sieh, L. Kuller, J. P. Miller, M. M. Williams, R. Kopan, M. I. Behrens, J. C. Morris
Letter
Medicine, General & Internal
Almir R. Tavares
NEW ENGLAND JOURNAL OF MEDICINE
(2013)
Letter
Psychiatry
Almir Ribeiro Tavares, Fernando Madalena Volpe
REVISTA BRASILEIRA DE PSIQUIATRIA
(2010)
Article
Endocrinology & Metabolism
Wagner Martorina, Almir Tavares
JOURNAL OF DIABETES RESEARCH
(2019)
Article
Clinical Neurology
Luciano F. Drager, Daniela Pachito, Claudia R. C. Moreno, Almir R. Tavares, Silvia G. Conway, Marcia Assis, Danilo A. Sguillar, Gustavo A. Moreira, Andrea Bacelar, Pedro R. Genta
Summary: The COVID-19 pandemic has had a significant impact on insomnia and other sleep disturbances in healthcare professionals. Factors such as age, gender, anxiety, and burnout are associated with the onset or worsening of insomnia.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Medicine, General & Internal
Wagner Jose Martorina, Almir Tavares
Summary: COVID-19 infection is more severe in patients with type 2 diabetes mellitus due to intense inflammatory activity. Systemic inflammation in these patients is exacerbated by hyperglycemia, sleep disorders, and low levels of melatonin. Exogenous melatonin may play a crucial anti-inflammatory role in preventing severe forms of COVID-19 in patients with DM2.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
Article
Health Care Sciences & Services
Wagner Martorina, Almir Tavares
Summary: This study aims to investigate the effect of melatonin replacement on insulin secretion rhythms and insulin sensitivity in patients with type 2 diabetes mellitus (T2DM), ultimately reducing glycemic variability. The study uses a crossover, randomized, double-blind, placebo-controlled trial design with 30 participants. The results will provide valuable insights into the potential of melatonin supplementation in T2DM management.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Clinical Neurology
Claudia Roberta de Castro Moreno, Silvia G. Conway, Marcia Assis, Pedro Rodrigues Genta, Daniela Pachito, Almir Tavares-Jr, Danilo A. Sguillar, Gustavo Moreira, Luciano F. Drager, Andrea Bacelar
Summary: This study investigated sleep-related and mental health symptoms before and during the COVID-19 pandemic in a national-wide sample. The results showed that 70% of participants reported sleep disturbances and 80% reported symptoms of anxiety during the pandemic. However, only one third of them sought help. The study also found a decrease in sleep duration and an increase in difficulties falling asleep.
Letter
Behavioral Sciences
Fernando Madalena Volpe, Almir Ribeiro Tavares
Letter
Medicine, General & Internal
Almir R. Tavares, Claudia P. Caciquinho Vieira, Pedro A. Macedo Souza
NEW ENGLAND JOURNAL OF MEDICINE
(2011)
Letter
Medicine, General & Internal
Aine Burns, Andrew Davenport
NEW ENGLAND JOURNAL OF MEDICINE
(2010)
Letter
Medicine, General & Internal
Almir R. Tavares, Claudia P. Caciquinho Vieira, Pedro A. Macedo Souza
NEW ENGLAND JOURNAL OF MEDICINE
(2010)