Beta cell primary cilia mediate somatostatin responsiveness via SSTR3

Rediscovering Primary Cilia in Pancreatic Islets

(2023) Eun Young Lee et al.   Diabetes & Metabolism Journal

ZT ‐01: A novel somatostatin receptor 2 antagonist for restoring the glucagon response to hypoglycaemia in type 1 diabetes

(2022) Rawad Farhat et al.   DIABETES OBESITY & METABOLISM

Liraglutide increases islet Ca 2+ oscillation frequency and insulin secretion by activating hyperpolarization‐activated cyclic nucleotide‐gated channels

(2022) Karolina E. Zaborska et al.   DIABETES OBESITY & METABOLISM

Cilia Action in Islets: Lessons From Mouse Models

(2022) Jung Hoon Cho et al.   Frontiers in Endocrinology

Gi/o protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na+/K+ ATPase activation

(2022) Matthew T. Dickerson et al.   Nature Communications

Islet primary cilia motility controls insulin secretion

(2022) Jung Hoon Cho et al.   Science Advances

The β-cell primary cilium is an autonomous Ca2+ compartment for paracrine GABA signaling

(2022) Gonzalo Manuel Sanchez et al.   JOURNAL OF CELL BIOLOGY

Islet cilia and glucose homeostasis

(2022) Isabella Melena et al.   Frontiers in Cell and Developmental Biology

Transdermal delivery of a somatostatin receptor type 2 antagonist using microneedle patch technology for hypoglycemia prevention

(2021) Amin GhavamiNejad et al.   Drug Delivery and Translational Research

The Effect of 6 Months’ Treatment With Pasireotide LAR on Glucose Metabolism in Patients With Resistant Acromegaly in Real-World Clinical Settings

(2021) Przemysław Witek et al.   Frontiers in Endocrinology

Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion

(2021) Chien-Ting Wu et al.   GENES & DEVELOPMENT

Role of High Voltage-Gated Ca2+ Channel Subunits in Pancreatic β-Cell Insulin Release. From Structure to Function

(2021) Petronel Tuluc et al.   Cells

Primary cilia control glucose homeostasis via islet paracrine interactions

(2020) Jing W. Hughes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention

(2020) Annie R. Piñeros et al.   Metabolites

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP)

(2019) Klaus H. Kaestner et al.   DIABETES

Direct visualization of cAMP signaling in primary cilia reveals up-regulation of ciliary GPCR activity following Hedgehog activation

(2019) Jason Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intact pancreatic islets and dispersed beta-cells both generate intracellular calcium oscillations but differ in their responsiveness to glucose

(2019) Rachel T. Scarl et al.   CELL CALCIUM

Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium

(2018) Xiaowen Liu et al.   eLife

The primary cilium as a cellular receiver: organizing ciliary GPCR signaling

(2016) Keren I Hilgendorf et al.   CURRENT OPINION IN CELL BIOLOGY

Hyperglycemia induced by pasireotide in patients with Cushing’s disease or acromegaly

(2016) Julie M. Silverstein   Pituitary

Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics

(2016) Bryn S. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Potential and Calcium Dynamics in Beta Cells from Mouse Pancreas Tissue Slices: Theory, Experimentation, and Analysis

(2015) Jurij Dolenšek et al.   SENSORS

Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes

(2015) Shrenik K. Shah et al.   ACS Medicinal Chemistry Letters

L-type calcium channel modulates cystic kidney phenotype

(2014) Xingjian Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Somatostatin receptor subtype 4 modulates L-type calcium channels via Gβγ and PKC signaling in rat retinal ganglion cells

(2014) Spring R Farrell et al.   Channels

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents

(2014) Jantje M. Gerdes et al.   Nature Communications

Somatostatin Receptor Type 2 Antagonism Improves Glucagon Counterregulation in Biobreeding Diabetic Rats

(2013) Negar Karimian et al.   DIABETES

Ultrasensitive fluorescent proteins for imaging neuronal activity

(2013) Tsai-Wen Chen et al.   NATURE

SSTR2 is the functionally dominant somatostatin receptor in human pancreatic β- and α-cells

(2012) Balrik Kailey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes

(2012) Shuwen He et al.   ACS Medicinal Chemistry Letters

Restricted expression of somatostatin receptor 3 to primary cilia in the pancreatic islets and adenohypophysis of mice

(2011) Toshihiko Iwanaga et al.   BIOMEDICAL RESEARCH-TOKYO

Gap junctions and other mechanisms of cell-cell communication regulate basal insulin secretion in the pancreatic islet

(2011) R. K. P. Benninger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Somatostatin Receptor Subtypes in Human Type 2 Diabetic Islets

(2010) Guida M. Portela-Gomes et al.   PANCREAS

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibitory Effect of Somatostatin-14 on L-Type Voltage-Gated Calcium Channels in Cultured Cone Photoreceptors Requires Intracellular Calcium

(2009) Kuihuan Jian et al.   JOURNAL OF NEUROPHYSIOLOGY

Somatostatin Secreted by Islet  -Cells Fulfills Multiple Roles as a Paracrine Regulator of Islet Function

(2008) A. C. Hauge-Evans et al.   DIABETES

Voltage-Gated Ion Channels in Human Pancreatic  -Cells: Electrophysiological Characterization and Role in Insulin Secretion

(2008) M. Braun et al.   DIABETES

Oscillatory control of insulin secretion

(2008) A TENGHOLM et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-coupled Receptors

(2008) Nicolas F. Berbari et al.   MOLECULAR BIOLOGY OF THE CELL