Journal
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
Volume -, Issue -, Pages -Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/15347346231210709
Keywords
revascularization; wound management; wound healing; redox; stem cells; mitochondria
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Wound healing involves a complex series of cellular and molecular events, and revascularization is a crucial step in this process. Adequate blood flow restoration is recognized as necessary for successful tissue regeneration. Stem cells play a key role in regulating other repair cells and matrix formation during the later stage of revascularization and tissue remodeling in wound healing. The REDOX state, potentially influenced by stem/progenitor cells, may be a key mechanism for endothelial cell maturation and improving the quality of healing. Mitochondria are likely to have an important role in this process.
Wound healing is a complex and dynamic process involving a series of cellular and molecular events. Revascularization, the restoration of blood flow to ischemic or damaged tissue, is a key step in wound healing. Adequate vascularization has been recognized as a necessary factor for successful tissue regeneration. In the later stage of revascularization and tissue remodeling in wound healing, stem cells regulate other repair cells and matrix formation by influencing the maturation of blood vessels. The reductive oxidation (REDOX) state may be a key mechanism through stem/progenitor cells to influence endothelial cells to mature blood vessels and improve the quality of healing. Mitochondria may play an important role in this process.
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