Article
Radiology, Nuclear Medicine & Medical Imaging
Antonio Orlacchio, Carlo Guastoni, Giordano Domenico Beretta, Laura Cosmai, Michele Galluzzo, Stefania Gori, Emanuele Grassedonio, Lorena Incorvaia, Carmelita Marcantoni, Giuseppe Stefano Netti, Matteo Passamonti, Camillo Porta, Giuseppe Procopio, Mimma Rizzo, Silvia Roma, Laura Romanini, Fulvio Stacul, Alice Casinelli
Summary: The increasing number of examinations and interventional radiological procedures requiring contrast medium administration highlights the problem of CM-induced renal toxicity in patients at risk. This position paper provides guidelines for clinicians to manage CM-related renal dysfunction, emphasizing the importance of assessing renal function through eGFR measurement and defining cutoff values for renal risk. Intravenous hydration and preventive measures are recommended for patients at risk.
Article
Urology & Nephrology
Bethany C. Birkelo, Neesh Pannu, Edward D. Siew
Summary: This article chronicles the evolution of attempts to classify AKI, including the adoption of consensus definitions, the expansion of diagnosis and prognosis with novel biomarkers, and the application of emerging tools such as artificial intelligence (AI).
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Oncology
Kim T. Vuong, Catherine Joseph, Joseph R. Angelo
Summary: While AKI after HCT is well-described in pediatric patients, limited literature exists regarding the long-term renal consequences, development of CKD, and CKD care in these patients. CKD affects almost 50% of patients after HCT with various causes, and as renal function declines, mortality increases. This review aims to summarize definitions, etiologies, and management strategies for AKI and CKD post-HCT, with a focus on early identification, intervention, and discussion of ESKD and renal transplant.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Abby Basalely, Shari Gurusinghe, James Schneider, Sareen S. Shah, Linda B. Siegel, Gabrielle Pollack, Pamela Singer, Laura J. Castellanos-Reyes, Steven Fishbane, Kenar D. Jhaveri, Elizabeth Mitchell, Kumail Merchant, Christine Capone, Ashley M. Gefen, Julie Steinberg, Christine B. Sethna
Summary: This study found a high incidence of acute kidney injury in patients with COVID-19 and MIS-C, with associations to lower serum albumin levels and higher white blood cell counts, suggesting a link to inflammation and dehydration.
KIDNEY INTERNATIONAL
(2021)
Editorial Material
Oncology
Kosuke Sawami, Atsushi Tanaka, Koichi Node
Summary: Cancer therapies can have adverse effects on the cardiovascular system, particularly through vascular toxic effects that lead to vascular complications. However, the lack of fully established screening and predictive methods means that these vascular complications are usually managed after they occur.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Surgery
Chase Wilson, Carrie L. Phillips, Alison Klenk, Matthew Kuhar, Muhammad S. Yaqub
Summary: A rare case of crystalglobulinemia causing cutaneous vasculopathy and acute nephropathy was presented in a 66-year-old female kidney transplant recipient. Treatment with bortezomib and dexamethasone led to improvement in acute kidney injury and cutaneous vasculopathy. This case highlights the importance of early detection and management of crystalglobulin-induced complications in transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Shruti Gupta, Prakash Gudsoorkar, Kenar D. Jhaveri
Summary: Critically ill cancer patients have a higher incidence of acute kidney injury treated with renal replacement therapy. Acute kidney injury can be a direct or indirect result of cancer itself, its treatment, or complications. Recent studies show that having an underlying cancer is no longer a contraindication for initiating renal replacement therapy or advanced life-supportive measures. However, these results should not be used to justify unrealistic perseverance or deny palliative care in desperate cancer patients. The decision to initiate advanced therapy should consider the patient's long-term prognosis and quality of life.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Michael L. Behal, Alexander H. Flannery, Erin F. Barreto
Summary: AKI often occurs in critically ill patients. Patients with AKI, including those who require KRT, experience dynamic changes in medication effectiveness and safety due to multiple pharmacokinetic and pharmacodynamic perturbations. Conventional GFR estimation equations based on serum creatinine have limitations for accurate medication dosing in critically ill patients with AKI. Alternative methods, such as urinary creatinine clearance, kinetic eGFR, and equations incorporating novel kidney biomarkers, may provide informative estimates of kidney function. For critically ill patients with AKI requiring KRT, factors including drug properties, KRT prescription and circuit configuration, and patient-specific factors all contribute to medication clearance.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Oncology
Bruce C. Tiu, Ian A. Strohbehn, Sophia Zhao, Tianqi Ouyang, Paul Hanna, Qiyu Wang, Shruti Gupta, David E. Leaf, Kerry L. Reynolds, Meghan E. Sise
Summary: In patients with advanced CKD, ICIs are not associated with an increased risk of AKI or new-onset kidney failure compared with other antineoplastic therapies. However, patients with advanced CKD who received ICIs had a lower overall survival compared with patients with eGFR >= 30 mL/minute/1.73 m(2).
Article
Oncology
Bruce C. Tiu, Ian A. Strohbehn, Sophia Zhao, Tianqi Ouyang, Paul Hanna, Qiyu Wang, Shruti Gupta, David E. Leaf, Kerry L. Reynolds, Meghan E. Sise
Summary: This study investigates the safety of immune checkpoint inhibitor therapy in patients with advanced chronic kidney disease (CKD) and cancer. The results show that ICIs do not increase the risk of kidney failure or acute kidney injury (AKI) compared to other antineoplastic therapies in patients with advanced CKD. However, these patients experience lower overall survival.
Article
Transplantation
Raymond Vanholder, Eric Rondeau, Hans-Joachim Anders, Nicholas Carlson, Danilo Fliser, Mehmet Kanbay, Jose Antonio Lopes, Patrick T. Murray, Alberto Ortiz, Ana B. Sanz, Nicholas M. Selby, Andrzej Wiecek, Ziad A. Massy
Summary: The article highlights the importance of acute kidney injury (AKI) in clinical nephrology and the need to improve European nephrology's contribution in this field. It identifies a lower scientific output in Europe compared to countries with a comparable socio-economic status, and proposes a model for promoting clinical collaboration on AKI across Europe and enhancing research and funding in this area.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Pediatrics
Sidse Hoyer, Uffe Heide-Jorgensen, Simon Kok Jensen, Mette Norgaard, Cara Slagle, Stuart Goldstein, Christian Fynbo Christiansen
Summary: This study aimed to examine the annual rate of acute kidney injury (AKI) and associated changes in patient characteristics among Danish children. The study found that the rate of AKI among Danish children remained stable from 2007 to 2021, with little variation in patient characteristics over time.
PEDIATRIC NEPHROLOGY
(2023)
Article
Oncology
Semin Cho, Eunjeong Kang, Ji Eun Kim, U. Kang, Hee Gyung Kang, Minsu Park, Kwangsoo Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Hyung-Jin Yoon, Hajeong Lee
Summary: This study found that more than half of lung cancer patients experience AKI during their diagnosis and treatment period. The occurrence of AKI and more advanced AKI are associated with a higher risk of mortality and adverse kidney outcomes.
CANCER RESEARCH AND TREATMENT
(2021)
Article
Urology & Nephrology
Maggie Tso, Kamal Sud, Connie Van, Wubshet Tesfaye, Ronald L. Castelino
Summary: This retrospective study analyzed the clinical characteristics of patients with CA-AKI and the impact of nephrology interventions on outcomes. The results showed that younger age and higher admission/discharge serum creatinine were associated with nephrology consultations, but nephrology consultations did not have any impact on outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Hematology
Rupesh Raina, Zubin A. Mahajan, Prabhav Vasistha, Ronith Chakraborty, Krishna Mukunda, Abhishek Tibrewal, Javier A. Neyra
Summary: This comprehensive systematic review on AKI in COVID-19 patients found a high incidence of AKI and a relatively high proportion of patients requiring KRT in the COVID-19 population. The mortality rate was significantly higher among AKI patients compared to the overall COVID-19 patient population.
BLOOD PURIFICATION
(2022)
Review
Oncology
Gilbert Deray, Nicolas Janus, Blandine Aloy, Vincent Launay-Vacher
BULLETIN DU CANCER
(2016)
Meeting Abstract
Oncology
V. Launay-Vacher, N. Janus, I. Ray-Coquard, J. Thariat, G. Deray, P. Beuzeboc
Article
Biochemistry & Molecular Biology
Mihaela Babiceanu, Fujun Qin, Zhongqiu Xie, Yuemeng Jia, Kevin Lopez, Nick Janus, Loryn Facemire, Shailesh Kumar, Yuwei Pang, Yanjun Qi, Iulia M. Lazar, Hui Li
NUCLEIC ACIDS RESEARCH
(2016)
Article
Oncology
Vincent Launay-Vacher, Nicolas Janus, Gilbert Deray, Florian Scotte
SUPPORTIVE CARE IN CANCER
(2016)
Review
Biochemistry & Molecular Biology
Nicolas Janus, Vincent Launay-Vacher
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2017)
Article
Urology & Nephrology
Nicolas Janus, Vincent Launay-Vacher, Gilbert Deray
NEPHROLOGIE & THERAPEUTIQUE
(2018)
Article
Oncology
Corinne Frere, Benjamin Crichi, Manon Lejeune, Jean-Philippe Spano, Nicolas Janus
Article
Urology & Nephrology
Blandine Aloy, Nicolas Janus, Corine Isnard-Bagnis, Gilbert Deray, Vincent Launay-Vacher
Summary: The renal toxicity of anticancer drugs is a clinical challenge due to the intrinsic toxicity of some drugs and the various renal disorders cancer patients may experience. Improving safety requires better dose adjustment based on correct evaluation of renal function, and prevention is important due to the high mortality associated with acute renal failure.
NEPHROLOGIE & THERAPEUTIQUE
(2021)
Review
Oncology
Corinne Frere, Carme Font, Francis Esposito, Benjamin Crichi, Philippe Girard, Nicolas Janus
Summary: This study summarizes the risk of bleeding complications in anticoagulant treatment for cancer-associated thrombosis, highlighting the importance of personalized matching of appropriate drugs and evaluation of patient medical history to assist clinicians in decision-making. It also emphasizes the need for clinicians to be aware of specific factors in patients that may exacerbate the overall bleeding risk.
SUPPORTIVE CARE IN CANCER
(2022)
Meeting Abstract
Hematology
I. Elalamy, N. Janus
THROMBOSIS RESEARCH
(2021)
Meeting Abstract
Hematology
Nicolas Janus
Meeting Abstract
Hematology
Nicolas Janus
Article
Urology & Nephrology
Nicolas Janus, Vincent Launay-Vacher, Laurent Juillard, Gilbert Deray, Thierry Hannedouche, Myriam Isnard-Rouchon, Stephane Burtey, Philippe Vanhille, Jean-Paul Ortiz, Gerard Janin, Philippe Nicoud, Malik Touam, Maurice Laville
CLINICAL KIDNEY JOURNAL
(2017)
Review
Immunology
Blandine Aloy, Imane Tazi, Corinne Isnard Bagnis, Marion Gauthier, Nicolas Janus, Vincent Launay-Vacher, Gilbert Deray, Jerome Tourret
