High-plex spatial transcriptomic profiling reveals distinct immune components and the HLA class I/DNMT3A/CD8 modulatory axis in mismatch repair-deficient endometrial cancer

Reducing the complexity of high-dimensional environmental data: An analytical framework using LASSO with considerations of confounding for statistical inference

(2023) Seth Frndak et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

(2022) Emeric Limagne et al.   CANCER CELL

Pembrolizumab in Patients With Microsatellite Instability–High Advanced Endometrial Cancer: Results From the KEYNOTE-158 Study

(2022) David M. O'Malley et al.   JOURNAL OF CLINICAL ONCOLOGY

Advances in mixed cell deconvolution enable quantification of cell types in spatial transcriptomic data

(2022) Patrick Danaher et al.   Nature Communications

Selecting Genetic Variants and Interactions Associated with Amyotrophic Lateral Sclerosis: A Group LASSO Approach

(2022) Sofia Galvão Feronato et al.   Journal of Personalized Medicine

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation

(2021) Karthik Dhatchinamoorthy et al.   Frontiers in Immunology

POLE and Mismatch Repair Status, Checkpoint Proteins and Tumor-Infiltrating Lymphocytes in Combination, and Tumor Differentiation: Identify Endometrial Cancers for Immunotherapy

(2021) Dandan Dong et al.   Frontiers in Oncology

Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

(2021) Brooke Prinzing et al.   Science Translational Medicine

Endometrial cancer

(2021) Vicky Makker et al.   Nature Reviews Disease Primers

Multifaceted Roles of Chemokines and Chemokine Receptors in Tumor Immunity

(2021) Kazuhiko Matsuo et al.   Cancers

Multiplex digital spatial profiling of proteins and RNA in fixed tissue

(2020) Christopher R. Merritt et al.   NATURE BIOTECHNOLOGY

CC Chemokines in a Tumor: A Review of Pro-Cancer and Anti-Cancer Properties of Receptors CCR5, CCR6, CCR7, CCR8, CCR9, and CCR10 Ligands

(2020) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MHC class I loss in endometrial carcinoma: a potential resistance mechanism to immune checkpoint inhibition

(2020) Lisa A. Friedman et al.   MODERN PATHOLOGY

Clinical Activity and Safety of the Anti–Programmed Death 1 Monoclonal Antibody Dostarlimab for Patients With Recurrent or Advanced Mismatch Repair–Deficient Endometrial Cancer

(2020) Ana Oaknin et al.   JAMA Oncology

DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

(2020) Changzheng Lu et al.   CANCER CELL

Pembrolizumab in Microsatellite-Instability–High Advanced Colorectal Cancer

(2020) Thierry André et al.   NEW ENGLAND JOURNAL OF MEDICINE

Class I transactivator, NLRC5: a central player in the MHC class I pathway and cancer immune surveillance

(2019) Saptha Vijayan et al.   IMMUNOGENETICS

Proteogenomic Analysis of Human Colon Cancer Reveals New Therapeutic Opportunities

(2019) Suhas Vasaikar et al.   CELL

Genetic diversity of tumors with mismatch repair deficiency influences anti–PD-1 immunotherapy response

(2019) Rajarsi Mandal et al.   SCIENCE

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

(2019) Denarda Dangaj et al.   CANCER CELL

Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair–Deficient Cancer: Results From the Phase II KEYNOTE-158 Study

(2019) Aurelien Marabelle et al.   JOURNAL OF CLINICAL ONCOLOGY

An NRG Oncology/GOG study of molecular classification for risk prediction in endometrioid endometrial cancer

(2018) Casey M. Cosgrove et al.   GYNECOLOGIC ONCOLOGY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

(2018) Na Luo et al.   Nature Communications

Measuring associations between the microbiota and repeated measures of continuous clinical variables using a lasso-penalized generalized linear mixed model

(2018) Laura Tipton et al.   BioData Mining

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

Targeting Macrophage-Recruiting Chemokines as a Novel Therapeutic Strategy to Prevent the Progression of Solid Tumors

(2018) David Argyle et al.   Frontiers in Immunology

High and low mutational burden tumors versus immunologically hot and cold tumors and response to immune checkpoint inhibitors

(2018) Saman Maleki Vareki   Journal for ImmunoTherapy of Cancer

The Inflammatory CXC Chemokines, GROαhigh, IP-10low, and MIGlow, in Tumor Microenvironment Can Be Used as New Indicators for Non-small Cell Lung Cancer Progression

(2017) Ya Cao et al.   IMMUNOLOGICAL INVESTIGATIONS

Safety and Antitumor Activity of Pembrolizumab in Advanced Programmed Death Ligand 1–Positive Endometrial Cancer: Results From the KEYNOTE-028 Study

(2017) Patrick A. Ott et al.   JOURNAL OF CLINICAL ONCOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Mechanisms inE. coliand Human Mismatch Repair (Nobel Lecture)

(2016) Paul Modrich   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CXCL9 and CXCL10 predict survival and are regulated by cyclooxygenase inhibition in advanced serous ovarian cancer

(2016) Holger Bronger et al.   BRITISH JOURNAL OF CANCER

Facilitating T Cell Infiltration in Tumor Microenvironment Overcomes Resistance to PD-L1 Blockade

(2016) Haidong Tang et al.   CANCER CELL

A novel quantitative immunohistochemistry method for precise protein measurements directly in formalin-fixed, paraffin-embedded specimens: analytical performance measuring HER2

(2016) Kristian Jensen et al.   MODERN PATHOLOGY

Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases

(2016) Debbie M. Ferns et al.   Journal for ImmunoTherapy of Cancer

The role of CCL20/CCR6 axis in recruiting Treg cells to tumor sites of NSCLC patients

(2015) Chun-yang Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

A clinically applicable molecular-based classification for endometrial cancers

(2015) A Talhouk et al.   BRITISH JOURNAL OF CANCER

Multiple Structural and Epigenetic Defects in the Human Leukocyte Antigen Class I Antigen Presentation Pathway in a Recurrent Metastatic Melanoma Following Immunotherapy

(2015) Chien-Chung Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model

(2015) L. Wang et al.   Cancer Immunology Research

The de novo DNA methyltransferase DNMT3A in development and cancer

(2014) Bi-Feng Chen et al.   Epigenetics

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Protective Role of the Inflammatory CCR2/CCL2 Chemokine Pathway through Recruitment of Type 1 Cytotoxic    T Lymphocytes to Tumor Beds

(2013) T. Lanca et al.   JOURNAL OF IMMUNOLOGY

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

NLRC5: a newly discovered MHC class I transactivator (CITA)

(2011) Torsten B. Meissner et al.   MICROBES AND INFECTION

Selective Recruitment of Regulatory T Cell through CCR6-CCL20 in Hepatocellular Carcinoma Fosters Tumor Progression and Predicts Poor Prognosis

(2011) Kang-Jie Chen et al.   PLoS One

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

Depletion ofDNMT3ASuppressed Cell Proliferation and RestoredPTENin Hepatocellular Carcinoma Cell

(2010) Zhujiang Zhao et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An essential role for DNA methyltransferase 3a in melanoma tumorigenesis

(2009) Tao Deng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL