Article
Endocrinology & Metabolism
Tomoyo Itonaga, Masako Izawa, Takashi Hamajima, Yukihiro Hasegawa
Summary: This study explored the correlation between the first morning urinary pregnanetriol (PT) value and serum/blood 17-hydroxyprogesterone (17OHP) value at various time points. The results showed a significant positive correlation between the first morning PT value and 17OHP value before medication, suggesting that measuring the first morning PT value may be more practical and useful for monitoring 21-hydroxylase deficiency (21-OHD) biochemically.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Richard J. Auchus, Kyriakie Sarafoglou, Patricia Y. Fechner, Maria G. Vogiatzi, Erik A. Imel, Shanlee M. Davis, Nagdeep Giri, Julia Sturgeon, Eiry Roberts, Jean L. Chan, Robert H. Farber
Summary: This study examined the safety, tolerability, and efficacy of crinecerfont as a selective CRF1R antagonist in patients with 21OHD. The results showed that crinecerfont treatment for 14 days significantly reduced adrenal androgen production and improved clinical symptoms in patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Tomoyo Itonaga, Yukihiro Hasegawa
Summary: 21-hydroxylase deficiency (21-OHD) is the most common form of congenital adrenal hyperplasia. Newborn screening and genetic testing have improved the diagnosis of 21-OHD, but there are still challenges in treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jennifer L. Ng, Ee Mun Lim, Rui Zhang, John P. Beilby, Gerald F. Watts, Suzanne J. Brown, Bronwyn G. A. Stuckey
Summary: Liquid chromatography and tandem mass spectrometry (LC-MS/MS) can accurately differentiate nonclassic congenital adrenal hyperplasia (NCCAH) and polycystic ovary syndrome (PCOS) using measured 17-hydroxyprogesterone (17OHP) and 21-deoxycortisol (21DF). The LC-MS/MS-specific 17OHP thresholds are lower than those based on immunoassay and are suitable for NCCAH diagnosis. 21DF shows high sensitivity and specificity for the diagnosis of NCCAH and heterozygosity (HTZ).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Ditte Sofie Dahl Sorensen, Jesper Krogh, Ase Krogh Rasmussen, Mikkel Andreassen
Summary: The study demonstrated moderate to excellent repeatability in hormone levels among adult female patients with 21-hydroxylase deficiency, regardless of the time of day for blood sample collection. Additionally, only 21% of cases showed complete concordance in levels of 17-hydroxyprogesterone, androstenedione, and testosterone in a single-day measurement.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Ditte Sofie Dahl Sorensen, Jesper Krogh, Ase Krogh Rasmussen, Mikkel Andreassen
Summary: The study found that adrenal hormone levels in adult female patients with 21-hydroxylase deficiency showed moderate to excellent repeatability in everyday clinical practice, despite considerable variation in the time of blood sample collection. The repeatability of hormone levels was not affected by the use of long-acting glucocorticoids or the time of day for blood sample collection. No major predictors of hormone level variation were identified in the study.
ENDOCRINE CONNECTIONS
(2022)
Article
Endocrinology & Metabolism
Flavia A. Costa-Barbosa, Valdemir M. Carvalho, Kelly C. Oliveira, Jose Gilberto H. Vieira, Claudio E. Kater
Summary: Heterozygotes for 21-hydroxylase deficiency are common, and screening for asymptomatic carriers using LC-MS/MS-measured post-ACTH steroid phenotypes is valuable. New cutoff values for 21-deoxycortisol, 17-hydroxyprogesterone, and their ratio to cortisol were defined to distinguish different phenotypes, showing good sensitivity and specificity in identifying carriers of 21OHD.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mar Riveiro-Barciela, Cristina Marcos-Fosch, Fernando Martinez-Valle, Fabrizio Bronte, Olimpia Orozco, Isidro Sanz-Perez, Daniele Torres, Maria-Teresa Salcedo, Salvatore Petta, Rafael Esteban, Antonio Craxi, Maria Buti
Summary: Untreated HBeAg-negative CHB is an independent risk factor for carotid plaques and subclinical atherosclerosis, while ICs present a similar risk to controls.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Fredrik Sahlander, Sophie Bensing, Henrik Falhammar
Summary: This study investigated the prevalence of non-classic congenital adrenal hyperplasia (CAH) in a population with adrenal incidentalomas and reported their clinical characterization. The results showed a prevalence rate of 3.6% for non-classic CAH in this population, which should be confirmed by genetic analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
En Liu, Hengcong Luo, Kailv Zhou, Ying Zhang
Summary: This study retrospectively analyzed the clinical characteristics of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) and the relationship between gene mutations and endocrine hormones. The study also examined the relationship between different basal 17-hydroxyprogesterone (17OHP) levels and patients' glucolipid metabolism, hormone levels, pregnancy, and treatment outcomes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Hekma Saad Farghaly, Kotb Abbass Metwalley, Duaa Mohamed Raafat, Ghada Mohamed Saied, Magda Farghali Gabri, Magdy Algowhary
Summary: The study found that patients with CAH have endothelial dysfunction, significantly associated with NP levels, suggesting a crucial role of inflammation in the pathogenesis of vascular damage. Further research is needed to confirm these findings and explore the specific role of NP, whether protective or proatherothrombotic.
Article
Endocrinology & Metabolism
Kazuhiro Watanabe, Atsumi Tsuji-Hosokawa, Atsuko Hashimoto, Kaoru Konishi, Nobuyuki Ishige, Harumi Yajima, Akito Sutani, Hisae Nakatani, Maki Gau, Kei Takasawa, Toshihiro Tajima, Tomonobu Hasegawa, Tomohiro Morio, Kenichi Kashimada
Summary: This study utilized LC-MS/MS to screen for 21-hydroxylase deficiency (21OHD) and developed a new screening algorithm. The results demonstrated that 21DOF, (4AD + 17 alpha OHP)/F, and 11DOF/17 alpha OHP were more relevant markers for 21OHD screening compared to 17 alpha OHP.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jun-hao Zhang, Wei Li, Cheng-yue Wang, An-ni Zhang, Ben-zhong Jia, Ya-wei Li, Zhen-duo Shi, Kai-fa Tang, Cong-hui Han
Summary: The study aims to investigate the relationship between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED). Results showed that serum 25(OH)D levels were significantly decreased in ED patients compared to the healthy control group, while CIMT values were significantly increased in the moderate and severe ED groups compared to the control group. IIEF-5 score was positively correlated with serum 25(OH)D level and negatively correlated with CIMT value. After adjusting for confounding factors, there were significant associations between CIMT values, 25(OH)D levels, and IIEF-5 scores.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ge Meng, Jiping Yao, Jiaoyang Li, Yeqing Gu, Hongmei Wu, Qing Zhang, Li Liu, Xuena Wang, Juanjuan Zhang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Kaijun Niu
Summary: This study investigated the relationship between whole-grain consumption and carotid atherosclerosis in adult Chinese population. The results showed no significant association between whole-grain consumption and the risk of carotid atherosclerosis.
Review
Cardiac & Cardiovascular Systems
Maria M. Pereira, Juan Torrado, Claudio Sosa, Yanina Zocalo, Daniel Bia
Summary: Preeclampsia is a serious pregnancy complication with potential origins in maternal cardiovascular maladaptation rather than just placental dysfunction. While a majority of cases may be related to abnormal placentation, not all affected women fit the placental hypothesis. Recent research suggests that arterial biomechanics play a significant role in preeclampsia pathophysiology, impacting maternal heart function and fetal-placental circulation.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)