Article
Cell Biology
Haitao Yu, Yanchao Liu, Ting He, Yao Zhang, Jiahua He, Mengzhu Li, Bijun Jiang, Yang Gao, Chongyang Chen, Dan Ke, Jianjun Liu, Benrong He, Xifei Yang, Jian-Zhi Wang
Summary: The analysis of platelet proteomics in T2DM patients with MCI revealed that the increase of optineurin and rGSK-3 beta(T/S9) can efficiently discriminate MCI patients, showing promise for predicting cognitive decline in T2DM patients.
Article
Geriatrics & Gerontology
Stefan Schneider, Doerte U. Junghaenel, Erik Meijer, Arthur A. Stone, Bart Orriens, Haomiao Jin, Elizabeth M. Zelinski, Pey-Jiuan Lee, Raymond Hernandez, Arie Kapteyn
Summary: This study examined whether response times (RTs) in online questionnaires can differentiate between cognitively normal respondents and those with cognitive impairment, no dementia (CIND). By analyzing RT parameters from 37 surveys administered online over 6.5 years, it was found that all three RT parameters were significantly associated with CIND, and could predict CIND over periods of up to 6.5, 4.5, and 1.5 years.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Francesca Chiara Pignalosa, Antonella Desiderio, Paola Mirra, Cecilia Nigro, Giuseppe Perruolo, Luca Ulianich, Pietro Formisano, Francesco Beguinot, Claudia Miele, Raffaele Napoli, Francesca Fiory
Summary: Diabetes mellitus can lead to cognitive dysfunction, with alterations in the dopaminergic system playing a role. Research suggests that advanced glycation end products may be associated with cognitive impairment and changes in the dopaminergic system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Chang Li, Rongbing Jin, Kaijun Liu, Yang Li, Zhiwei Zuo, Haipeng Tong, Jingna Zhang, Junfeng Zhang, Yu Guo, Yuqi Lai, Jinju Sun, Jian Wang, Kunlin Xiong, Xiao Chen
Summary: The study revealed that T2DM-MCI patients exhibited significant reduction in white matter volume compared to T2DM-NC patients, mainly in regions such as the temporal lobe, frontal lobe, and limbic system. The white matter volume of the left posterior cingulate, precuneus, insula, and right rostral middle frontal gyrus showed high diagnostic value for detecting cognitive impairment in T2DM patients, serving as independent imaging biomarkers for early identification.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Nutrition & Dietetics
Shih-Wei Nien, I-Hsin Lin, Hsiu-Chuan Wu, Yi-Hsiu Chen, Suh-Ching Yang
Summary: This study investigated the dietary intake and patterns of MCI patients in Taiwan, and found that MCI patients had higher copper intake and lower intake of low-fat meat compared to the healthy group. The findings also suggested that a high MIND diet score was associated with a lower risk of MCI. Further research with larger populations is needed to confirm these findings.
Article
Neurosciences
Yifan Li, Mingrui Li, Yue Feng, Xiaomeng Ma, Xin Tan, Yuna Chen, Chunhong Qin, Haoming Huang, Yi Liang, Shijun Qiu
Summary: The study aimed to explore spontaneous brain activity alterations in T2DM subjects, revealing that PerAF and ALFF may have different sensitivities in detecting abnormal brain activity. PerAF values may provide additional information and indicate potential neuronal activity in T2DM subjects without MCI, shedding new light on neuroimaging mechanisms underlying early cognitive decline associated with diabetes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Arpita Chakraborty, Sumukha Hegde, Samir K. Praharaj, Krishnananda Prabhu, Chhaya Patole, Ashok K. Shetty, Shreemathi S. Mayya, Raviraj V. Acharya, H. Manjunath Hande, M. Mukhyaprana Prabhu, Dinesh Upadhya
Summary: The study identified the age-related prevalence of MCI in Indian T2DM patients and found a link between cognitive dysfunction in T2DM patients and serum lipid composition. Untargeted and targeted lipidomic analysis revealed decreased levels of certain lipids in the MCI group, while specific sphingolipids were increased.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Rehanguli Maimaitituerxun, Wenhang Chen, Jingsha Xiang, Yu Xie, Atipatsa C. Kaminga, Xin Yin Wu, Letao Chen, Jianzhou Yang, Aizhong Liu, Wenjie Dai
Summary: This study aimed to develop and validate a nomogram-based model for detecting mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus (T2DM). The prevalence of MCI in T2DM patients was found to be 34.1%, and factors such as age, marital status, income, duration of diabetes, diabetic retinopathy, anxiety, and depression were independently associated with MCI. The nomogram based on these factors achieved an optimal diagnosis of MCI and could serve as a clinical tool for detecting MCI in T2DM patients.
JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Haina Zhang, Lou Yu, Gai Yun
Summary: The study aimed to investigate the levels of serum Klotho in type 2 diabetes patients with and without moderate cognitive impairment (MCI) and its prediction of MCI in older patients. The results showed that diabetic patients with MCI had significantly lower serum Klotho levels. Serum Klotho levels were negatively correlated with age, BMI, HbA1c, creatinine, and CRP, and positively correlated with education and HDL-C. Patients with reduced serum Klotho levels, along with lower HDL-C, higher HbA1c, creatinine, and CRP levels, shorter formal education, and longer duration of T2DM, had an increased risk of developing MCI.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Cell Biology
Anja Baric, Marina Dobrivojevic Radmilovic
Summary: Stroke is a major cause of mortality and disability globally. Recent studies have shown evidence of diabetes involvement in producing a chronic neuroinflammatory state, affecting recovery of function and cognition after stroke.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Yue You, Zhizhen Liu, Yannan Chen, Ying Xu, Jiawei Qin, Shuai Guo, Jia Huang, Jing Tao
Summary: This study estimated the prevalence of Mild Cognitive Impairment (MCI) in Type 2 Diabetes Mellitus (T2DM) patients through systematic review and meta-analysis. The results showed a high prevalence of MCI in T2DM patients worldwide, especially in China and Asia. Female patients had a higher prevalence of MCI compared to male patients, and older patients had a lower prevalence compared to younger patients.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Zhenjie Teng, Jing Feng, Ronghui Liu, Yanhong Dong, Huifang Chen, Jing Xu, Xin Jiang, Rui Li, Peiyuan Lv
Summary: This study found that different imaging markers of cerebral small vessel disease (CSVD), particularly total CSVD burden, were associated with an increased risk of mild cognitive impairment (MCI) and decline in Montreal Cognitive Assessment (MoCA) scores in patients with type 2 diabetes mellitus (T2DM). These findings provide clues for future studies to explore early diagnostic imaging markers of cognitive impairment in relation to T2DM.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Hanan Ehtewish, Abdelilah Arredouani, Omar El-Agnaf
Summary: The underlying mechanisms linking type 2 diabetes to cognitive dysfunction are still unclear, but may include factors such as hyperglycemia, insulin resistance, and neuroinflammation. Risk factors for dementia in diabetes patients include aging, poor glycemic control, hypoglycemic and hyperglycemic episodes, depression, and vascular complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Changxing Liu, Xinyi Guo
Summary: Adjuvant therapy with Chinese herbal medicine can effectively improve clinical symptoms and cognitive function, lower blood glucose, improve blood lipids, and is safe for patients with diabetes mellitus combined with cognitive impairment.
Article
Neurosciences
See Ann Soo, Kok Pin Ng, Fennie Wong, Seyed Ehsan Saffari, Chathuri Yatawara, Zahinoor Ismail, Nagaendran Kandiah
Summary: The study revealed a significantly higher prevalence of MBI and MBI-C total scores among MCI individuals compared to CN individuals. Among MCI individuals, there was a correlation between diabetes mellitus (DM) and the presence and severity of MBI, suggesting DM may be a risk factor for MBI. These findings indicate that optimizing DM may be a potential therapeutic approach to improve clinical outcomes in MCI patients with MBI.
JOURNAL OF ALZHEIMERS DISEASE
(2021)